Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Artesunate"”.
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Artesunate and amodiaquine : tolerability and drug interaction study in healthy normal volunteers
Includes bibliographical references.
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Evaluation of Dose-Exposure-Response Relationships of Miltefosine and Discovery of Multicomponent Crystal Forms of Artesunate
… (i.e., children v adults) in clinical trials. Artesunate (ATS), a BCS class II drug widely used for anti-malaria therapy, exhibits not only poor solubility but also poor stability in aqueous solution. Aim: This study aimed to characterise the solid-state properties of miltefosine, attempt to …
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The efficacy and safety of artesunate suppositories in combination with other antimalarials in the treatment of severe malaria in Sudan.
… is a limited documentation on the efficacy of artesunate in Africa with no experience in Sudan. Severe malaria in Sudan is common in its rural areas where lack of facilities for the safe and effective parenteral use of quinine causes long delays before the patient can reach a suitable centre …
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A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga
… the treatment of first line malaria, including artesunate monotherapy, artesunate combinations, pyronaridine, atovaquone-proguanil, co-artemether, halofantrine, amodiaquine, and mefloquine. It was found that sulfadoxinepyrimethamine was 5 times more cost-effective as first line therapy than …
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Efficacy of sulfadoxine-pyrimethamine with and without artesunate for the treatment of uncomplicated malaria in Mozambique : a randomised controlled trial
… for uncomplicated falciparum malaria; the use of artesunate (AS) in combination with sulfadoxine-pyrimethamine (SP) is recommended by the World Health Organisation (WHO). Mozambique policy-makers recommended that an ACT be implemented and studied in 2003. Therefore this RCT was conducted to …
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An investigation into the molecular mechanisms induced by derivatives of natural products in oesophageal cancer
… of two first generation artemisinin derivatives (artesunate and dihydroartemisinin), together with novel artemisinin hybrid compounds, as cancer chemotherapeutic agents and explored the mechanism of action in oesophageal cancer. Artesunate and dihydroartemisinin including seventeen other …
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A study of the immune response in murine experimental malaria, with special reference to the effects of South African medicinal plants, artesunate and chloroquine
… for C57BL/6 and A/J mice. A 14-day course of artesunate 100 mg/kg prevented completely the development of parasitaemia and cerebral malaria in Plasmodium berghei ANKA infected mice, with survival of more than 60d. Chloroquine enhanced production of IL-10. Artesunate displayed enhanced IL-1 0 …
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Anti-malaria drug treatment in Vietnam
… Antimalarial treatment with artemisinin, artesunate, or artemether has proved rapidly effective in the treatment of non complicated and complicated malaria and remarkably nontoxic. However there is a number of important questions that still need urgent attention: Should artemisinin be …
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Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated Falciparum malaria
… study of the fixed-dose combination therapy, artesunate-amodiaquine. RESULTS: The day 28 genotype-adjusted adequate clinical and parasitological response rate of artesunate-amodiaquine combination in 321 patients studied was above 97% in both the intention-to-treat and per protocol analyses in …
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Pharmacometrics of dolutegravir and tenofovir: a quantitative approach to characterise drug-drug interactions, pharmacogenetics and optimise treatment
… antimalarial drugs artemether-lumefantrine and artesunate-amodiaquine. We also describe the pharmacokinetics of tenofovir when dosed as either tenofovir disoproxil fumarate or tenofovir alafenamide in South Africans living with HIV. We found that rifampicin increases dolutegravir clearance more …
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Evaluating the cost-effectiveness of artemisinin-based combination antimalarial drugs and malaria rapid diagnostic tests within the context of effective vector control : case study of Southern Africa
… and treating malaria patients with an ACT (using artesunate + SP) were implemented at pilot level in 2003.
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Effect of dihydroartemisin-piperaquine for malaria intermittent preventive treatment on dolutegravir exposure in pregnant women living with HIV
… pregnancy. However, another antimalarial drug, artesunate-amodiaquine, similar to dihydroartemisininpiperaquine, was previously shown to reduce dolutegravir exposure in non-pregnant adults. Objective: To investigate the effect of dihydroartemisinin-piperaquine for IPTp on dolutegravir plasma …
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Analysis of within-host evolution of Plasmodium Falciparum during treatment
… but SNPs at codon D547E showed association with Artesunate and D559E with AQ and MQ IC50 respectively. Even though there is an exponential increase in the number of non-synonymous point mutations in the Pfk13 gene, the Kenyan P. falciparum strains remain sensitive to ACT drugs. Further research …
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Joint models for nonlinear longitudinal profiles in the presence of informative censoring
… (SP) and a combination of artesunate and sulfadoxine-pyrimethamine (ACT), in eliminating asexual parasites in patients. The patients enrolled in the study had uncomplicated malaria, at a time of increasing resistance to sulfadoxine-pyrimethamine (SP) treatment. Blood samples …
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Estimating antimalarial drug activity in vivo: an interdisciplinary approach combing novel experimental data with mathematical modelling
Malaria infections led to an estimated 627 000 deaths in 2020. Artemisinin-based combination therapies are the current first-line malaria treatments. However, it is urgent to develop better antimalarial because artemisinin-resistant parasites are spreading, and the international efforts to …