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Showing 1 to 17 of 17 for “"Arabinogalactan"”.
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IDENTIFICATION OF THE ROLE OF [METHYL]GLUCURONIC ACID ON ARABINOGALACTAN POLYSACCHARIDES IN ARABIDOPSIS THALIANA
Arabinogalactan proteins (AGPs) are proteoglycans heavily substituted by arabinogalactan polysaccharides. These are composed of arabinose and galactose, and minor sugars such as glucuronic acid (GlcA), fucose and xylose. The arabinogalactan polysaccharides do not decorate classical AGPs …
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Molecular characterisation and functional properties of gum arabic
… consists of:- a: a major protein deficient arabinogalactan representing900/6o f the total gum mass: b: a high molecular mass, protein rich (100A protein)component, designated as an arabinogalactan-proteincomplex which accounts for 9% of the total gum:c: one or more protein enriched (50% …
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Molecular and biochemical characterisation of novel glycosyltransferases in Mycobacterium tuberculosis
The cell wall mycolyl-arabinogalactan-peptidoglycan complex is essential in mycobacterial species, such as Mycobacterium tuberculosis and is the target of several antitubercular drugs. Arabinofuranosyltransferase enzymes, such as EmbA, EmbB, and AftA, play pivotal roles in the biosynthesis of …
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Probing the Mycobacterial Cell Envelope: CRISPR interference-mediated investigation of two essential genes in the galactan biosynthetic pathway
… cell envelope is the heteropolysaccharide, arabinogalactan. This molecule is comprised of the galactan and Arabinan units, forming the characteristic cell wall core of mycobacterial species. Large scale drug screens have shown that arabinogalactan strains are sensitised to known anti- TB …
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Carbohydrate hydrolases and their role in bread production
… of arabinoxylans with smaller levels of arabinogalactan often present. Commercial pentosanase preparations contain a range of xylanase and arabinase activities that are believed to act synergistically to produce the improving effects observed in breads when these preparations are added. …
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Design and synthesis of inhibitors of dTDP-D-glucose 4,6-dehydrate (Rm1B), and enzyme required for dTDP-L-rhamnose production in M. tuberculosis
… essential role in linking the peptidoglycan and arabinogalactan portions of the mycolic acid-arabinogalactan-peptidoglycan complex, a significant part of the mycobacterial cell wall. The mounting level of biochemical understanding of this pathway and its importance in bacterial cell wall …
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Defining the role of cellulose synthase-like M genes in the plant cell wall
… may have a role in the synthesis of type II arabinogalactan linkages of pectin RG-I or AGP (arabinogalactan proteins). However, the glycosylating sugar is unspecified. Previous studies have also shown that a subset of CslM genes, CslM2, adds a glucuronic acid to the C-3 position of …
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Biochemical and molecular characterisation of cell wall glycosyltransferases in Mycobacterium tuberculosis
… as lipomannan (LM), lipoarabinomannan (LAM) and arabinogalactan (AG). In this study, we have analysed several uncharacterised open reading frames, which encode for putative glycosyltransferases from M. tuberculosis and deleted their respective orthologues in C. glutamicum. Mutant phenotypes were …
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Chemical Probes and Strategies to Study Mycobacterial Cell Envelope Assembly
… activity of native glycosyltransferases to probe arabinogalactan and mannose-containing glycolipids. Building upon prior work using lipid-linked probes to label mycobacterial arabinan, Chapter 2 details the development of azido-functionalized farnesyl phosphoryl mannose (AzFPM) probes that mimic …
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Channel-forming proteins in the cell wall of amino acid-producing Corynebacteria
… walls of most actinomycetes contain besides an arabinogalactan-peptidoglycan complex large amounts of mycolic acids. This three-layer envelope is called MAP (mycolyl-arabinogalactan-peptidoglycan) complex and it represents a second permeability barrier beside the cytoplasmic membrane similar to …
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Barriers to tuberculosis drug discovery: the mycobacterial cell wall
… layers encapsulate the cell membrane, including arabinogalactan chains and mycolic acids that are covalently bonded to the peptidoglycan layer, resulting in a highly selectively permeable barrier that is unique to this genus. The current treatment for tuberculosis (TB) utilizes antibiotics that …
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An investigation of the molecular structure, composition and biophysical properties of gum Arabic
… antibody) indicated clear labelling of arabinogalactan-proteins present in the gums harvested from A. senegal, the labelling of the A. seyal sample was inconclusive. In summary, the data presented represents the first detailed comparison of the structure, composition and physicochemical …
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Investigation of the heat transfer enhancement effects of nanofluids in process heating and cooling
… bromide (CTAB), sodium lauryl sulphate (SDS) and Arabinogalactan (ARB) to create 20 combinations of nanofluids. ARB as a surfactant kept C/H₂O and CuO/EG nanofluid stable for 29 days. Whereas CTAB and SDBS surfactants kept C/H₂O and Al₂O₃/H₂O nanofluids stable for 17 and 11 days respectively. …
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Exploring the chemical properties of polyphenols in cold-hardy grape cultivars
… of the natural sugar side chains, such as arabinogalactan proteins (AGP). Such a shift in composition was thought to affect tannin-polysaccharide interactions, potentially facilitating greater tannin extraction and influencing the wine's sensory properties. Understanding human perception of …
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The role of abscisic acid in the defence response of tomato (Solanum lycopersicum) to the necrotrophic pathogens Botrytis cinerea and Erwinia chrysanthemi
… in pectin distribution and in the presence of arabinogalactan proteins, which are presumably involved in signalling at the cell surface. Further experimental data will be needed expand our knowledge sitiens defence elicitation. In conclusion, we have shown that ABA-deficiency in tomato results …
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Discovery of Natural Product-based Antimycobacterial Agents Effective against Non-replicating Bacilli
<p>New antimycobacterial molecules that kill non-replicating Mycobacterium tuberculosis (Mtb) were identified by screening libraries of synthetic natural products. De novo screening of a 400-membered library of aurachin RE analogs resulted in discovery of UT-317 ((R)-20). UT-317 is a selective …