Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 222 for “"Area under the curve"”.
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Dietary manipulation causes childhood obesity-like characteristics in pigs
… develop a porcine model for studying mechanisms underlying diet-induced childhood obesity. Pre-pubertal female pigs, age 35 d, were fed a high-energy diet (HED; n = 12), containing tallow and refined sugars, or a control corn-based diet (n = 11) for 16 wk. Initially, HED pigs self-regulated …
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Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics and dissolution kinetics in vitro
The efficacy of rifapentine, an oral antibiotic used in the treatment of tuberculosis, is reduced due to its degradation at gastric pH and low solubility at intestinal pH. We aimed to improve delivery properties in vitro by incorporating rifapentine into pH-responsive amorphous solid dispersions …
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Optimized approach to decision fusion of heterogeneous data for breast cancer diagnosis.
… combine various types of medical information together in order to optimize the overall diagnosis. To improve diagnostic performance, here we introduce an approach to optimize a decision-fusion technique to combine heterogeneous information, such as from different modalities, feature categories, or …
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ΜΕΛΕΤΗ ΤΗΣ ΒΙΟΙΣΟΔΥΝΑΜΙΑΣ ΙΔΙΟΣΚΕΥΑΣΜΑΤΩΝ ΑΣΠΙΡΙΝΗΣ ΠΟΥ ΚΥΚΛΟΦΟΡΟΥΝ ΣΤΗΝ ΕΛΛΑΔΑ
THE PHARMACOKINETIC BEHAVIOUR OF ORALLY ADMINISTERED PRODUCTS CONTAINING ACETYLSALICYLIC ACID WAS STUDIED IN HUMAN VOLUNTEERS. THE ADMINISTERED DRUGS, EACH OF WHICH CONTAINED 500 MG OF THE ACTIVE SUBSTANCE WERE THE FOLLOWING ASPIRIN R, COLFORT R, SALOSPIR R, NASPIN K, KALACALINE R AND CESPIRE R. …
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Use of modern machine learning techniques to predict the occurrence and outcome of corporate takeover events
The objective of this project is to use machine learning to predict the occurrence of corporate takeovers. The findings show that random forest yields the best predictions out-of-sample based on the area under the curve (AUC) metric. As such, 8 independent variables are considered statistically …
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The utility of two autism screening instruments in an urban low-income minority population
… that affects an estimated 1 in 68 children in the US. Early intervention can lead to improved long-term outcomes but access to these services is dependent on diagnosis. Diagnostic assessments are costly and time-consuming, making it impractical to conduct wide-scale assessments. Screening …
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Decision tree rule-based feature selection for imbalanced data
… on a decision tree rule and weighted Gini index. The effectiveness of the proposed methods is verified by classifying a dataset from Santander Bank and two datasets from UCI machine learning repository. The results show that our methods can achieve higher Area Under the Curve (AUC) and F-measure. …
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A Study of Shift Working Police Officers from Buffalo
… effects imposed by shift work. Using data from the Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) cohort, this study examined effects of long term or short term shift work on measures of diurnal salivary melatonin or cortisol, and depressive or stress-related symptoms as measured by …
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Quantification Of Vascular Parametric Indices Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging
… is a non-invasive method used to evaluate the biological activity in early clinical trials of novel drugs targeting the tumor vasculature using gadolinium-DTPA (Gd) as a contrast agent. However, it has some limitations, such as reproducibility, data acquisition times, the presence of noise, …
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Statistical model selection techniques for the cox proportional hazards model: a comparative study
The advancement in data acquiring technology continues to see survival data sets with many covariates. This has posed a new challenge for researchers in identifying important covariates for inference and prediction for a time-to-event response variable. In this dissertation, common Cox proportional …
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The digital symbol digit test : screening for Alzheimer's and Parkinson's
Neurodegenerative diseases affect the cognition of millions of people worldwide, degrading their quality of life and placing a burden on their families. Early identication can be extremely beneficial in treating or slowing down the onset of these diseases. One technique used to identify early …
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A multi-compartment pharmacokinetic model of docetaxel
Docetaxel is a clinically active chemotherapeutic agent commonly used in the treatment of solid tumors. It is administered within a micelle encapsulation, polysorbate 80, via intravenous infusion. Docetaxel is known to have a high degree of interpatient variability in its pharmacokinetic behaviour. …
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Gradient Boosted Decision Tree Application to Muon Identification in the KLM at Belle II
We present the results of applying a Fast Boosted Decision Tree (FBDT) algorithm to the task of distinguishing muons from pions in K-Long and Muon (KLM) detector of the Belle II experiment. Performance was evaluated over a momentum range of 0.6 < p < 5.0 GeV/c by plotting Receiver Operating …
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The effect of whey protein on insulin and glucose responses in recreationally active males
The objective of the study was to analyze the insulinotropic and glycemic responses of hydrolyzed whey protein concentrate (WPH) in comparison to its intact form, whey protein concentrate (WPC), and carbohydrate control (CHO) in recreationally active young men over a 3-hr postprandial period. …
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A multi-compartment pharmacokinetic model of 5-fluorouracil and dihydrofluorouracil
… biotransformed to dihydrofluorouracil (DHFU) by the dihydropyrimidine dehydrogenase enzyme (DPD) that catalyzes the reduction of uracil and thymine. This research involves the development of intensive quantitative compartment models that predict the time course of 5-FU and DHFU in the body using …
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Resting Microvascular and Autonomic Function in Relation to Age and Sex Hormone Concentrations
This study assessed the influence of estradiol, progesterone, testosterone and age on resting microvascular and autonomic function in younger and older males and females. Microvascular function was assessed with reactive hyperemia using the microvascular function index (MFI) technique (5mins …
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A Comparison of Presence Only Suitability Models to Accurately Identify Prehistoric Agricultural Fields in Western New Mexico Through Remote Sensing
This project aims to provide greater understanding of the agricultural practices of prehistoric cultures throughout the arid and semi-arid environments of western New Mexico by developing a remote sensing suitability model that will identify prime environments for a specific form of agricultural …
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The combined effects of acute aerobic exercise and omega-3 supplementation on glucose metabolism in healthy, normoglycemic men
This study evaluated the effects of acute aerobic exercise and n-3 supplementation on glucose, insulin, and c-peptide concentrations in normoglycemic men. Eleven sedentary, healthy men completed four interventions: rest without n-3 (CON), exercise without n-3 (EX), rest with n-3 (SUP), and exercise …
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The Effects of Two Modes of High-Intensity Intermittent Exercise on Postprandial Metabolism
<p>The purpose of this study was to see if exercise in the form of Tabata or Sprinting would lower postprandial lipemia and glycemia. Tabata was composed of body-weight exercises. Both Tabata and Sprinting consisted of 5 rounds with each round lasting 4 minutes and included movements performed for …
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Implementation of a New Sigmoid Function in Backpropagation Neural Networks.
<p>This thesis presents the use of a new sigmoid activation function in backpropagation artificial neural networks (ANNs). ANNs using conventional activation functions may generalize poorly when trained on a set which includes quirky, mislabeled, unbalanced, or otherwise complicated data. This new …
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