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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Apyrase"”.
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Cardioprotective treatment strategies
… ATP is degraded into adenosine by the enzyme apyrase, and adenosine possesses cardioprotective properties. ADC-1004 is an antagonist of the receptor to the activated complement factor C5a. Hypothermia has been shown to suppress the development of I/R injury. In this thesis, the …
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The relevance of adenylate levels and adenylate converting enzymes on metabolism and development of potato (Solanum tuberosum L.) tubers
… in the plants’ apoplast. Presumably, apoplastic apyrases are involved in this signaling by hydrolyzing the signal mediating molecules ATP and ADP to AMP. This PhD thesis focused on the role of adenylates on metabolism and development of potato (Solanum tuberosum) by using reverse genetics and …
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The Role of Extracellular ATP in Dictyostelium discoideum Growth and Development
… growth and development. Treatment of cells with apyrase, a potato enzyme known to degrade ATP, did not affect the rate of growth, but led to a delay in the appearance of streams during development. This delay corresponded with the formation of “clumps” of cells, but no evidence could be found …
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Integrative analysis of high-throughput biological data: shrinkage correlation coefficient and comparative expression analysis
… We evaluated the gene expression changes of apyrase-suppressed RNAi mutants that had been grown in the light and in the darkness, using the NimbleGen Arabidopsis thaliana 4-Plex microarray, respectively. We compared the two sets of large-scale expression data and identified genes whose …
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An Ecological, Molecular, and Biochemical Comparison of Aedes Triseriatus (Say), the Vector of LaCrosse Virus, With Its Sibling Species, Aedes Hendersoni Cockerell
… biochemical studies of my thesis identified the apyrase, an inhibitor of platelet aggregation, of Ae. triseriatus and Ae. hendersoni . Apyrase activity was characterized from both species, but no difference in activities was observed. Some differences in apyrase levels after a blood meal were …
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The role of nucleotides and the P2X7 receptor in radiation induced bystander effect
… directly irradiated themselves. The reagents apyrase which breaks down ATP and ADP, ARL67156 which is a selective inhibitor of certain ectonucleotidases and A438079 which is a P2X7 receptor antagonist, were added to the donor cells to investigate their effect on the transmission of the …
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The metabolism of adenosine nucleotides in thoracic muscle mitochondria from the American cockroach
… results obtained here it appears that the enzyme apyrase is not responsible for the rapid dephosphorylation of ATP. In addition, this study indicates that a specific triphosphatase coupled with myokinase produces the products AMP and P<sub>i</sub> which are found when crude homogenates are used as …
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Investigating the role of the CCL2/CCR2 axis in monocytes and its modulation by extracellular nucleotides
… and/or function. Initial observations from apyrase studies indicated an involvement of extracellular nucleotides in CCL2/CCR2-mediated monocyte signalling and function. Pharmacological experiments also indicated that although P1, P2X1, P2X4, P2X7, P2Y1, P2Y11, P2Y12, and P2Y13 purinoceptors …
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FLOW SYSTEMS FOR CLINICAL ANALYSIS USING IMMOBILIZED ENZYMES AND CHEMILUMINESCENCE DETECTION (CHROMIUM, GLUCOSE)
… for the firefly reaction when 10 mg/mL of apyrase was added to the system. The bacterial BL system exhibited much slower response than the modified firefly systems, but the bacterial system was more stable over time. Response time in the bacterial system was a function of NADH …
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Microglial Phagocytosis of Bacteria and Synapses
… LPS-induction of phagocytosis was inhibited by apyrase, or by blocking P2Y6R, indicating that LPS-induced phagocytosis is mediated by microglial P2Y6R. Moreover, exogenous ADP (which activates P2Y12R) inhibited E. coli phagocytosis by microglia, as did blocking P2Y12R, consistent with a role for …
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Structure-Activity Relationship Studies of Mitochondrial Uncouplers and PilB Inhibitors
… selectivity for PilB over an unrelated ATPase, apyrase. These compounds provide the chemical tools to validate virulence factors as antibacterial mechanisms of action.
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ΦΩΣΦΑΤΑΣΗ ΤΗΣ 1,6-ΔΙΦΩΣΦΟΡΙΚΗΣ ΦΡΟΥΚΤΟΖΗΣ ΚΑΙ ΑΤΡ-ΔΙΦΩΣΦΟΥΔΡΟΛΑΣΗ ΣΤΟΝ ΑΝΘΡΩΠΙΝΟ ΠΛΑΚΟΥΝΤΑ
FRUCTOSE 1,6-BISPHOSPHATASE (FRUCTOSE) HAS BEEN IDENTIFIED IN EXTRACTS OF HUMANTERM PLACENTA UNDER CONDITIONS WHERE THE PLACENTA WAS FROZEN IN LIQUID NITROGEN IMMEDIATELY AFTER DELIVERY . THE ENZYMATIC ACTIVITY 0.03 MMOLES FRU-P2/MIN/G TISSUE WAS FOUND TO HAVE AN ALKALINE PH OPTIMUM AND MW OF …