Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Aquaporin-1"”.
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Developing Novel Conservative Treatments For 2 Endometrial Cancer By Targeting Aquaporin-1
… invasiveness by pharmacologically targeting aquaporin 1, a transmembrane protein serving as dual water and ion channels and demonstrating high expression across various solid cancer types. This thesis uses two approaches to identify novel conservative treatment of EC. In the first approach, …
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Contribution of Causal Aquaporin-1 Mutations to the Pathobiology of Pulmonary Arterial Hypertension
… rare causative heterozygous variants in the Aquaporin-1 (AQP1) gene were identified among a small subgroup of PAH patients. AQP1 is a water channel protein critical for maintaining endothelial cell integrity and fluid homeostasis. The primary aim of this thesis is to provide insight into the …
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Pharmacologically impeding glioblastoma tumour motility through simultaneous inhibition of aquaporin-1 and ion channels
… pathways that control cellular motility include aquaporins and ion channels. These protein classes could therefore be prime candidates as pharmacological targets to restrain cell motility in glioblastoma. Identifying optimal combinations of inhibitory agents to use against selected channel …
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Pharmacological Modulation of Cancer Migration and Invasion Through Targeting AQP1 Ion and Water Channel Activity
… are the leading causes of cancer-related deaths. Aquaporin-1 is a dual water and ion channel that is upregulated in many aggressive cancers including colon, breast, and brain cancer; aquaporin-1 enhances cell migration, invasion and metastasis in these cancer types. Other aquaporins with water …
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Selective molecular transport in nanopore systems
… rejection of truncated human membrane protein aquaporin-1 (AQP) in simulation. Finally, I present MD simulation of truncated AQP as a voltage-gated ionic diode and as the functional element of a double-membrane ionic pump.
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Imaging biological water permeability barriers using CARS microscopy
… of mice deficient in the water channel protein aquaporin 1 (AQP1) were examined to evaluate the role of AQP1 in vascular water permeability. A layered hydrogel imaging phantom was constructed from poly(ethylene glycol) diacrylate (PEGDA) to validate ability of water-CARS microscopy to determine …
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AQP1—A REGULATORY FACTOR ASSOCIATED WITH BROWN ADIPOSE TISSUE SILENCING TO COMBAT OBESITY AND METABOLIC DISEASE
… Here, I present a putative BAT-silencing factor, aquaporin-1 (AQP1), as a novel therapeutic target to protect subjects against DIO and metabolic dysfunction. Interrogation of in vivo metabolic parameters revealed BAT-specific AQP1 knockout mice (AQP1-KO) on high fat diet (HFD) experienced reduced …
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Modeling and Simulating Biomolecular Machineries at Atomic Scale and Beyond
… translocation; (2) a membrane channel protein Aquaporin-1 (AQP1), conducting water through its individual monomeric pores, for which we have proposed a feasible mechanism of gating and ion conduction in its tetramerical central pore; (3) a four-way DNA junction (Holliday junction), a central …
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Towards Understanding Membrane Protein Folding and Stability with Solid-State NMR and Hydrogen/Deuterium Exchange
… the unfolding energy landscape of human aquaporin-1 (hAQP1), a homotetrameric transmembrane water channel. Site-specific exchange rates were probed at four different temperatures and the activation energies were extracted, from which we constructed an unfolding energy landscape. We …
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The Convergence of Accelerated and Physiological Vascular Ageing: A Multi-Omic Analysis of 2D and 3D in vitro models of Progeria
… 2D and 3D accelerated ageing models identified aquaporin 1 (AQP1) as a potential therapeutic target in the prevention and treatment of age-related vascular dysfunction. Here, we showed that AQP1 is upregulated in both accelerated and physiological ageing, and is differentially expressed in …
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Characterizing Changes in the Brain During Hydrocephalic Development and Exploring Potential Treatment Strategies
… wildtype (Tmem67+/+). These cells also contain aquaporins (AQP), aquaporin-1 (AQP1) and aquaporin-4 (AQP4), important in regulating CSF and interstitial fluid (ISF). Increased fluorescent intensity of AQP4 in the subventricular zone and increased AQP1 apical localization and protein amount in …
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Sensing in biological systems
… which correlates with ion movement through aquaporin transmembrane channels. These results suggest that the aquaporin-1 (AQP1) ion channel could be a novel candidate for therapeutic interventions to manage metastasis in AQP1-dependent cancers. Appendix B: The themes of tailored selectivity …