Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Asparagine synthetase"”.
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Effect of nitrogen form and genetic variations of the Asparagine-cycling pathway on maize ear growth
… dry weight as well as the transport amino acids asparagine and glutamine. This nitrogen-induction experiment was duplicated, and root, shoot, and ear tissues were profiled via RNA-Seq to characterize responses to ammonia or nitrate at four or eight hours after nitrogen treatment. Results suggest …
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The Essential Role of the Non-Essential Amino Acid Asparagine in Lymphoid Malignancies
… and metabolism therapeutically. Currently, asparagine depletion via L-Asparaginase in acute lymphoblastic leukemia (ALL) remains the only clinically approved therapy to date. In the first project, we showed that ALL cells are auxotrophic for asparagine and rely on exogenous sources for this …
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Investigating the biosynthesis of fosfazinomycin
… of arginine are described in Chapter 4. FzmA, an asparagine synthetase homolog, is a prime candidate for effecting this transformation, and I used a number of in vitro enzymatic assays to test for the desired FzmA activity. Unfortunately, I was unable to reconstitute the formation of …
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Transcriptional Regulation of the Metabolic Response to Therapy in Leukemia
… as a critical regulator of the response to asparagine deprivation in acute lymphoblastic leukemia (ALL). We found that under asparagine depleted conditions ZBTB1 enables cellular proliferation by promoting the synthesis of asparagine from aspartate. Mechanistically, ZBTB1 binds directly to a …
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Discovery of novel regulators and genes in nitrogen utilization pathways in maize
… of both the synthesis and degradation of asparagine are associated with the different N remobilization phenotypes of IHP1 and ILP1. The effect of asparagine cycling alleles was confirmed using a series of near isogenic lines where variant alleles for these genes were introgressed into the …
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Molecular And Therapeutic Implications Of Notch1 Signaling In Pediatric T-Cell Acute Lymphoblastic Leukemia
… including MDR1, ABCC5, reduced folate carrier, asparagine synthetase, thiopurine methyltransferase, Bcl-2 and dihydrofolate reductase. Our results suggest (1) multiple factors should be considered with attempting to identify molecular-based prognostic factors for pediatric T-ALL and (2) that, …