Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Arginine methylation"”.
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Investigating The Role of Prmt1 and Arginine Methylation of Hsp70 In Human Pancreatic Cancer
<p>Protein arginine methyltransferase 1 (PRMT1) is the major arginine methyltransferase, which catalyzes the addition of one or two methyl groups to the arginine residues of its substrate proteins. The best-known substrate for PRMT1 is histone, while more and more non-histone proteins are now found …
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Developing and Using Methyl-Specific Antibodies to Study The Biological Roles of Arginine Methylation
<p>Arginine residues can be modified in three different ways to produce asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and monomethylarginine (MMA). These modifications are catalyzed by a family of nine protein arginine methyltransferases (PRMT1-9), which are of three types …
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Transcriptomics-based study reveals a novel link between arginine methylation and phosphate regulation in Saccharomyces cerevisiae
Hmt1 is the predominant arginine methyltransferase in yeast, involved in biological processes such as transcription, transcriptional regulation, nucleocytoplasmic transport of proteins and mRNAs and RNA splicing. Hmt1 is also known to mediate protein-protein and protein-RNA interactions. Despite …
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Exploring the role of the arginine-methylation writer-reader pair PRMT5/SND1 in JAK2-mutant myeloproliferative neoplasms
… for the methyltransferase activity of Protein Arginine Methyltransferase 5 (PRMT5) has been proposed in JAK2-mutant MPN, highlighting both a mechanism through which this mutation can drive disease progression and a potential mode of therapeutic intervention. Staphylococcal Nuclease …
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Context Dependent Regulation of Dicer Function During Oocyte-to-Embryo Transition
… elegans, I uncovered a regulatory role for the arginine-rich GRARR sequence of Dicer helicase domain motif VI, based around potential arginine methylation of this domain. I find that mutation to conserved arginine residues of the GRARR sequence disrupts the oocyte-to-embryo transition with …
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Crosstalk Between R1175 Methylation and Y1173 Phosphorylation Negatively Modulates Egfr-Mediated Erk Activation
… increasing evidence suggests that protein methylation is as important as other post-translational modifications in the regulation of various biological processes. This drives us to ask whether methylation is involved in the EGFR (epidermal growth factor receptor) signaling, a biological …
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An investigation of the epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal centre B cells
… to the EBV promoter, Wp which is silenced by DNA methylation. Genome-wide promoter arrays revealed that EBV infection of GC B cells is followed by methylation changes in a substantial number of cellular genes. These changes were not randomly distributed across the genome but clustered at certain …
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Kinetic Characterization, Inhibition, and Activity-Based Protein Profiling of Protein Arginine Methyltransferase 1
<p>Protein arginine methyltransferases (PRMTs) are SAM-dependent enzymes that catalyze the mono- and di-methylation of peptidyl arginine residues. Although all PRMTs produce mono-methyl arginine (MMA), type I PRMTs go on to form asymmetrically dimethylated arginine (ADMA), while type II enzymes …
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Molecular mechanisms behind the adjustment of phototrophic light-harvesting and mixotrophic utilization of cellulosic carbon sources in Chlamydomonas reinhardtii
… by two posttranslational modifications: i) by methylation of arginines in the glycine-arginine rich (GAR) motif of the protein, ii) by the thiol status of two C-terminal cysteines. This work provides evidence that arginine methylation represents a slowly reacting modulator, which is required …
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Characterizing The Recognition Motif and Novel Substrates of Carm1
… due to posttranslational modifications (PTMs). Arginine methylation is a common posttranslational modification, which is catalyzed by a family of nine protein arginine methyltransferases or PRMTs. These enzymes deposit one or two methyl groups to the nitrogen atoms of arginine side-chains. …
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The Regulation of Dna Methylation In Mammalian Development and Cancer
<p>DNA methylation is an essential epigenetic modification in mammals, as it plays important regulatory roles in multiple biological processes, such as gene transcription, maintenance of chromosomal structure and genomic stability, genomic imprinting, retrotransposon silencing, and X-chromosome …
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The post-translational methylation of arginine in the glycine arginine rich region of CHO nucleoin
… Nucleolin contains a conserved glycine arginine rich (GAR) domain near its carboxy terminus. GAR domains are defined by repeating tri-peptide, (arginine -glycine-glycine (RGG)) motifs. The arginine in the RGG motif is post-translationally modified by dimethylation on one of the two …
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A Study of The Snd1/Prmt5 Axis In Liver Cancer By Genetic Mouse Models
<p>Arginine methylation is an essential post-translational modification (PTM) in cells. Protein arginine methyltransferase 5 (PRMT5) is the primary enzyme that catalyzes symmetric dimethyl arginine (SDMA) and requires methylosome protein 50 (MEP50) for stability and enzymatic activity which are …
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Gain-of-Function Mouse Models to Investigate Biological Roles of Prmt6
… <p>Mentor: Dr. Mark T. Bedford</p> <p>Protein Arginine Methyltransferase 6 (PRMT6) is the histone tail writer that methylates the H3R2 (arginine 2 of histone H3) residue, which counteracts the activating H3K4me3 mark. PRMT6 has been shown to behave both as transcriptional co-repressor (i.e. …
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Role of Phosphorylation In The Regulation of Prmt5
… is a member of a group of proteins that mediate arginine methylation. It is involved in diverse cellular processes, including cell differentiation, splicing, transcription elongation and epigenetic silencing, and its expression is dysregulated in many cancers. Due to its pleiotropic functions, …
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Modulation of the activity of a key metabolic regulator Small Heterodimer Partner by post-translational modifications
… of SHP is increased by post-translational methylation of SHP at Arg-57 by protein arginine methyltransferase 5 in response to bile acids. The overall aim of this study is to delineate the molecular mechanism by which the post-translational modification of SHP regulates SHP functional …
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Biochemical and Functional Characterization of Novel RNA-binding Proteins Interacting with SMN in Motor Neuron-derived Cells
Spinal muscular atrophy is an autosomal recessive genetic disease that results from the loss and/or degeneration of alpha motor neurons in the lower part of the spinal cord. With ~ 1 in 6000 live births per year being affected, this disease is the second leading cause of infant death and is caused …