Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Arterial Spin Labeling"”.
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Efficiency of background suppression for arterial spin labeling
Arterial spin labeling (ASL), a technique developed for the measurement of local tissue perfusion with MRI, is heavily dependent on distinguishing irrelevant static tissue signal from the labeled blood. Background suppression can greatly reduce motion and other sources of noise in Arterial Spin …
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DEVELOPMENT OF IMPROVED ARTERIAL SPIN LABELING METHODS IN HUMANS AND ANIMAL MODELS
Arterial spin labeling (ASL) is an important tool in evaluating cerebral blood flow (CBF), with applications in clinical imaging for brain tumors and stroke, and as a research tool for brain injury and Alzheimers disease. Multi-TI ASL makes it possible to measure CBF and arterial transit time …
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Measurement of Cerebral Blood Flow Using Arterial Spin Labeling Magnetic Resonance Imaging
… diseases non-invasively. Pseudo-Continuous Arterial Spin Labeling (pCASL) MRI is a new MRI technique that is able to detect blood flow changes, non-invasively. The blood flow change detected by pCASL MRI is relative and it is expressed in terms of arbitrary MRI units which does not have any …
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Improving the Robustness of Perfusion Imaging with Arterial Spin Labeling Magnetic Resonance Imaging
… the blood supply to the tissue through the arterial system and removes the metabolic by-products via the veins. Abnormalities and disruptions in this process can have profound effects. Cerebral blood flow (CBF), a quantitative perfusion measurement in the brain in units of milliliters of …
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Quantifizierung der Perfusion mit Arterial Spin-Labeling Techniken in der Magnetresonanz-Tomographie an Hand eines Perfusionsphantoms
Die Arterial Spin-Labeling Technik ermöglicht eine nicht-invasive Perfusionsbestimmung ohne Kontrastmittelgabe mittels Magnetresonanz-Tomographie. Im Rahmen dieser Arbeit wurde erstmalig ein MR-kompatibles künstliches Perfusionsphantom entwickelt und erprobt, mit dem ein Perfusions-Goldstandard in …
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Accuracy of pulsed arterial spin labeling magnetic resonance imaging in the human brain : tag width and timing effects
Arterial spin labeling (ASL) is the only non-invasive magnetic resonance imaging (MRI) technique that allows absolute quantification of cerebral blood flow (CBF). It involves using radiofrequency pulses designed to invert the spins of water in arterial blood, effectively creating a magnetic bolus. …
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Cerebral Blood Flow, Fitness and Behaviour Changes With a High Intensity, Socially Engaging Physical Activity Program for Young Adults With Autism Spectrum Disorder
… 3 x weekly unsupervised, MVPA intervention. Arterial spin labeling (ASL), fitness testing, and diagnostic measurements gauged changes in CBF, fitness, and behaviors respectively. Statistical significance (p<0.05) was found in the Autism Diagnostic Observation Schedule (ADOS II) (pre …
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Phase-based regional oxygen metabolism in magnetic resonance imaging at high field
… approach used standard gradient-echo (GRE) and arterial spin labeling (ASL) to make these measurements. Results for in vivo Y, and CMRO₂ estimates on human subjects are presented from application of our technique at 3 Tesla (3T). We also extended our method to high-field human imaging at 7 Tesla …
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Quantification of Myocardial Perfusion Based on Signal Intensity of Flow Sensitized MRI
… approach of measuring cardiac perfusion by arterial spin labeling, the relative difference in the apparent T1 relaxation times in response to selective and non-selective inversion of blood entering the region of interest is related to perfusion via a two-compartment tissue model. But …
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Pseudo Random Arterial Modulation (PRAM): A Novel ASL Approach to Measure Flow and Blood Transit Times
The Pseudo Random Arterial Modulation (PRAM) is a non-invasive MRI based method to measure blood flow. It does not require any contrast agent but rather uses water protons in the body as the contrast. PRAM is based on a pseudo random sequence of inversions and non-inversions of the arterial blood …
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Machine Learning Classification of Traumatic Brain Injury Patients Versus Healthy Controls Using Arterial Spin Labeled Perfusion MRI
… advanced neuroimaging techniques such as arterial spin labeling (ASL) can noninvasively assess cerebral blood flow (CBF) changes observed post-injury, this technique is underutilized in TBI research partly due to the low signal-to-noise-ratio (SNR) inherent in ASL imaging. The aim of the …
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Optimization of the Fair Technique for Specific Brain Region Perfusion Studies
… technical development and applications of ASL (arterial spin labeling) imaging have mainly focused on the superior cortical regions of the brain. However, optimal ASL measurements to quantify cerebral blood flow (CBF) in specific brain regions may require optimized parameters, improved …
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Predicting learning success from patterns of pre-training magnetic resonance images
… as well as diffusion tensor imaging (DTI) and arterial spin labeling (ASL). We then discovered that (patterns of) nonheme iron (not heme) is the underlying factor driving learning prediction. This discovery of the relationship between iron concentrations and learning ability in healthy young …
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Normalization of Cerebral Blood Flow, Neurochemicals, and White Matter Integrity After Kidney Transplantation
… We measured the effects of KT on CBF assessed by arterial spin labeling, cerebral neurochemical concentrations (N-acetylaspartate, choline, glutamate and glutamine, myo-inositol and total creatine) measured by magnetic resonance spectroscopic imaging, and white matter integrity measured by …
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Vertex-Based Analysis of Cerebral Blood Flow and Fractional Amplitude of Low-Frequency Fluctuations (CBF-fALFF) Coupling in Moderate-to-Severe Traumatic Brain Injury During the First Year Post-Injury
… a proxy for spontaneous neural activity. Using arterial spin labeling (ASL) and functional MRI sequences, CBF and fALFF were measured in 29 msTBI patients 3-, 6- and 12-months post-injury for within-group longitudinal comparisons. Thirty-four demographically matched healthy controls were …
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Multiparametric Estimation of Brain Hemodynamics with MR Fingerprinting ASL
… application in cerebrovascular diseases. Arterial Spin Labeling (ASL) MRI technique is capable of estimating cerebral blood flow (CBF) without radioactive tracer or contrast agent. However, the signal from ASL is affected by multiple parameters in the kinetic model, causing the complexity …
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Assessment of Brain Perfusion and Vascular Compliance with Magnetic Resonance Imaging
… imaging. I first developed a cardiac-triggered Arterial-Spin-Labeling (ASL) technique to enhance the sensitivity of brain perfusion MRI without using exogenous contrast agent. I demonstrated its utility in several experimental settings, including single-shot acquisition, multi-shot acquisition, …
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Measurement of Fluid Movement Throughout the Brain via Multiple Magnetic Resonance Imaging Techniques During High-Definition Transcranial Direct Current Stimulation
… to use Diffusion Tensor Imaging (DTI) and pulsed-Arterial Spin Labeling (pASL) to target interstitial fluid diffusion within the brain parenchyma as well as blood perfusion of brain tissue, respectively, with and without intervention of bi-frontal 4mA anodal tDCS. The MRI sequence cascade …
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Using Multimodal MRI Techniques to Understand the Role of Hippocampus in Schizophrenia
… hippocampal subregions in SZ. Pseudo-continuous arterial spin labeling (pCASL) was used to measure whole brain CBF at standard resolution, and we found hippocampal CBF had positive correlation with PANSS total scores. In the acquired equivalence (AE) fMRI study, reduced midbrain and hippocampal …
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Understanding the role of cerebrovascular health in cognitive aging: a multi-modal noninvasive human neuroimaging approach
… in a group of older adults (ages 55-85). Using arterial spin labeling (ASL) to quantify CBF, we found that blood flow in the gray matter was positively correlated with CRF and negatively correlated with age (Zimmerman et al., 2014). Subsequent analyses revealed that CRF fully mediated the …
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