Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Asibi"”.
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Investigating the role of non-structural genes in the genotype and phenotype of yellow fever vaccine strain 17D
… was successfully derived by serial passage of Asibi virus 176 times in chick and mouse embryo tissue. The resulting vaccine strain, 17D, gave rise to all substrains in use today. Strain 17D and the resulting substrains, 17DD and 17D-204, were found to differ from Asibi virus by 20 amino acid …
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Investigation of the interplay of yellow fever virus structural protein epitopes and genetic diversity
… from serial passage of the wild type (WT) strain Asibi in chicken tissue. The mechanism of attenuation of 17D is incompletely understood. This dissertation investigates the contribution of the envelope (E) protein in YFV attenuation through its role in genetic diversity, tissue tropism and …
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Contributions of Structural and Non-structural Genes to the Attenuation of the 17D Vaccine
… was derived by serial passage of wild-type Asibi strain 176 times in mouse and chicken tissues. Despite the derivation of 17D over 75 years ago, the mechanism of attenuation is still poorly understood. The genomes of wild-type Asibi virus and the 17D vaccine substrains 17D-204, 17D-213 and …
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Characterization of the molecular and biological determinants of viral dissemination from the mosquito midgut: Yellow feber virus in Aedes aegypti
… YFV strains: the wild-type, disseminating Asibi strain, and the attenuated, non-disseminating 17D vaccine strain. These viruses were characterized in vitro in Vero green monkey kidney cells and C6/36 Ae. albopictus mosquito cells and in vivo for virus production, infection and dissemination …
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Population Structure of Yellow Fever Virus: Influence of Viral Diversity on Vaccine Attenuation
… between the prototype West African YFV strain Asibi, and a commercial aliquot of the YFV 17D-204 vaccine. In silico methods revealed the vaccine to be of lower diversity than the parental strain, leading to subsequent hypotheses that the level of complexity in the vaccine populations would be …
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Isoniazid and acetylisoniazid urine concentrations as a maker of adherence to isoniazid preventative therapy in children
The World Health Organization recommends the use of isoniazid preventive therapy to reduce the incidence of tuberculosis disease in populations at risk for developing the disease. Adherence to isoniazid preventive therapy is needful for efficacy. A urine assay known as the Arkansas test is widely …