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Showing 1 to 20 of 41 for “"Arachidonic acid (AA)"”.

  1. Influence of the reducing agent triphenylphosphine on cyclooxygenase-1 metabolism of arachidonic acid

    Sidhu, Rohini2010

    … (COX) metabolizes the polyunsaturated fatty acid arachidonic acid (AA) to PGG2, a cyclic endoperoxide that also contains a hydroperoxide, which is subsequently reduced to an alcohol in the enzyme to yield PGH2. Reactions catalyzed by COX-1 are significantly influenced by lipid hydroperoxides. …

    emich Repository record

  2. Chemical Methods for Studying the Biosynthesis of Lantibiotics and Prostaglandins

    Okeley, Nicole MarieUniversity of Illinois at Urbana-Champaign2015

    Prostaglandin H Synthase (PGHS) converts arachidonic acid (AA) into the first intermediate in the synthesis of prostaglandins via a radical mechanism. Prostaglandins play a number of roles in the body, including the regulation of blood flow to certain organs, controlling transport across membranes, …

    uiuc Repository record

  3. D2R Dopamine Receptor Mediates Changes in Dual Specificity Phosphatase Expression in a Small Cell Lung Cancer Cell Line

    Lattimer, Scott Lemar2016

    … were also induced by treatment with exogenous arachidonic acid (AA). In addition, the NPA mediated increases in these genes was inhibited by 5,8,11,14‑eicosatetraynoic acid (ETYA) an AA analog and inhibitor of downstream activity, suggesting NPA induction of these three genes is AA dependent. …

    tenn-hsc Repository record

  4. Quantification of fatty acids over the gametogenic cycle of striped bass (Morone saxatilis) with varying dietary levels of DHA, EPA and AA

    Dickey, Lisa Ann2000

    … the effects of dietary treatments on the fatty acid composition of striped bass (Marone saxatilis) blood, liver and ovary over the course of the gametogenic cycle. Striped bass were fed experimental diets in which docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and arachidonic acid (AA) …

    maryland Repository record

  5. Neuroprotection of AG490 in Oxidative Stress-induced Neuronal Death

    김, 아영2007

    … (BSO), N-methyl-D-aspartic acid (NMDA), and arachidonic acid (AA). Particularly, AG490 completely blocked H2O2-induced neuronal death. To explore the protective mechanism of AG490, the involvement of JAK2 signal pathway, the regulation of reactive oxygen species (ROS), and …

    ajou Repository record

  6. The effects of Omega-3, Omega-6 Polyunsaturated Fatty Acids (PUFAs) and Vitamin E on patients with the remitting-relapsing (RR) form of Multiple Sclerosis (MS) in Cyprus

    Loucaides, George N.London Metropolitan University2016

    … Omega (ω)-3/ω-6 polyunsaturated fatty acids (PUFAs) and some vitamins have been shown to reduce the number and severity of relapses and the overall progression of disability in multiple sclerosis patients, however clinical trials remain inconclusive due to a plethora of reasons. In this …

    london-metro Repository record

  7. Polyunsaturated fatty acids and immune cell functions

    Pinto, EvaUniversity of Greenwich2007

    … positive relationship between membrane AA and TGF-ß1 indicating that it is the individual long chain (LC) PUFA, i.e. AA that regulate the levels of TGF-ß1. Investigation of the effects of n-6 and n-3 PUFAs on normal healthy PBMC production of TGF-ß1 in vitro showed that PBMC in the …

    greenwich

  8. The Group IVA Cytosolic Phospholipase A2/C1P Interaction and Its Role in Eicosanoid Synthesis and Inflammation

    Mietla, Jennifer A.2019

    … production of eicosanoids is the liberation of arachidonic acid (AA) from membrane phospholipids by a phospholipase A2 (PLA2). The major phospholipase involved in this liberation of AA during the inflammatory response is group IVA cytosolic phospholipase A2 (cPLA2α). Previous studies from our …

    vcu Repository record

  9. Group IV Cytosolic Phospholipase A2α Is Critical for the Development of Angiotensin II-Induced Hypertension and Associated Pathogenesis

    Khan, Nayaab Shehbaz2016

    … cytosolic phospholipase A2α and releases arachidonic acid (AA) from tissue phospholipids. AA metabolites mediate or modulate one or more renocardiovascular effects of this peptide and have been implicated in hypertension. Since AA release is the rate limiting step in eicosanoid production, …

    tenn-hsc Repository record

  10. Effect of Fatty Acid Modification on Prostacyclin Production in Cultured Human Endothelial Cells (Arachidonate, Elcosapentaenoate)

    Basgall, Edward JosephUniversity of Illinois at Urbana-Champaign2015

    … was used to compare the effects of endogenous arachidonic acid (AA) and eicosapentaenoic acid (EPA) on prostacyclin synthesis. Supplemental levels of fatty acids (20-150 (mu)M) were supplied as sodium salts bound to bovine serum albumin (3:1 mole ratio) and added to M-199 with 20% fetal bovine …

    uiuc Repository record

  11. Prophylactic Enrichment of Enterocyte Phospholipids with Polyunsaturated Fatty Acids Fed to Suckling Piglets.

    Hess, Holly Aline2007

    … formulas with long-chain polyunsaturated fatty acids (PUFA) in 2002, including arachidonic acid (AA) at ˜ 0.5% of total fatty acids. This study is the first in a series that will examine effects of supra-physiological supplementation of AA on intestinal health. The objective was to determine the …

    ncsu Repository record

  12. The importance of long chain polyunsaturated fatty acids for fetal immune system maturation and function

    Moodley, TherishneeLondon Metropolitan University2007

    Long chain polyunsaturated fatty acids (LCPUFAs) are important structural components in the cell membrane and a deficiency in these fatty acids have been linked to clinical complications. In addition, omega 3 and omega 6 LCPUFAs are biologically active substrates for the synthesis of regulators of …

    london-metro Repository record

  13. Protective Effects of Yuzu and Its Component against Cardiovascular Disease

    유, 혜연2015

    … Yuzu and hesperidin inhibited collagen-, arachidonic acid (AA)-, ADP- and thrombin-induced rat platelet aggregation in vitro and ex vivo. Naringin also inhibited platelet aggregation induced by collagen, AA, or thrombin, but not by ADP. The oral administration of yuzu or hesperidin …

    ajou Repository record

  14. FADS2 expression modulates effect of dietary polyunsaturated fatty acids on western diet-induced glucose intolerance

    Linde, Peter, author, Chicco, Adam, advisor, Melby, Christopher, committee member, Bouma, Gerrit, committee memberColorado State University. Libraries2017

    Fatty Acid Desaturase 2 (FADS2) haplotypes associated with hyperactivity of its gene product, delta-6-desaturase (D6D), are associated with obesity and type-2 diabetes in humans. D6D regulates long-chain polyunsaturated fatty acid (PUFA) biosynthesis and is upregulated in several rodent models of …

    colostate Repository record

  15. Fatty Acid Regulation of NLRP3 Inflammasome Activity

    Liang, JonathanUniversity of Cambridge2021

    … of cell death called pyroptosis. Saturated fatty acids (SFAs) are known to activate the NLRP3 inflammasome but the intracellular pathways by which this activation occurs are incompletely described. I hypothesized that SFAs activate the NLRP3 inflammasome through different intracellular pathways …

    cambridge Repository record

  16. A Missing link between lipid metabolism, inflammation and apoptosis: Phospholipase A2-activating protein (PLAA)

    Fan ZhangThe University of Texas Medical Branch2009

    Phospholipase A2-Activating Protein (PLAA) is a novel signaling molecule that regulates the production of arachidonic acid (AA), prostaglandin E2 (PGE2) and TNF-¦Á. Literature suggests that PLAA could be involved in inflammatory responses and apoptosis. However, the in situ function of PLAA is …

    utmb Repository record

  17. The Signaling Pathway of Oxysterol-Induced Apoptosis in Macrophages.

    Freeman, Natalie Elaine2005

    … A<sub>2</sub> resulting in the release of arachidonic acid (AA). Inhibition of AA metabolism has been shown to protect macrophages from oxysterol-induced apoptosis. The current study explores the steps in the oxysterol-induced apoptosis signaling pathway in murine macrophages subsequent to …

    etsu Repository record

  18. Investigating the Relation Between Genetic Variation in FADS1 & FADS2 with the LCPUFA Content of Extracellular Vesicles from Human Milk

    Paterson, Natalie2024

    … of long-chain polyunsaturated fatty acids (LCPUFA) in human milk EVs. As integral components of the lipid membrane, the specific composition or balance of LCPUFAs may impact the bioavailability of EVs in newborns consuming human milk. The objective of this study was to determine the …

    chapman Repository record

  19. Protein-protein interactions and mechanistic insights for CYP2J2 and CYP5A1

    Meling, Daryl DuaneUniversity of Illinois at Urbana-Champaign2016

    … formed from the oxidation of -3 and -6 fatty acids. CYP2J2 and CYP5A1 are two key enzymes involved in the formation of eicosanoids. CYP2J2 is a classical P450 which requires transfer of electrons from its obligate redox partner, cytochrome P450 reductase (CPR). Here the triphasic kinetics of …

    uiuc Repository record

  20. Involvement of Cytochrome P450 1A in the toxicity of aryl hydrocarbon receptor agonists : alteration arachidonic acid metabolism and production of reactive oxygen species

    Schlezinger, Jennifer J.Massachusetts Institute of Technology and Woods Hole Oceanographic Institution1998

    … scup (Stenotomus chrysops), alteration of arachidonic acid (AA) metabolism and production of reactive oxygen species (ROS). In scup hepatic microsomes, cytochrome P450s including CYP1A and CYP2B-like proteins catalyzed regioselective metabolism of AA to eicosatrienoic and …

    woods-hole Repository record

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