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Showing 1 to 20 of 69 for “"Aspergillus fumigatus"”.
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Gliotoxin Production in Aspergillus fumigatus
<p>Aspergillus fumigalus is a ubiquitous fungus that causes an infection called aspergillosis in immune-compromised surgery patients (Latge, 2001, 384; Bok et al. 2006). Aspergillosis cases have increased in the past decade due to the increasing number of patients undergoing immunosuppressive …
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Aspergillosis: interactions of Aspergillus fumigatus andHuman Airway Cells
Aspergillus fumigatus is a filamentous fungus that colonises the lungs of immunosuppressed patients and causes aspergillosis. Despite recent medical advances, infectious diseases caused by opportunistic pathogens such as A. fumigatus are still one of the main causes of morbidity and mortality among …
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Novel Inducers of Gliotoxin Production In Aspergillus Fumigatus
… Gliotoxin, which is produced by a variety of <em>Aspergillus</em> species, <em>Trichoderma</em> species, and <em>Penicillium</em> species, exhibits immunosuppressive properties and has therefore been the subject of research for many laboratories. There have been a few proteins shown to regulate …
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Targeting Proteins of Aspergillus fumigatus for Monoclonal Antibody Production
… diagnostic tool for the invasive fungus Aspergillus fumigatus. rPPIase, rEglC and rCatB were purified from bacterial cultures. rPPIase and rCatB were emulsified in TiterMax® Gold adjuvant (CytRx Corporation, Los Angeles, CA) and used to immunize BALB/c mice. The rPPIase emulsion elicited …
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New Challenges in Azole Resistance Selection in Aspergillus fumigatus
Contains fulltext : 327953.pdf (Publisher’s version ) (Closed access)
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A Global and Targeted Proteomic Investigation of Aspergillus fumigatus
Aspergillus fumigatus is an opportunistic pathogen that can cause invasive disease in immunocompromised individuals and, less frequently, in immunocompetent hosts. Proteomic investigation of A. fumigatus has the potential to enable global analysis of protein expression, identify potential targets …
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Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus
… 200,000 life- threatening infections each year. Aspergillus fumigatus is the most prevalent pathogen isolated from patients with invasive aspergillosis, accounting for more than 60% of all cases. Currently, the only antifungal agents available with consistent activity against A. fumigatus are the …
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Regulatory and self-protection implications of gliotoxin bisthiomethylation in Aspergillus fumigatus
… produced by the opportunistic fungal pathogen Aspergillus fumigatus. It contains an intact disulphide bridge, which mediates its toxic effects via redox cycling. Like many other ETPs, a bisthiomethylated form is also produced. In the case of gliotoxin, bis(methyl)gliotoxin is formed for unknown …
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The Redox and Systems Biology of Ergothioneine Biosynthesis in Aspergillus fumigatus
… properties. EGT was first identified in Aspergillus fumigatus, in work pertaining to gliotoxin biosynthesis. Compared to wild-type, EGT levels were elevated in the absence of GliK, a gliotoxin biosynthetic enzyme. The work presented in this thesis demonstrates that deletion of A. …
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Targeting the Rho1 GTPase signalling pathway in <i>Aspergillus fumigatus</i>
… individuals with compromised immune systems, <i>Aspergillus fumigatus</i> has emerged as one of the most common airborne fungal pathogens in recent decades. In immunosuppressed patients, inhalation of <i>A. fumigatus</i> spores can initiate life-threatening invasive aspergillosis (IA) with …
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Characterising the response to gliotoxin exposure in Aspergillus fumigatus ΔgliT and ΔgliZ
… metabolite produced by the filamentous fungus Aspergillus fumigatus. Previous work has implicated its potent anti-fungal properties and importance as a virulence factor in human infection. Availability of the A. fumigatus genome has allowed for the characterisation of the gliotoxin biosynthetic …
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Functional Genomic Analysis of Natural Product Biosynthesis and Secretion in Aspergillus fumigatus
Aspergillus fumigatus is an opportunistic pathogen which can cause severe disease in immunocompromised patients. A. fumigatus produces metabolites, through a non-ribosomal peptide synthesis mechanism, including iron-chelating molecules known as siderophores and other unusual compounds such as …
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Biochemical characterization of Aspergillus fumigatus SidA: a flavin-dependent N-hydroxylating enzyme
… siderophore produced by the pathogenic fungus Aspergillus fumigatus during infection. This siderophore includes N5-hydroxylated L-ornithine in the peptide backbone that serve as iron chelators. Af SidA is the L-ornithine N5-hydroxylase, which performs the first enzymatic step in the …
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An Analysis of the Response of Aspergillus fumigatus and Candida albicans to Caspofungin
The filamentous fungus Aspergillus fumigatus is capable of causing a range of diseases in immunocompromised patients and is responsible for up to 3% of all hospitalbased deaths in the EU. The yeast Candida albicans induces a range of diseases in immunocompromised patients. Caspofungin is a recently …
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Targeting final steps of sugar nucleotide biosynthetic pathway against <i>Aspergillus fumigatus</i>
Aspergillus fumigatus is a fungal pathogen that causes a disease called invasive aspergillosis in immunocompromised patients, with mortality rates of approximately 50%. The risk of A. fumigatus infection is rising due to the increasing use of immunosuppressants in medical treatments such as organ …
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Investigating MCE Chemical Library Drugs for Combinational Therapies for Clinical Aspergillus fumigatus isolates
Aspergillus fumigatus is a globally present pathogen capable of inflicting debilitating and life-threatening opportunistic infections in individuals, primarily those who are immunocompromised. Diagnosing A. fumigatus infections is often difficult, leading to a delay in treatment which can greatly …
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The role of adaptive mechanisms in the development of azole resistance in Aspergillus fumigatus
Contains fulltext : 293024.pdf (Publisher’s version ) (Open Access)
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"Sugar Coat" Genetic & chemical validation of <i>Aspergillus fumigatus</i> cell wall targets
Aspergillus fumigatus is a filamentous fungus and considered a feared opportunistic pathogen in highly immunosuppressed patients. The spectrum and burden of clinical disease due to A. fumigatus is becoming increasingly complicated. Therapeutic management is limited to three antifungal classes …
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Structural and Mutational Analyses of Aspergillus fumigatus SidA: A Flavin-Dependent N-hydroxylating Enzyme
SidA from Aspergillus fumigatus is an N-hydroxylating monooxygenase that catalyzes the committed step in siderophore biosynthesis. This gene is essential for virulence making it an excellent drug target. In order to design an inhibitor against SidA a greater understanding of the mechanism and …
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