Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Arginase 1"”.
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Signaling Cross-Talk Regulating the Expression of Arginase 1 in Murine Macrophages
… resolution) phenotype. Expression of arginase 1 in macrophages is a key marker of the M2 phenotype. Arginase 1 expression is induced by interleukin 4 (IL-4), a cytokine secreted by Th2 helper cells. All-trans retinoic acid (ATRA) is a product of metabolism of dietary retinol (vitamin …
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An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue
… the expression of the immune modulating proteins Arginase-1 and iNOS in human lung biopsy samples. Previously, a 100% toxoplasmosis infection rate was found in 72 lung biopsy samples acquired from patients. This compared with 10% in healthy controls. Little is known of immune mechanisms acting on …
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Immunological control of toxoplasma gondii infection
… adaptive immunity. Parasite induced macrophage arginase-1 expression, for example, has been shown to be influential during T. gondii infection. Arginase-1 expression is negatively regulated by Map Kinase Phosphatase-2 (MKP-2), the second major aim of the project was to study the effect of MKP-2 …
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Immune related gene expression of parasite-resistant sheep during a Haemonchus contortus infection
… expressed Th2 genes such as interleukin-4 and arginase-1. Results from these two experiments indicate an adaptive immune response as early as 3 days post challenge infection in hair sheep. Thus, the rapid protective immunity generation of parasite-resistant hair sheep is a key difference by …
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TRANSFORMATION OF PRIMARY HUMAN HEPATOCYTES IN HEPATOCELLULAR CARCINOMA
… compared over time. Glypican-3, Heppar-1, Arginase-1 and CD-44 positivity were tested. The degree of invasiveness of cells acquiring neoplastic characteristics was studied with a trans-well migration assay. We observed that HCC cells maintained their morphology and unmodified neoplastic …
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Transient receptor potential vanilloid 1 exhibits neuroprotective effects in LPS-induced dopaminergic neuronal death in the suabstantia nigra in vivo.
… synthase (iNOS) and ROS while CAP increases Arginase 1 and CD206, M2 macrophage markers. In addition, CAP protected nigral DA neurons from LPS-induced neurotoxicity. This neuroprotective effect was reversed by capsazepine, a TRPV1 antagonist, indicative of TRPV1 involvement. However CAP could …
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Proteomic profiling of matched normal and tumour tongue biopsies from smokers and non-smokers. Oncoproteomic applications for oral tongue squamous cell carcinoma biomarker discovery
… up- and 431 down-regulated, respectively. Arginase-1 (ARG1), Keratin Type-2 Cytoskeletal 8 (KRT8), Lipocalin-1 (LCN1) and DNA replication licensing factor MCM2 (MCM2) were identified as biologically associated with smoking compared to non-smoking, providing viable targets for verification …
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Proteomic profiling of matched normal and tumour tongue biopsies from smokers and non-smokers. Oncoproteomic applications for oral tongue squamous cell carcinoma biomarker discovery
… up- and 431 down-regulated, respectively. Arginase-1 (ARG1), Keratin Type-2 Cytoskeletal 8 (KRT8), Lipocalin-1 (LCN1) and DNA replication licensing factor MCM2 (MCM2) were identified as biologically associated with smoking compared to non-smoking, providing viable targets for verification …
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In Vivo Studies on the Transcriptional and Posttranslational Regulation of the CCAAT/Enhancer Binding Protein Beta
… also show that the well-known regulation of the arginase 1 gene by C/EBPbeta is dependent on the ability of CREB to upregulate C/EBPbeta. FACS analyses on our bone marrow-derived macrophage population, showed that the cells are Mac1(+), F4/80(+) and Gr1(+), typical markers of Natural Suppressor …
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Role of Macrophages in Ocular Surface Fibrosis
… markers CD11b, F4/80, CD86, CD206, iNOS, and arginase-1. Our data demonstrates that irradiation caused an increase in macrophage pro-inflammatory cytokines IL-1b, TNF-a, and IL-6 and chemokine CCL2. While irradiation did not cause increase in M1 markers, there was a robust increase in M2 …
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Doxorubicin and T Helper Lymphocytes: Unexpected Allies Against Cancer
… species (ROS) production, and down-regulation of arginase-1 and indoleamine 2,3-dioxygenase (IDO) expression. Of therapeutic relevance, the frequency of effector lymphocytes (CD4⁺ and CD8⁺ T cells) or natural killer cells (NK) to suppressive MDSC ratios was significantly increased following …
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The bioactive role of omega-3 endocannabinoid epoxide regioisomers
… as increasing anti-inflammatory mRNA levels of arginase-1 (Arg-1) in LPS stimulated BV-2 microglia. Collectively, we showed that omega-3 eCB epoxide regioisomers differentially activate cannabinoid receptors and are anti-neuroinflammatory in microglial cell culture models.
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Charakterisierung von Knochenmark-generierten Makrophagen unter der Einwirkung von Vascular Endothelial Growth Factor
… wurden diese Befunde von Untersuchungen der Arginase-1, die bei der Proliferation von Bedeutung ist: Expression und Aktivität gingen durch VEGF zurück. In morphologischen Beobachtungen zeigten VEGF-behandelte BMDM in Wechselwirkung mit verschiedenen Bestandteilen extrazellulärer Matrix …
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IMPACT OF L-ARGININE TRANSPORTATION ON MYELOID-DERIVED SUPPRESSOR CELL FUNCTION
… is the metabolism of L-Arginine (L-Arg) by Arginase 1 (ARG1) and nitric oxide synthase 2 (NOS2). Therefore, we hypothesized that restricting MDSC uptake of L-Arg is a critical control point to modulate their suppressor activity. To this end, we have identified the mechanisms by which …
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Modeling of Cns Cancer With A Focus On The Immune Component
… to pursue a therapeutic target in the form of Arginase-1 using this system.</p> <p>An average GBM has roughly 30% infiltration of myeloid cells, the highest reported case at 70% infiltration, with some variation dependent on subtype. When we consider this fact in combination with the advent and …
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Interactions Between Microbial, Neuronal, and Immune Cells in the Digestive System
… through adrenergic receptor signaling, and an arginase 1-polyamine program. Notably, we found engagement of macrophage adrenergic receptor signaling to be dependent on local catecholamine release by gutinnervating sympathetic neurons. We further uncovered that these sympathetic neurons on their …