Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 64 for “"Aryl Hydrocarbon Receptor (AhR)"”.
-
Novel Functions of the Transcription Factor Aryl Hydrocarbon Receptor (AHR) and Its Tryptophan-Derived Ligands in Cancer Cells
… focusing on the proto-oncogene MYC and the aryl hydrocarbon receptor (AHR). The role of MYC in regulating tryptophan (Trp) metabolism was investigated in colon and liver cancer cells using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). Our findings reveal that …
-
Exploring the role and the function of Aryl Hydrocarbon Receptor (AhR) and Aryl Hydrocarbon Nuclear Translocator (ARNT) in T cells
The Aryl Hydrocarbon Receptor (AhR) and the Aryl Hydrocarbon Nuclear Translocator (ARNT) play a role in mediating transcriptional responses to environmental pollutants, including the highly toxic compound 2,3,7,8-tetrachlorodibenzo -p-dioxin (TCDD) but also endogenous physiological ligands. More …
-
The effect of different sample preparatory protocols on the induction of the aryl hydrocarbon receptor (AhR) in the H4IIE–luc reporter gene bio–assay
… which could lead to super induction of the aryl hydrocarbon receptor (AhR) and therefore, to a positive bias in the results. Instrumental screening proved that all selected preparatory protocols were inadequate at removing interfering compounds and not sufficiently selective for PCDD/Fs, …
-
Analysis of the interaction between the co-chaperone p23 and the aryl hydrocarbon receptor
<p>The aryl hydrocarbon receptor (AhR) carboxyl terminal transcriptional activation domain was cloned, purified in denatured conditions from bacteria, refolded via limited dialysis, and analyzed for proper refolding via co-immunoprecipitation with the known binding partner SRC-1. This AhR NΔ515 …
-
Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer
… cytochrome P450 enzymes. BaP is a ligand for the aryl hydrocarbon receptor (AhR) which activates CYP1 gene transcription. Polymorphisms in these genes affect enzyme activity and therefore BaP bioactivation.
-
Comparative analyses of aryl hydrocarbon receptor structure, function, and evolution in marine mammals
… developmental defects in laboratory animals. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, mediating the expression of a suite of genes in response to exposure to DLC and structurally related chemicals. Species-specific differences in AHR structure can affect an …
-
Sledování vybraných markerů poškození tlustého střeva po indukci zánětu
… patří do idiopatických střevních zánětů. Aryl hydrocarbon receptor (AHR) je cytoplazmatický protein, u něhož se předpokládá jistá role v ovlivnění imunitního systému. Bilirubin je endogenní substance, u které jsou popisovány antioxidační a protizánětlivé účinky, které by mohly hrát roli v …
-
Mechanisms of action for aryl hydrocarbon receptor ligands in the PLHC-1 cell line
Aryl hydrocarbon receptor (AHR) expression and activity was characterized in the teleost hepatoma cell line, PLHC-1. This work was carried out in order to gain insights into mechanisms of halogenated aromatic hydrocarbon (HAH) toxicity. The results improve our ability to characterize the risks …
-
Investigation of ARNT isoform-specific regulation of AHR signaling
The aryl hydrocarbon receptor nuclear translocator (ARNT) is alternatively spliced into two distinct isoforms, isoform 1 and 3. Although ARNT is found to be critical in immunity, xenobiotic, and hypoxic response, ARNT isoform-specific function has yet to be investigated. We previously demonstrated …
-
Biomarkers of Human Exposure and Effect to Petrogenic Polycyclic Aromatic Hydrocarbons
… (DWH) oil spill. Petrogenic polycyclic aromatic hydrocarbons (PAHs) found in crude oil have the potential to bioaccumulate in seafood and render consumers vulnerable to adverse health effects. Despite the knowledge that alkylated PAHs abundant in petrogenic PAH mixtures can be potent activators …
-
Overexpression of Human Aryl Hydrocarbon Receptor in <i> E.coli</i> Using Two Different Solubility Enhancing Tags
… pollutants whose toxic effects are mediated via aryl hydrocarbon receptor (AhR) signaling pathway. AhR is a ligand sensitive transcription factor. The unbound AhR resides in cytoplasm as a complex containing p23, Hsp90 and XAP2. Upon ligand binding, AhR undergoes conformational change and …
-
Characterization of an aryl hydrocarbon receptor from a cetacean : an approach for assessing contaminant susceptibility in protected species
… concentrations of halogenated aromatic hydrocarbons (HAH) in their tissues, but little is known about the effects of such burdens on cetacean health. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related HAH cause toxicity via activation of the aryl hydrocarbon receptor (AHR), a member …
-
Characterization of Aryl Hydrocarbon receptor and Kruppel-Like-Factor-6 interaction
The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor which regulates toxic response to environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Upon ligand activation, the AhR translocates to the nucleus, dissociates from its chaperone complex, and …
-
Neutrophil Regulation of Colitis
… of IL-17 and IL-22. IL-23 signals through its receptors and further upregulates its own receptors. Subsequently, IL-23 activates the PI3K-mTOR pathway, which mediates the expression of retinoid acid receptor–related orphan receptor g t (RORγt) and aryl-hydrocarbon receptor (AhR). Neutrophils …
-
Differential mechanisms by which the aryl hydrocarbon receptor attenuates liver regeneration
… hepatectomy (PH) can be attenuated by the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that is involved in hepatic organogenesis and cell cycle control. This growth suppression suggests that AhR modulates critical signaling processes of the regenerative program. …
-
Glucose and Lipid Dysregulation Following Loss of Hepatic Aryl Hydrocarbon Receptor in Mice.
The aryl hydrocarbon receptor (AhR) is a cytosolic, ligand activated transcription factor commonly known for its role in environmental toxicant metabolism. However, the generation of AhR knockout (AhR-KO) mice has shown physiological roles for the AhR in normal liver growth and development, insulin …
-
Analysis of the aryl hydrocarbon receptor and a truncated form (AHR C[upper case symbol for greek Delta]Δ553) in cancer cells
<p>The aryl hydrocarbon receptor (AhR) is a ligand-activated bHLH-PAS protein that binds its partner, the aryl hydrocarbon receptor nuclear translocator (Arnt), in the nucleus to initiate the expression of proteins involved with detoxification. Published work suggests cross-talk between both …
-
Comparative analyses of aryl hydrocarbon receptor structure and function in marine mammals
… developmental defects in laboratory animals. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, mediating the expression of a suite of genes in response to exposure to DLC and structurally related chemicals. Species-specific differences in AHR structure can affect an …
-
Novel Insights Into Normal Aryl Hydrocarbon Receptor Biology Through the Regulation of Stanniocalcin 2
… is clinically important, and evidence that the Aryl hydrocarbon Receptor (AhR) can promote cell survival following intrinsic apoptotic stimuli is integral to the regenerative process. Recent evidence suggests that the AhR promotes cell survival through the PI3K-Akt/PKB axis in the absence of an …
-
Analysis of the Role of bHLH/PAS Proteins in Aryl Hydrocarbon Receptor Signaling
The aryl hydrocarbon receptor (AHR) is a basic helix-loop-helix PER/ARNT/SIM (bHLH-PAS) transcription factor that binds ligands typified by 2,3,7,8-tetracholordibenzo-p-dioxin, translocates to the nucleus, dimerizes with the aryl hydrocarbon nuclear translocator (ARNT) and associates with specific …
Page 1 of 4