Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 90 for “"Approved drugs"”.
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Investigating FDA-Approved Drugs for Treatment of Multidrug-Resistant Neisseria gonorrhoeae
… is a promising approach. In this study, an FDA-approved drug library was screened, and 14 drugs were found to exhibit promising anti-gonococcal activity. Interestingly, three extremely potent and narrow-spectrum novel candidates, itraconazole, isavuconazole, and ravuconazole, are azole …
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Cell wall metabolite levels as a function of the growth phase in Staphylococcus aureus and library screening for synergistic combinations of FDA approved drugs against methicillin resistant S. aureus
… we performed a high-throughput screening of FDA-approved compounds in the presence and absence of ceftobiprole, identifying intrinsically active agents and synergistic combinations with ceftobiprole. A checkerboard analysis was then performed on potential ceftobiprole synergistic agents. Strongly …
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Drug repositioning and indication discovery using description logics
… is the discovery of new indications for approved or failed drugs. This practice is commonly done within the drug discovery process in order to adjust or expand the application line of an active molecule. Nowadays, an increasing number of computational methodologies aim at predicting …
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VERU-111 as an Oral Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer and Evaluation of Novel Tubulin Inhibitors for Cancer Therapy
… rates relative to other molecular subtypes. FDA-approved drugs, such as paclitaxel, are effective in treating TNBC. Yet, treatment failure is commonly observed due to the development of acquired chemoresistance, which remains a clinical challenge for TNBC therapy.</p>
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Insurance Design and Pharmaceutical Innovation
… United States, most patients obtain prescription drugs through insurance plans administered by Pharmacy Benefit Managers (PBMs). Beginning in 2012, PBMs began refusing to provide coverage for many newly approved drugs when cheaper alternatives were available. We show that this policy reshaped …
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Transcriptional regulation of glycosyltransferase genes in MCF-7 human breast cancer cell line following drug treatment
… large set of Food and Drug Administration (FDA) approved drugs. This is based on the understanding that aberrant glycosylation in breast cancer tumours stem from altered GT gene expression. A major goal of genomic research is the identification of genes that have been differentially expressed …
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Trajectory features as surrogate measures of the nanoparticle-microenvironment interaction space
… the delivery of strongly hydrophobic anticancer drugs, the translation of these technologies has slowed; in 1995, the ratio of animal studies to FDA-approved drugs was 19:1 and the ratio of animal studies to clinical studies was 7:1. Fifteen years later in 2010, the ratio of animal studies to …
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Identifying Protein Interactors of Voltage-Gated Sodium Channel Nav1.6 in Native Tissue
… epilepsy, neuropathic pain, and cancer. Although approved drugs targeting Nav channels are available, they lack isoform selectivity, leading to unwanted side effects. Protein-protein interactions regulate Nav channel function and represent a promising target for developing new drugs. Understanding …
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Design of a cultivation medium for protein production in Pichia pastoris based on genome-wide biological understanding
… increasing access to these life-saving drugs for large patient populations. One promising alternative host is Pichia pastoris, a methylotrophic yeast that is currently used to manufacture ten approved drugs worldwide. Its fast growth rate and ability to grow to high cell densities can …
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RNA-Seq Reveals Transcriptomic Program Associated with Stemness in Taxane Resistant Prostate Cancer
… but clinical trials have not resulted in newly approved drugs due in part to redundant survival pathways utilized by prostate tumor cells to maintain therapy-resistance. Using RNAsequencing—an innovative approach for quantifying gene expression changes—this dissertation sought to elucidate …
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Policy analysis of foreign trials needed for FDA-approved INDs for devices and drugs from 2016 to 2020
… for multinational data is more necessary for drugs in comparison to medical devices. Since drugs do not always need additional data, there is a need to investigate why medical devices are more easily approved than drugs. The use of foreign data is fairly recent, and even though there are …
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Developing methods to prioritize in vitro drug combinations against Mycobacterium tuberculosis: fusidic acid as potential combination partner with known antitubercular agents
… to augment the efficacy of current anti-TB drugs. Synergistic drug combinations present a feasible strategy towards expanding TB treatment options. Despite reported successes with combination screening, as well as the current reliance on combination therapy for TB, this approach remains …
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Pleuromutilin and its Application Towards Bidentate Antibiotics: Triazoles, Linker Chemistry, and Serendipitous Discoveries
… of veterinary antibiotics, as well as two FDA approved drugs, retapamulin and lefamulin. This class exhibits a low propensity to resistance development. This dissertation reports progress in rational design, synthesis, and testing of pleuromutilin derived antibiotics. Among these new classes of …
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Repurposing non-antimicrobial drugs to treat multi-drug resistant bacterial and fungal infections
… of clinical molecules in order to repurpose old drugs for new applications (as antimicrobials). The main aim of this research endeavor was to screen and validate approved drug libraries and small molecules for their antimicrobial activity against multidrug-resistant bacterial and fungal …
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Repurposing Oseltamivir, a Commonly Prescribed Influenza Antiviral, for the Prevention of Noise- and Cisplatin-Induced Hearing Loss
… worldwide. Yet currently, there is only one FDA-approved drug for its prevention in a subgroup of cisplatin-treated pediatric patients. Here, we performed an unbiased screen of 1,300 FDA-approved drugs for protection against cisplatin-induced cell death in an inner ear cell line, and identified …
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Identification And Rescue Of Misregulated Insulin Signaling In A Drosophila Model Of Fragile X Syndrome
… we showed that treatment with the FDA approved drug metformin also rescued memory. Finally, we showed that reduction of insulin signaling is required during the pupal period to improve circadian rhythmicity, but is not required until adulthood to rescue memory. Our results indicate that …
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Drug Repurposing for COVID-19 Using Molecular Docking Tools
… SARS-CoV-2 in wet-lab experiments, choosing drugs with similar characteristics would increase our chances of success. In this study, we compare the molecular docking results of FDA-approved drugs from the ZINC database against the molecules with positive experimental results. AutoDock Vina …
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Targeting tGLI1-positive Breast Cancer with Ketoconazole
… for multiple lesions, however, effective FDA-approved drugs for patients with intracranial progression remain an area of unmet need. Our laboratory discovered an alternative splice variant of glioma-associated oncogene homolog 1 (GLI1) in glioblastoma (GBM), termed truncated GLI1 (tGLI1), that …
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Impact of endosomal recycling inhibitors on drug resistant and immune tolerant breast cancers
… in women annually. There are a number of approved drugs on the market that have been developed or repurposed for the treatment of BC. However, a recurrent problem faced in the clinic is the emergence of drug resistance, which can be intrinsic or acquired. Prolonged periods of …
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Chemical diversification of the natural products quinine, abietic acid and pleuromutilin by ring distortion
… possess a level of molecular complexity found in approved drugs but lacking in other screening collections used in drug discovery. The chapters herein emphasize the utility of ring distortion reactions for modifying complex molecules and assert the potential of ring distortion as strategy for the …
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