Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"Aryl hydrocarbon receptor"”.
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Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease
Activation of the aryl hydrocarbon (AhR), a ligand-activated transcription factor present in many immune cells, can trigger immunosuppressive responses through the generation of regulatory cells. Several AhR ligands exist in the diet including environmental contaminants, such as its prototypical …
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Consequences of Aryl hydrocarbon receptor activation in dendritic cells
… causes immunosuppression via activation of the Aryl hydrocarbon receptor (AhR). Dendritic cells (DCs), the professional antigen-presenting cells in the immune system, are adversely affected by TCDD. However, limited information exists regarding the effects of AhR activation on DCs. We evaluated …
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Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease
Activation of the aryl hydrocarbon (AhR), a ligand-activated transcription factor present in many immune cells, can trigger immunosuppressive responses through the generation of regulatory cells. Several AhR ligands exist in the diet including environmental contaminants, such as its prototypical …
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Consequences of Aryl hydrocarbon receptor activation in dendritic cells
… causes immunosuppression via activation of the Aryl hydrocarbon receptor (AhR). Dendritic cells (DCs), the professional antigen-presenting cells in the immune system, are adversely affected by TCDD. However, limited information exists regarding the effects of AhR activation on DCs. We evaluated …
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REGULATION OF CIRCADIAN CLOCKS AND METABOLISM BY ARYL HYDROCARBON RECEPTOR
The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, plays a crucial role in regulation of xenobiotic metabolism. AhR is also involved in dioxin-induced metabolic disorders and alteration of circadian rhythm. Furthermore, circadian clock disruption and metabolic dysfunction …
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The aryl hydrocarbon receptor signaling pathway and adverse reproductive outcomes
… work was to better understand the role of the aryl hydrocarbon receptor (AHR) signaling pathway and the circadian locomotor output cycles kaput (CLOCK) gene in experiencing adverse reproductive outcomes during the transition into reproductive senescence. Specifically, I examined the …
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Differential mechanisms by which the aryl hydrocarbon receptor attenuates liver regeneration
… hepatectomy (PH) can be attenuated by the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that is involved in hepatic organogenesis and cell cycle control. This growth suppression suggests that AhR modulates critical signaling processes of the regenerative program. …
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Characterization of Aryl Hydrocarbon receptor and Kruppel-Like-Factor-6 interaction
The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor which regulates toxic response to environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Upon ligand activation, the AhR translocates to the nucleus, dissociates from its chaperone complex, and …
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Mechanistic study of aryl hydrocarbon receptor nuclear translocator (ARNT)-mediated signaling
<p>A novel aryl hydrocarbon receptor nuclear translocator (ARNT)-interacting peptide (Ainpl) was characterized from human liver cDNA library using phage display. Ainpl suppresses hypoxia inducible factor-1a (HIF-1α) signaling pathway through an ARNTdependent manner. HIF-1α is known to be …
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Comparative analyses of aryl hydrocarbon receptor structure and function in marine mammals
… developmental defects in laboratory animals. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, mediating the expression of a suite of genes in response to exposure to DLC and structurally related chemicals. Species-specific differences in AHR structure can affect an …
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The Role of the Aryl Hydrocarbon Receptor in Tumor Growth and Chemoresistance
The aryl hydrocarbon receptor (AHR) has been shown to play a role in cancer initiation and progression in oral squamous cell carcinomas (OSCC), and other cancers. The AHR is activated by environmental toxins, including polycyclic aromatic hydrocarbons, which are commonly found in cigarette smoke. …
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Uncovering novel actions of numb and aryl hydrocarbon receptor in the pituitary
… well as both intrinsic and extrinsic effects of aryl hydrocarbon receptor activation, on pituitary hormone producing cells. The adaptor protein Numb was originally described as an important mediator of asymmetric cell division during neurogenesis, however in the study described here it is shown …
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Glucose and Lipid Dysregulation Following Loss of Hepatic Aryl Hydrocarbon Receptor in Mice.
The aryl hydrocarbon receptor (AhR) is a cytosolic, ligand activated transcription factor commonly known for its role in environmental toxicant metabolism. However, the generation of AhR knockout (AhR-KO) mice has shown physiological roles for the AhR in normal liver growth and development, insulin …
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Novel Roles of the Aryl Hydrocarbon Receptor in Normal Physiology and Epigenetic Reprogramming
The Aryl hydrocarbon Receptor (AhR) is a ubiquitously expressed, evolutionarily conserved, ligand activated, cytosolic transcription factor belonging to the basic Helix-loop-helix Per-ARNT-Sim superfamily of proteins. AhR has classically been associated with environmental toxicology owing to the …
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Analysis of the Role of bHLH/PAS Proteins in Aryl Hydrocarbon Receptor Signaling
The aryl hydrocarbon receptor (AHR) is a basic helix-loop-helix PER/ARNT/SIM (bHLH-PAS) transcription factor that binds ligands typified by 2,3,7,8-tetracholordibenzo-p-dioxin, translocates to the nucleus, dimerizes with the aryl hydrocarbon nuclear translocator (ARNT) and associates with specific …
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Study of the aryl hydrocarbon receptor as a target for rational drug design
<p>The aryl hydrocarbon receptor (AhR) heterodimerizes with the aryl hydrocarbon receptor nuclear translocator (Arnt) for transcriptional regulation. We generated three N-terminal deletion constructs of the human AhR of 12-24 KDa in size—namely D1 (aa 84-295), D2 (aa 84-192) and D3 (aa 191-295)—to …
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CONSEQUENCES OF ARYL HYDROCARBON RECEPTOR ACTIVATION IN STEADY-STATE AND INFLAMMATORY DENDRITIC CELLS
The aryl hydrocarbon receptor (AhR) is a steroid-like transcription factor that mediates the toxicity of various environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and TCDD-like compounds. Exposure to environmentally relevant levels of TCDD and TCDD congeners has been …
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CONSEQUENCES OF ARYL HYDROCARBON RECEPTOR ACTIVATION IN STEADY-STATE AND INFLAMMATORY DENDRITIC CELLS
The aryl hydrocarbon receptor (AhR) is a steroid-like transcription factor that mediates the toxicity of various environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and TCDD-like compounds. Exposure to environmentally relevant levels of TCDD and TCDD congeners has been …
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Comparative analyses of aryl hydrocarbon receptor structure, function, and evolution in marine mammals
… developmental defects in laboratory animals. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, mediating the expression of a suite of genes in response to exposure to DLC and structurally related chemicals. Species-specific differences in AHR structure can affect an …
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Mechanisms of action for aryl hydrocarbon receptor ligands in the PLHC-1 cell line
Aryl hydrocarbon receptor (AHR) expression and activity was characterized in the teleost hepatoma cell line, PLHC-1. This work was carried out in order to gain insights into mechanisms of halogenated aromatic hydrocarbon (HAH) toxicity. The results improve our ability to characterize the risks …
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