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Showing 1 to 15 of 15 for “"Aryl halide"”.
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Mechanistic studies on palladium-catalyzed C-N cross-coupling reaction
… several kinetic studies employing simple aryl halide and amine coupling partners were performed to elucidate unknown reaction pathways. Chapter 1. The resting state for the palladium catalyzed cross-coupling of various diarylamines and aryl halides is found to be the diphenylamido complex. …
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Novel reactions of a neutral organic reductant : reductive coupling and nanoparticle synthesis
… for nickel-catalyzed reductive coupling of aryl halides in order for the reaction to be homogeneous and avoid the traditional co-reductant, zinc, previously reported for these Yamamoto-type dehalogenative couplings. Reductive coupling was somewhat successful for specific substrates, …
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Expanding the substrate scope in palladium-catalyzed C-N and C-C bond-forming reactions
… study of the palladium-catalyzed amination of aryl nonaflates is reported. Use of bulky electron-rich monophosphinobiaryl ligands or BINAP allow for the catalytic amination of electron-rich and -neutral aryl nonaflates with both primary and secondary amines. Using XantPhos, the catalytic …
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New Methods in Aryne Chemistry
… products, organic materials, catalysts, and polyaryl compounds. They are neutral, reactive, aromatic intermediates lacking two adjacent hydrogen atoms on an aromatic ring. They offer the strategic advantage of rapidly functionalizing an aromatic ring by forming multiple carbon−carbon or …
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IMPROVING THE SCOPE AND UNDERSTANDING OF THE SYMMETRIC AND ASYMMETRIC SUZUKI COUPLING REACTION
… in which isolated pre-activated sodium trihydroxyarylborate salts were employed as the organoboron coupling partner, resulting in a more convenient and stoichiometrically efficient process. This alternative protocol has been applied to symmetric Suzuki reactions employing simple electron-rich and …
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Mechanistic studies on metal-catalyzed carbon-nitrogen bond forming reactions
… the mechanism of the copper-catalyzed N-arylation of amides using aryl iodides, i.e., the Goldberg reaction. The focus of the work has been directed towards amides since this reaction remains the most versatile in the presence of Cu(I)/1,2- cliamine catalyst systems. The results provide …
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Investigation of aryldimethylsilanolates in palladium-catalyzed cross-coupling reactions and development of chiral bis-hydrazone ligands for asymmetric aryl-aryl couplings
The preparation of biaryls by palladium-catalyzed cross-coupling of aromatic bromides and chlorides with alkali-metal salts (potassium and sodium) of aryl- and heteroarylsilanols has been developed. The critical feature for the success of this method is the use of …
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Late transition metal catalyzed C-N and C-C bond forming reactions
… methods for the palladium-catalyzed amination of aryl halides are described. Key to these is the development of new catalysts and reaction conditions for these transformations. Initially, P(o-tol)3 ligated palladium catalysts were investigated but gave way to systems that used chelating phosphine …
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A kinetic template effect in arylphosphonium salt formation.
… template effect" which assists the formation of arylphosphonium salts from aryl halides and tertiary phosphines in the presence of a transition metal halide catalyst in refluxing ethanol. The "kinetic template effect" arises from the presence in the aryl halide of a limited range of …
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Developing and Understanding Iridium-Catalysed Arene Borylation
… with the methodology. The one-pot conversion of aryl boronates, generated by C-H borylation, to other functionality has been one area of interest. However, reactions typically require a change in reaction solvent to make this possible. This thesis describes a one-pot, single solvent C-H …
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Greener Photoredox-Catalyzed Phosphonations of Aryl Halides
… have been used to access these motifs, aryl halides remain one of the most desirable coupling partners owing to their low cost, commercial availability, and regioselective reactivity. Traditional phosphonation often requires the use of harsh reductants in the presence of liquid ammonia, …
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I. Reaction mining—a next-generation platform for reaction discovery II. Rapid, anhydrous, homogenous Suzuki-Miyaura cross-coupling of aryl and alkylboronates
… data science, and (2) preparative methods for aryl-aryl and B-alkyl Suzuki-Miyaura cross-coupling of boronic esters and boronates. Chapter 1 describes previous efforts by Sarlah and Shved to accelerate the reaction discovery process with the combination of data science, HTE, and artificial …
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Synthetic Design of Multiphase Systems for Advanced Polymeric Materials
… copper mediated cross-coupling chemistries, the aryl halide functionalities were leveraged to decorate the polymer backbone with pendant perfluoroalkyl chains. The blocky perfluoro alkyl PEEK demonstrated preserved crystallizability and serves as a candidate for compatibilization of …
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Synthesis of Highly Ordered Polymer Nanostructures Based on Polyphenylene Vinylenes (PPVs)
… that converts three high-band gap poly(arylene ethynylene)s into low band gap donor-acceptor copolymers containing CPAAs. The methodology relies on a palladium-catalyzed cyclopentannulation between an aryl halide and the ethynylene groups in the polymer backbone. The new strategy …
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Mechanism and application of Lewis and Brønsted acid effects in organotransition metal catalysis
… mechanistic study implicates the role of halide anions in inhibiting this catalytic reaction, and it is proposed that metal triflates are competent to accelerate catalysis by binding halide anions, and therefore attenuating halide inhibition. This hypothesis is supported by initial rate …