Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Artemisinin Combination Therapies"”.
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An investigation of the mechanisms of piperaquine resistance in Plasmodium falciparum malaria
… available, with the most recent emergence to artemisinin combination therapies (ACTs). ACTs are the recommended front-line treatments for Plasmodium falciparum malaria worldwide and decreased susceptibility of parasites to both artemisinin and one of the widely used partner drugs, piperaquine, …
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Exploring Kinases of Metabolism and Signaling in the Malaria Parasite Plasmodium
… malaria, including the front-line treatments artemisinin and artemisinin combination therapies. Due to the rapidly increasing drug resistance problem, new multi-stage inhibitors of Plasmodium are desirable. Of particular interest as multi-stage drug targets are parasite kinases since they are …
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The influence of genetic background on drug resistance in the malaria parasite Plasmodium falciparum
… popular partner drugs in first-line artemisinin combination therapies. During my PhD, I assessed a panel of parasite lines that had undergone *in vitro* evolution experiments, identifying polymorphisms in a poorly characterised ABC transporter, ABCI3, that confer resistance to several …
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Antimalarial Drug Resistance: Mechanisms of Emergence in Low-Transmission Settings
… America and Colombia. In 2006, Colombia adopted Artemisinin Combination Therapies (ACTs) as front-line antimalarial treatments, and withdrew the previous frontline therapy, sulfadoxine-pyrimethamine. While sulfadoxine-pyrimethamine resistance is widespread, no resistance to ACTs has been detected …
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Investigation of azithromycin analogues and proteasome-like inhibitors as quick-killing antimalarials
… global implementation of vector control and artemisinin combination therapies have resulted in significant reductions in the global burden of malaria. Of current concern is the spread of multi-drug resistant parasites that have severely limited the efficacy of antimalarials, including …
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The occurence, distribution and frequency of membrane transporter resistance alleles in <i>Plasmodium falciparum</i> and their association with response and resistance to Arteminisin based combination therapy (ART) in Northern Nigeria
… related group of drug treatment, known as Artemisinin combination therapies (ACTs), primarily in parts of South East Asia, but possibly also in other parts of the world e.g. East Africa.<br/>The purpose of this research was to; analyse the occurrence and distribution frequency of membrane …
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Synthesis, structure-activity relationship and solubility improvement studies of potential antimalarial and antischistosomal pyrido[1,2-a]benzimidazoles
… antimalarial drugs in clinical use, the artemisinin combination therapies (ACTs) are faced with the challenges of limited availability, unaffordable cost, and undesirable adverse effects. On the other hand, the treatment of schistosomiasis is severely limited to one treatment regimen, …
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Piperazine-based pyrido[1,2-a]benzimidazoles: synthesis and pharmacological evaluation as potential antimalarial and antischistosomal agents
… to first-line antimalarial drugs comprising artemisinin combination therapies (ACTs) threaten malaria control. There is therefore a need to develop novel and chemically diverse alternatives that are safe, efficacious, and able to circumvent drug resistance. Schistosomiasis is the second most …
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Physicochemical, biological and β-haematin inhibiting activity of pyrido-dibemequines, pyrido[1,2-α]benzimidazoles and their derivatives
… with reduced sensitivity to the currently used artemisinin combination therapies. Classical aminoquinoline-based drugs inhibit the formation of haemozoin (HZ) thereby causing parasite death from the cellular accumulation of toxic 'free' haem. Coincidentally, this immutable pathway also exists in …
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Large–scale data–driven network analysis of human–plasmodium falciparum interactome: extracting essential targets and processes for malaria drug discovery
… Africa is traced mainly to Southeast Asia where artemisinin resistance rate is increasing. Although careful surveillance to monitor the emergence and spread of artemisinin-resistant parasite strains in Africa is on-going, research into new drugs, particularly, for African populations, is critical …
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Lead optimisation of dehydroemetine as an antimalarial option through drug repositioning and molecular modelling
… started to emerge for the currently recommended artemisinin combination therapies used to treat malaria. There is a great need for new anti-malarial drugs, but traditional drug discovery timelines take approximately 10-17 years. Drug repositioning offers a very effective alternative to de novo …
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Antimalarial imidazopyridazines and aminopyrazines: synthesis, physicochemical optimization and structure-activity relationships
… currently recommended first line treatment, the artemisinin combination therapies (ACTs), resistance to artemisinin and the partner drugs is beginning to emerge in South East Asia. Furthermore, the current portfolio of medicines, both in clinical use and development has several other shortfalls …
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Antimalarial benzimidazoles and related structures incorporating an intramolecular hydrogen bonding motif: medicinal chemistry and mechanistic studies
… with the WHO presently recommending the use of artemisinin combination therapies (ACTs) to treat uncomplicated malaria. However, there is compelling evidence from Southeast Asia and recently in Rwanda (Africa) describing the emergence and spread of ACT resistance, characterized by reduced …