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Showing 1 to 16 of 16 for “"Arachidonic acid Metabolism"”.
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Vitamin E and arachidonic acid metabolism in cultured human endothelial cells.
A novel approach to study the metabolism of nutrients in human cells was developed. The incorporation and depletion of 2R,4$\sp\prime$R,8$\sp\prime$R-$\alpha$-tocopherol (RRR-$\alpha$-T), a natural form of vitamin E, and its subsequent effect on the metabolism of arachidonic acid were conducted on …
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Modulation of Arachidonic Acid Metabolism in Rat Peritoneal Macrophages Through Nutritional Means
Embargo set by: Seth Robbins for item 78657 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs
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The effect of the reducing agent triphenylphosphine on arachidonic acid metabolism by prostaglandin H2 synthase
… H2 synthase (PGHS) catalyzes the conversion of arachidonic acid to prostaglandin endoperoxide (PGH2), which is a precursor to a variety of prostaglandins that function as hormones. Gas chromatography combined with mass spectrometry is employed to look for the novel products produced by reaction …
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Arachidonic acid metabolism by early ovine embryos and the role of prostaglandins in one aspect of embryonic development
… early ovine embryos were capable of metabolizing arachidonic acid. Cyclic ewes were estrous synchronized with 6⍺-methyl-17β-hydroxy progesterone acetate (MPA) pessaries, superovulated with follicle stimulating hormone (FSH) and bred artificially. Embryos were collected on d 4, 8, 10, 12 or 14 of …
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Involvement of Cytochrome P450 1A in the toxicity of aryl hydrocarbon receptor agonists : alteration arachidonic acid metabolism and production of reactive oxygen species
… scup (Stenotomus chrysops), alteration of arachidonic acid (AA) metabolism and production of reactive oxygen species (ROS). In scup hepatic microsomes, cytochrome P450s including CYP1A and CYP2B-like proteins catalyzed regioselective metabolism of AA to eicosatrienoic and …
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Arachidonate oxidation metabolite profiles for myoglobin and a structurally altered form of myoglobin produced in muscle disease or trauma
… of this type of reaction with arachadonic acid have previously been determined, with Mb generating greater quantities of aldehyde products than Mb-H. The focus of this research was to establish the presence of some products from the reactions of Mb and Mb-H with GPC (which contains …
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The role of reactive oxygen species in the endothelium derived hyperpolarising factor response
… to be presented suggest that ROS produced by arachidonic acid metabolism via CYP 2C9 promote EDHF mediated relaxation mainly by enhancing the inositol trisphosphate-mediated release of Ca2+ from endothelial stores.
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Cysteinyl leukotriene receptor 1 as a host determinant for susceptibility to cutaneous leishmaniasis in a mouse model
… mast cells and dendritic cells during arachidonic acid metabolism, are hypothesized to induce a protective response during cutaneous leishmaniasis. However, as LTs consist of cysteinyl leukotrienes (CysLTs- LTC4, LTD4, LTE4) and LTB4, it is unclear which LT subclass is responsible for …
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Altered Hemodynamic Control in the Skeletal Muscle Microcirculation in the Metabolic Syndrome: The Emergence of a new Attractor
… syndrome are oxidant stress-based alterations to arachidonic acid metabolism and increased sensitivity to adrenergic stimulation. However, it remains unclear if the altered microvascular reactivity that presents with metabolic syndrome plays a role in the perfusion: demand mismatch that …
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Role of 5-Lipoxygenase in Interleukin-4-Induced Oxidative Stress and Inflammation in Vascular Endothelium
… oxygen species (ROS) via metabolic pathways of arachidonic acid. Although 5-LOX has been implicated in the development of atherosclerosis, it remains unclear whether 5-LOX-mediated ROS generation is associated with IL-4-induced MCP-1 expression in vascular endothelium. The present study was …
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Antiplatelet and antihypertensive actions of ridogrel
… contraction. Furthermore, the redirection of arachidonic acid metabolism toward the synthesis of prostacyclin, and the enhancement of intracellular cAMP generation, would favour vasorelaxation, reduce shear stress and increase erythrocyte deformability in the micro-circulation. It remains to …
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Role of the Leukotriene B4 Metabolic Pathway in Human Pancreatic Cancer
… pancreatic cancer growth with dietary fatty acid intake, especially intake of m-6 polyunsaturated fatty acids (PUFAs), such as iinoleic acid (LA) and arachidonic acid (AA), which enhance tumorigenesis through the production of eicosanoids. On the other hand, w-3 PUFAs, such as …
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IMPORTANCE OF SUPPLYING DAIRY COWS WITH ESSENTIAL FATTY ACIDS (EFA) AND CONJUGATED LINOLEIC ACIDS (CLA) DURING THE TRANSITION PERIOD ON METABOLISM AND HEALTH
… supplementation with essential fatty acids (EFA) and conjugated linoleic acids (CLA) has been shown to influence different aspects of lipid and energy metabolisms as well as markers of immune homeostasis in dairy cows. This study aimed at investigating the synergistic effects of EFA, …
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The role of oxygen free radicals in the endotoxic shock induced myocardial dysfunction and cellular injury
… of oxygen free radicals (OFRs) and hypochlorous acid (HOCl). During ET-shock, OFRs could also be produced from other sources including auto-oxidation of catecholamines, xanthine-xanthine oxidase enzyme system during ischemia, and arachidonic acid metabolism. An increase in the levels of OFRs …
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Enzymology of lipid metabolism by CYP2J2 as controlled by multiple-ligand binding events
… in the body. Specifically, polyunsaturated fatty acids (PUFAs) are transformed by three main pathways: the cyclooxygenase, lipoxygenase, and cytochrome P450 (CYP) epoxygenase pathways. Arachidonic acid is the canonical lipid mediator and it is transformed by the cyclooxygenase and lipoxygenase …
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MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS
… is a potent platelet agonist generated through arachidonic acid metabolism in platelets. TXA2 thus, generated after platelet activation acts as a positive feedback mediator along with ADP. Under physiological conditions, platelet activation leads to thrombin generation through coagulation …