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Showing 1 to 7 of 7 for “"Artificial Metalloenzyme"”.
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Development Towards an Ethylene Sensing Artificial Metalloenzyme
… it within a protein scaffold making it an artificial metalloenzyme. To this end biotinylated N-heterocyclic carbenes (NHCs) were synthesized, which can be appended onto the ruthenium probe. Efforts towards the expression and purification of the protein scaffold are also here reported.</p> …
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Design, engineering & characterization of a PQQ containing artificial metalloenzyme
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms
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Enantioselective epoxidation catalyzed by manganese-substituted human carbonic anhydrase
<p>Artificial metalloenzymes are an important class of hybrid catalysts for enantioselective, regioselective and chemoselective organic transformations. Despite several limitations associated with this type of hybrid catalysts system and their limited development relative to small molecule …
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Metalloprotein Engineering Using Heme Protein Scaffolds to Investigate the Oxidation of Endogenous Aromatic Amino Acids and Exogenous Substrates
… design has been used to study heme proteins and artificial Mn-salen containing metalloenzymes using heme protein scaffolds. Heme proteins perform a wide variety of functions including the catalysis of numerous different reactions. Some of the structural features involved in conferring these …
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Rational Design of Catalytic Metal Complexes for Potential Applications in Anticancer Chemotherapy
… be utilised in a novel fashion as small-molecule artificial metalloenzyme-like drug candidates. Specifically, we were interested in disrupting the strict redox homeostasis found inside the intracellular environment of cancer cells. The research described herein details the development process of …
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Mechanistic study and protein engineering of a dye-decolorizing peroxidase from Thermomonospora curvata for enhanced and expanded functions
… The enzyme scaffold not only accommodated the artificial metal center but also influenced diastereo- and enantioselectivity, which was further improved through mutagenesis. These findings establish TcDyP as a promising platform for artificial metalloenzyme development. In the final chapter, …
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Pushing the limits of aldoxime dehydratases for the synthesis of industrial relevant nitriles and their use in chemo- and biocatalytic cascade reactions
… The first approach was the creation of an artificial hydroformylase based on the reconstitution of a P450 monooxygenase, namely CYP119, with a Rhodium-porphyrin ligand (Rh-PO) which showed hydroformylation activity for the hydroformylation of 1-octene. After expression in minimal medium and …