Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Aromatase Inhibitor"”.
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Predicting Adherence to Aromatase Inhibitor Therapy in Patients with Breast Cancer Using Protection Motivation Theory
… the psychosocial factors affecting adherence to Aromatase Inhibitors (AI). The aim of this study is to identify and assess the factors affecting adherence to Aromatase Inhibitor Theory in breast cancer patients using the Protection Motivation.Methods: Cross-sectional retrospective study. 288 …
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Changes of breast cancer growth and metastasis in murine models modulated by an aromatase inhibitor, a low calcium diet or a high fat diet
… the hypothesis of this study is that the aromatase inhibitor letrozole may inhibit BC metastases to lungs by suppressing estrogen synthesis. BC growth on the bone micro-metastatic site and lung metastases were monitored in live animals via Bioluminescence Imaging (BLI). Effects of …
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Liquid chromatography-mass spectrometry, an evolution in doping analysis
… androst-4-ene-3,617-trione which can act as an aromatase-inhibitor. Finally, the application of LC-MS for the urinary detection of stimulants was investigated.
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Effects of benzo[a]pyrene and CYP19a1b knockdown on zebrafish development
… is both an endocrine disruptor and a carcinogen. Aromatase (CYP19) is a key enzyme in steroidogenesis playing a key role in the hypothalamus-pituitary-gonad feedback loop. We hypothesized that BaP would negatively impact cyp19a1b expression in zebrafish, in turn, adversely affecting development …
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Factors influencing in vitro maturation of pig oocytes
… of either an antiestrogen (tamoxifen) or an aromatase inhibitor (4-OHA). Before use, the content of estradiol receptors (ER) in CC and oocytes were determined by a binding assay, before, during and after maturation. The highest levels of ER were observed at 24 and 36 hours of maturation on …
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Testosterone’s regulation of the HPA axis differs for adolescent and adult male rats
… hormone (CRH), and a trend toward lower aromatase-immunoreactive cell counts in the parvocellular paraventricular nucleus (PVN) than did CTL rats, irrespective of age, and there were no group differences in the magnocellular PVN. In Experiment 3, gonadally-intact P45 and P75 males were …
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Hormonal factors and insulin-like growth factor-1 in North American postmenopausal women
… IGF-1 levels, and 2) to examine the effect of an aromatase inhibitor (AI) on IGF-1 levels, and the potential interaction with BMI. Methods: A cross sectional study and a randomized controlled trial nested with the MAP.3 chemoprevention trial were used to address objective 1 and 2, respectively. …
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Interaction of ACTH and Estradiol in the Regulation of Growth, Differentiation, and Steroidogenic Maturation of the Baboon Fetal Adrenal Gland
… role of ACTH on fetal adrenal development, the aromatase inhibitor CGS 20267 was administered to baboon mothers between days 100 and 164 of gestation (n = 3). CGS treatment suppressed maternal and fetal peripheral serum estradiol to less than 2% of control levels, and enhanced (P< 0.05) fetal …
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Mathematical Modeling of Therapies for MCF7 Breast Cancer Cells
… deprivation, which mimics the effects of an aromatase inhibitor, or fulvestrant, an ER degrader. These data were used to calibrate a mathematical model based on key interactions between ER signaling and the cell cycle. We show that the calibrated model is capable of predicting the combination …
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The decision making process in women diagnosed with estrogen receptor-positive breast cancer experiencing side effects related to oral endocrine therapy
Oral endocrine therapy (OET) is standard therapy for millions of estrogen receptor-positive breast cancer survivors (ER+BCS). OET reduces recurrence, mortality, and metastasis. ER+BCS often do not take their OET as recommended due to adverse side effects. The purpose of this dissertation was to …
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Integration of class 1 HDAC inhibitors into current treatments for prostate cancer
… prostate cancer (CRPC). Androgen signalling inhibitors (ASI), including Enzalutamide (ENZ) and Abiraterone (ABI), are effective treatments for metastatic CRPC however, resistance develops within 24-months of initial exposure in the majority of patients. <br/><br/>Epigenetic silencing of …
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The role of ERα in the uterus during embryo implantation and in the ovary during ovarian tumorigenesis
… that by treating animals with letrozole, an aromatase inhibitor, that ovarian tumor volume is decreased compared to untreated animals, indicating a novel role of ERalpha in ovarian tumorigenesis. This animal model mimics the genetic profile of human serous epithelial ovarian carcinoma and …
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Central Expression of Sex Steroid Receptors during the Ring Dove (Streptopeliarisoria) Breeding Cycle
… between steroid receptor expression and aromatase P450 enzyme(P450AROM)activity in the brain of the ring dove was also investigated. Sexually experienced ring doves were injected intramuscularly with the aromatase inhibitor fadrozole (0.2 ml of 1 mg n-A-') and paired with saline injected …