Global ETD Search
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Showing 1 to 13 of 13 for “"Arid1a"”.
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Regulation of The Oxidative Stress Response By Arid1A
… in about 20% of all human cancers; in particular ARID1A is the most frequently mutated SWI/SNF subunit. <em>ARID1A</em> is a tumor suppressor gene, inactivating mutations in <em>ARID1A</em> are most frequently found in ovarian and endometrial cancers, specifically uterine corpus endometrioid …
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The role of Arid1a and Tet1 in ductal cell-driven liver regeneration
Title: The role of Arid1a and Tet1 in ductal cell-driven regeneration Author: Mikel Alexander Mckie The liver has several robust and potent mechanisms of repair after damage despite slow homeostatic turnover. In cases of extreme toxic damage, where the hepatocyte compartment is severely compromised …
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Arid1a Haploinsufficiency Initiates Neural Crest Transformation in a Mouse Model of Mycn-driven Neuroblastoma
… remodeler and tumor suppressor gene (TSG) ARID1A. Additional causal studies supported ARID1A’s candidacy as a putative 1p36 TSG in MYCN-driven NBL. This study aimed to causally test Arid1a loss during Mycn-driven NBL initiation through the development of a mouse model of high risk NBL.In …
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The impact of ARID1A loss on ER+ breast cancer: mechanistic insights and therapeutic opportunities
… breast cancer metastases harbour mutations in ARID1A, a critical subunit of the SWI/SNF chromatin remodelling complex. In 2020, Nagarajan et al. have shown that ARID1A mutations contribute to resistance to endocrine therapy in breast tumours while simultaneously increasing their sensitivity to …
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CHARACTERIZING THE ROLE OF THE CHROMATIN REMODELING COMPONENT ARID1A AS A SUPPRESSOR OF SPORADIC MAMMARY TUMORS IN MICE
… gene encoding the chromatin remodeling component Arid1a. Importantly, ARID1A is also frequently deleted (monoallelically) in a significant subset of human breast cancers (between 30-50%, depending on the specific study cited), based on data from The Cancer Genome Atlas (TCGA). I have characterized …
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The Functional Roles for SWI/SNF Chromatin Remodeling Complexes in Physiology and Disease
… diseases linked to chromatin-remodeling. ARID1A is a paralogous subunit that is commonly mutated in cancers and plays critical roles in liver regeneration. Chromatin remodeling mechanisms could be generally important for regeneration in other tissues. Since dynamic regulation of β-cell …
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EPIGENETIC MODIFICATIONS REGULATING LIVER HOMEOSTASIS AND TUMORIGENESIS
… tumor formation. Our data suggest a new role of Arid1A as one of the key players in HCC tumor development. In our study, we show that ARID1A predispose to HCC formation with the establishment of chronic inflammation. HCC derived from Arid1A deprivation are characterized by the selection of …
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The Effects of Chromatin Remodeling and Pseudokinase Activity on Liver Pathophysiology
… In this body of work, we show that loss of Arid1a, a DNA-binding component of the SWI/SNF chromatin remodeling complex, shifts hepatocyte metabolism to promote lipid accumulation in a manner similar to that seen in non-alcoholic fatty liver disease. We further explore the dynamics of the …
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Functional characterisation of driver events in ovarian clear cell carcinoma
… include HNF1B overexpression and inactivating ARID1A mutations. Importantly, these can also be found in a significant proportion of adjacent non-malignant endometriotic lesions and, therefore, are likely early events in OCCC pathogenesis. I hypothesised that the study of the functional …
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THE NRF-1/GABP/BRCA1 Transcriptional Network in Mammary Epithelial Differentiation
… determined that the SWI/SNF family members BRG1, ARID1A and BAF155 may participate in the complex that activates GABPbeta transcription in conjunction with NRF-1. Examination of NRF-1, GABP and BRCA1 in 3D culture models suggests that mammary epithelial differentiation is biphasic with the …
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Deubiquitinating Enzymes Promote Cancer Progression and Metastasis Via Regulating Protein Stability
… in <em>EZH2</em>-mutated lymphoma and <em>ARID1A</em>-mutated ovarian cancer, many cancers do not respond, because EZH2 can promote cancer independently of its histone methyltransferase activity. Here we identified ZRANB1 (also called Trabid) as an EZH2 deubiquitinase. ZRANB1 binds, …
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ING1 Impacts Ovarian Cancer by Altering EMT
… protein expression was associated with p16 and ARID1A levels and predicted better DSS in ovarian clear cell carcinoma (OCCC). Our data also suggested that high ING1/low N-cadherin expression predicts favourable disease-specific survival (DSS) in epithelial ovarian cancer. These data provide …
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Prevalence and fate of pro-oncogenic clones in the human colon
… for eight colorectal cancer driver genes; ARID1A, APC, CTNNB1, FBXW7, KRAS, PTEN, TP53 and SMAD4. Losses or gain of function in these genes were associated with biases in the processes of clone fixation and expansion, which determined their event burden in the tissue. However, by comparing …