Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"Aromatase"”.
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Tamoxifen metabolites can target both aromatase and estrogen receptors
… estrogen receptor down-regulators (SERDs) and aromatase inhibitors (AIs). However, the efficacy and safety of SERMs, SERDs and AIs are compromised by side effects or tumor resistance. One possible way of improving treatment efficacy and safety profiles is to develop agents with dual aromatase …
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Spectroscopic characterization of iron-oxygen intermediates in human aromatase (CYP19A1)
CYP19A1 or aromatase, is a human steroidogenic P450 important for estrogen biosynthesis in humans. Over activation of aromatase results in malignancies of the breast tissue, especially in post menopausal women. In fact, aromatase inhibitors constitute the front line therapy for estrogen receptor …
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Cytoplasmic Cyclin E Mediates Resistance to Aromatase Inhibitors In Breast Cancer
… hormone receptors and need hormonal therapy. Aromatase inhibitors (AIs) block estrogen biosynthesis and are considered as the first line hormonal therapy for ER<sup>+ </sup>post-menopausal patients. However, resistance to these drugs remains a major challenge in clinic and the biology of such …
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Association of aromatase (TTTA)n repeat polymorphisms with central precocious puberty in girls.
… cytochrome P450 19A1 (CYP19A1) gene encodes an aromatase that is responsible for the conversion of androgens to estrogen, which is key step in estrogen biosynthesis. The aim of this study is to identify CYP19A1 gene mutations or polymorphisms in girls with central precocious puberty (CPP). …
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Cytochrome P450 1A1 and aromatase (CYP19) in cetaceans : enzyme expression and relationship to contaminant exposure
… of cetaceans to contaminant exposures. Aromatase is the enzyme responsible for estrogen production and recent studies suggest that PCBs may alter its activity or expression. We determined the sequence and characterized the catalytic properties of a cetacean aromatase, which was similar …
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Predicting Adherence to Aromatase Inhibitor Therapy in Patients with Breast Cancer Using Protection Motivation Theory
… the psychosocial factors affecting adherence to Aromatase Inhibitors (AI). The aim of this study is to identify and assess the factors affecting adherence to Aromatase Inhibitor Theory in breast cancer patients using the Protection Motivation.Methods: Cross-sectional retrospective study. 288 …
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Tracing Androgen Metabolism With Inhibition Of Aromatase In Breast Cancer: In Vitro Studies And Clinical Correlates
… of specific inhibitors targeting the enzyme aromatase represents a highly successful example of rational drug design in hormone-responsive cancer. Aromatase inhibitors (AI) are approved as a first line of therapy in both primary and metastatic estrogen-receptor positive (ER+) breast cancer, …
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Localization of P450 aromatase in sperm and estrogen receptors in the epididymal region of the rooster
… cells and epididymal sperm contain active P450 aromatase (P450arom) which converts androgens to estrogens; (2) ER and ER mRNA are present in the epididymal region of the rooster, which suggests that this region is a target for estrogen; and (3) steady state levels of ER mRNA in the epididymal …
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Symptoms Experienced By Post-Menopausal Breast Cancer Survivors On Aromatase Inhibitors: A Secondary Analysis Of Baseline Data
… Endocrine therapy for breast cancer with Aromatase Inhibitors (AI) is designed to reduce risk of recurrence and improve survival. AI therapy is associated with a variety of symptoms including musculoskeletal complaints, which have contributed to discontinuation of treatment. It is …
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P450 aromatase expression in germ cells and sperm of the adult mouse and rat testis and epididymis
… to be capable of synthesizing active P450 aromatase (P450arom), the estrogen synthesizing enzyme. This investigation was undertaken to establish that testicular germ cells and epididymal sperm contain active P450arom, to determine if P450arom mRNA is synthesized in germ cells, and to …
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Gonadotropin-Releasing Hormone Agonist Treatments Normalize Aromatase and Reduce Cyclooxygenase-2 in Ovarian Endometrioma and Eutopic Endometrium with Endometrosis
… whether GnRH agonists could normalize aromatase cytochrome P450 and cyclooxygenase-2 metabolism by direct action in the eutopic endometrium of endometriosis and ovarian endometrioma. METHODS: Endometrial specimens and ovarian endometrioma tissues were obtained from infertility women …
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Development Of Novel Analytical Methods For Detection And Determination Of Tamoxifen In Oral Fluid And Discrimination Between Regioisomeric Aromatase Inhibitors For Doping Control Purposes
… low libido, etc.). Similarly, the use of AIs (Aromatase Inhibitors) has also increased among athletes for identical reasons, and they are also banned by WADA within the same drug classification. This project’s overall goal was to develop and optimize a simple, sensitive and selective method for …
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Changes of breast cancer growth and metastasis in murine models modulated by an aromatase inhibitor, a low calcium diet or a high fat diet
… the hypothesis of this study is that the aromatase inhibitor letrozole may inhibit BC metastases to lungs by suppressing estrogen synthesis. BC growth on the bone micro-metastatic site and lung metastases were monitored in live animals via Bioluminescence Imaging (BLI). Effects of …
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Ethnic specific associations between body composition and metabolic risk and the role of sex hormones and aromatase among black and white South African women
… of oestrogen receptors (ERα and ERβ) and aromatase (CYP19A), and body fat distribution and insulin resistance (IR) among black and white women (study 2).Methods: Study 1: In 288 black and 197 white premenopausal women, dual-energy X-ray absorptiometry (DXA) and computed tomography (CT) …
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In vitro characterization of aromatase, estrone sulfotransferase and estrone sulfatase activities in the porcine placenta and endometrium at 30, 60 and 90 days of gestation
… to characterize the activities of three enzymes, aromatase, estrone (E1) sulfotransferase and E] sulfatase, in the porcine placenta and endometrium on d 30, 60 and 90 of gestation. These enzymes play key roles in determining in utero concentrations of estrogens. Days 30, 60 and 90 were chosen …
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Treatment Side Effects & Nonadherence among Women Taking Adjuvant Endocrine Therapy for Breast Cancer: The Role of Psychological Factors
… endocrine therapy with either tamoxifen or aromatase inhibitors significantly increases the risk of breast cancer recurrence. Side effects are a key driver of nonadherence to these treatments. As part of this doctoral research, two studies were conducted to explore the possibility that …
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Methadone metabolism in placentas from preterm pregnancies
… N-demethylated to EDDP, only, by human placental aromatase. This was confirmed through the use of chemical inhibitors and monoclonal antibodies raised against specific CYP isoforms. The affinity of methadone to CYP19 remained relatively unchanged throughout gestation. However, the activity of the …
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