Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Arenaviruses"”.
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Arenaviruses: the Role of Antigen Presenting Cells (APC) in Persistence and Immunopathology
Viruses are major contributors to global health crises. Many of the disease pandemics the world has experienced were caused by viruses from smallpox to Spanish flu, Ebola (Public health emergency of international concern), SARS, West Nile, Zika and currently SARS-CoV-2 the aetiology of COVID19. At …
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Arenavirus Attenuation Mechanisms
… the Soviet Union produced mass quantities of arenaviruses as part of their offensive weapons program (Alibek and Handelman, 1999). Junín virus, the etiological agent of Argentine hemorrhagic fever (AHF), causes up to 30% mortality in humans and is considered a National Institute of Allergy and …
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Genetic diversity and taxonomical relationships among the tacaribe serocomplex viruses (family arenaviridae)
… and the genomes of the North American arenaviruses are not a product of homologous genetic recombination between ancestors of the present-day South American arenaviruses. Study 2 --The nucleotide sequences of the small genomic segments of 12 strains of Junin virus, 7 strains of Machupo …
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Molecular characterization of rodent- and-shrew-borne viruses and the prevalence and intensity of infestation of small mammal fleas, in Namibia
… molecularly characterize novel Hantaviruses and Arenaviruses and to determine the prevalence and intensity of fleas on small mammals in selected areas of Namibia. Small mammals were trapped from six different regions and screened for both Hantavirus and Arenavirus. The regions are, namely, …
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A Recombinant Vesicular Stomatitis Virus Expressing the Junin Virus Glycoprotein for Arenavirus Countermeasure Development
Arenaviruses are pathogens of biodefense importance due to their potential for aerosol transmission and mortality rates reaching 30%. Here, we evaluated the use of a recombinant vesicular stomatitis virus expressing the Junin virus glycoprotein (rVSVΔG-JUNVGP) for the development of countermeasures …
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Pichinde virus infection of outbred Hartley guinea pigs and mice as small animal models of human Lassa fever
Arenaviruses are viruses that can cause severe and deadly hemorrhagic fever infections in Africa and South America, including Lassa virus that causes Lassa fever in several countries in west Africa. There are currently no vaccines and very limited therapeutics available for Lassa fever. There are …
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Using the host immune response to hemorrhagic fever Viruses to understand pathogenesis and improve diagnostics
… to infection by different strains of arenaviruses and filoviruses. Studying the host immune response has the potential to improve the diagnosis of viral hemorrhagic fevers and other diseases. It can also accelerate our efforts to understand the underlying molecular mechanisms that lead …
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ANIMAL MODELS FOR BEHAVIORAL CHANGES OR HEARING LOSS UPON ACUTE VIRUS INFECTIONS
… to study as models of neurological sequelae; arenaviruses and alphaviruses. Both of these viruses are important human pathogens and the cause of the long-term neurological damage, the related pathology and the mechanisms associated with sequelae have not been identified. Sensorineural hearing …
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Engineering the Nicotiana benthamiana secretory pathway for the production of Lujo virus vaccines and diagnostic tools
… not just for Lujo virus proteins, but for arenaviruses generally and potentially also other haemorrhagic fever-causing viruses. Future efforts should be directed towards addressing the barriers to plant production of complex viral antigens, and to further investigate the utility of …
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Biogenesis, Assembly and Intracellular Trafficking of Junin Arenavirus Envelope Glycoprotein Complex
An unusual feature in the arenavirus envelope glycoprotein complex (GP-C) is the presence of a myristoylated stable signal peptide (SSP) in addition to the receptor binding subunit G1 and the transmembrane fusion subunit G2. Genetic studies were employed to understand the structure-function of the …
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Biogenesis, Assembly and Intracellular Trafficking of Junin Arenavirus Envelope Glycoprotein Complex
An unusual feature in the arenavirus envelope glycoprotein complex (GP-C) is the presence of a myristoylated stable signal peptide (SSP) in addition to the receptor binding subunit G1 and the transmembrane fusion subunit G2. Genetic studies were employed to understand the structure-function of the …