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Antikoagulation mit dem direkten Thrombinhemmer Argatroban bei COVID-19 und ECMO – Therapiemonitoring und -steuerung anhand verschiedener Gerinnungsparameter

Brinkmann, AndreaUniversität Ulm

ulm-diss Repository record for Antikoagulation mit dem direkten Thrombinhemmer Argatroban bei COVID-19 und ECMO – Therapiemonitoring und -steuerung anhand verschiedener Gerinnungsparameter (opens in a new tab)

FUNCTIONAL STUDIES WITH DIRECT ORAL ANTICOAGULANTS: INVESTIGATION OF THE REGULATION OF KEY BLOOD COAGULATION PROTEASES

Yeh, Calvin Hsiung2016

… the direct thrombin inhibitors dabigatran and argatroban yield divergent exosite-mediated thrombin binding to physiologic ligands like yA-fibrin, y'-fibrin, factor Va, and factor VIII, interactions that govern clot-mediated protection from AT inhibition, and the various functions of thrombin. …

mcmaster Repository record for FUNCTIONAL STUDIES WITH DIRECT ORAL ANTICOAGULANTS: INVESTIGATION OF THE REGULATION OF KEY BLOOD COAGULATION PROTEASES (opens in a new tab)

Designing Allosteric Inhibitors of Thrombin

Sidhu, Preetpal2016

… including polymeric heparin, warfarin, hirudin, argatroban and the recently approved dabigatran, aim to reduce thrombin activity. There are several binding domains on thrombin including the active site, anion-binding exosites I and II, and the sodium binding site. We hypothesized that thrombin …

vcu Repository record for Designing Allosteric Inhibitors of Thrombin (opens in a new tab)