Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Aromatic Residue"”.
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Biosynthetic and bioinformatic investigation of RiPPs with radical SAM-installed crosslinks
… enzymatic tolerance of DarE towards the modified residues of DarA and produced 51 modified variants, 10 with a bicyclic structure. We determined that DarE is under substrate control as an aromatic residue in position 3 of a crosslinking motif will dictate ether formation, while a non-aromatic …
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Genetic Variants in the Putidaredoxin-Cytochrome P-450(cam) Electron Transfer Complex: Identification of the Residue Responsible for Redox-State Dependent Complex Stabilization
… with native C-terminal tryptophan or aromatic substituted putidaredoxins are at least ten-fold higher than the average rates for reconstitutions with non-aromatic substituted proteins. The reduction of the oxy-cytochrome P-450$\sb{\rm cam}$ by Pd is the rate limiting step in the …
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Defining the functional response of Mycobacterium sp. infected macrophages to structural variants of Interferon gamma (IFN-y)
… in emission maxima, consistent with changes in aromatic residue environments and perturbations in tertiary structure. Collectively, these findings demonstrate that truncation near the C-terminal region is associated with measurable and consistent alterations in IFN-γ structural integrity. …
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Design and synthesis and testing of conformationally constrained peptidomimetics.
… hydrogen bond between the i and i+3 residues. Chapter Three introduces cysteine protease calpain II as the primary biological target for this thesis. Calpain is implicated in cataract formation and its inhibition is a logical approach to cataract prevention. Proteases are known to, …
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Leveraging Bio-Inspired Molecules for Cancer Theranostics
… found that iodination increased the degree of aromatic residue-driven aggregation of the peptides. We determined that these iodination-related trends stem from improved overall intramolecular order through H- and halogen bonding, in addition to intermolecular organization of the self-assembled …