Global ETD Search
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Showing 1 to 5 of 5 for “"Aqp2"”.
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Developmental Origins of Renal Connecting Tubule and Collecting Duct: Role of Aqp2+ Progenitor Cells
… virtually unknown.</p> <p>We generated two Aqp2 lineage tracing mouse models. In these models, <em>Aqp2Cre</em> transgene drives Cre expression by the <em>Aqp2 </em>promoter to exclusively either inactivate histone H3 K79 methyltransferase <em>Dot1l</em> (<em>Dot1l<sup>f/f …
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Modulation of the aquaporin-2 localization in renal principal cells
… kinase A, PKA), the water channel aquaporin-2 (AQP2) is redistributed from intracellular vesicles into the plasma membrane of renal collecting duct principal cells. Its insertion into the plasma membrane induces the water reabsorption from primary urine and fine-tunes body water homeostasis. …
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Analysis of the role of the mineralocorticoid receptor in renal principal cell sodium reabsorption in vivo
… mouse DNA harbouring 156 kb of the aquaporin 2 (AQP2) gene was used to drive the expression of Cre recombinase in principal cells (AQP2Cre mice). Mice carrying a conditional MR allele were crossed with AQP2Cre mice to obtain mutant (MRAQP2Cre) mice. MRAQP2Cre mice developped normally under …
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An in vivo study of novel genetic modifiers in autosomal recessive polycystic kidney disease (ARPKD)
… RNA-sequencing analysis also identified Aqp2, Foxf1 and Igfbp2 as novel Pkhd1 targets in the lung, as well as dysregulation of STAT3 signalling in Pkhd1T37M/T37M mice. Together, this data further highlights potential mechanisms of action for the lung phenotype and sets the ground for …
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Renal Epithelial Sodium Channel (ENaC) Regulation of Pregnancy Mediated Hemodynamic Adaptations: Mechanistic Insights
… transporters in the distal nephron (NCC, ENaC, AQP2) was similar to pregnancy, however differences were seen in pre-macula densa transporters (NHE3, NKCC2). The similar changes observed in the distal convoluted tubule and renal collecting duct promote Na and water retention. The changes in these …