Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 90 for “"Approvals"”.
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Orphan Drugs: Designations, Approvals, and Prices in the US
… Rare disease drug approvals have accelerated significantly in recent years. Even with these advances, patients continue to face challenges in receiving treatment, with most rare diseases lacking any approved treatments. Moreover, even when a treatment is available, …
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Inequality in the work visa approvals of U.S. immigrants
… economic development are less likely to receive approvals for initial and continuing employment requests, all else equal. Government agents' visa approvals may also shape career mobility among those immigrants previously granted legal standing through the evaluation of requests to change jobs or …
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Trends in U.S. regulatory approvals of the biopharmaceutical therapeutic entities
… (FDA) data, the number of new drug approvals (new molecular entities and new biologics) fell from 50 in 1996 to 29 in 2003 (FDA-BEP database 2004). Meanwhile, non-inflation adjusted expenditures for research and development have almost doubled (PhRMA 2004). This thesis uses time …
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Machine-learning models for predicting drug approvals and clinical-phase transitions
… machine-learning techniques to predict drug approvals and phase transitions using drug-development and clinical-trial data from 2003 to 2015 involving several thousand drug-indication pairs with over 140 features across 15 disease groups. Imputation methods are used to deal with missing data, …
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Approvals, Utilization, and Cost of Biologics for the Treatment of Rheumatoid Arthritis
… understanding the interplay between approvals, utilization, and cost to enhance treatment outcomes and healthcare delivery. Therefore, addressing these factors is important to ensure that all individuals with RA can benefit from these transformative therapies.</p>
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Approvals and Prices of Systemic Antibiotics in Saudi Arabia and the United States
<p><strong>Introduction</strong></p> <p>Antibiotics is one of the therapeutic classes with the highest level of consumption in the world. Despite the global diffusion of antibiotics, their availability and prices vary by country. This study assessed differences in the availability and prices of …
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Optimal planning of utility relocations and noise barrier approvals for roadway construction projects
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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The evaluation of system-wide financial incentives in pipeline decisions in the pharmaceutical and biotechnology industry : the paradox of R&D spend Vs. new drug approvals
For several decades, the ascendancy of the Pharma & Biotech sector was largely driven by favorable macro-economic conditions combined with an astonishing level of innovation and a clear focus on addressing unmet medical needs. Significant R&D investments led to innovative drugs that changed …
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The impact an accredited third party assessor will have on the regulator’s response time
… scrutiny for delays in market application (MA) approvals. The main issue that surfaces in studies related to these delays is a shortage in competent reviewers. The concept of a third party assessor (TPA) who performs pre-market approvals is introduced, one who will be providing assistance to the …
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Between plan and project : identifying gaps in plan implementation through development projects in Santa Monica and Newton
… priority sites for development lead to the approvals of those projects? To answer this question, I look at the recent planning initiatives and their associated priority development projects in two cities - Santa Monica's Land Use and Transportation Element (LUCE) and Bergamot Transit Village …
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How developers negotiate zoning and public benefits with the city : two cases in downtown Boston
… how much public benefits matter throughout the approvals process. Given the differing viewpoints between planners and developers, I hope to provide clarity on the considerations of both sides. My thesis recognizes that the negotiation between the city and developers to reach the development …
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The accelerated approval process in oncology : an examination of the conversion rate of approved therapies to full approval
… it appears that only a small fraction of these approvals (four to six) have been converted into regular approvals, based on the demonstration of clinical benefit in the post-marketing studies that support the benefit seen in the pivotal studies.
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Immigration, inequality, and the state : three essays on the employment of foreign nationals in the United States
… economic development are less likely to receive approvals for initial and continuing employment requests, all else equal. In support of social boundary theories, but not theories of preference-based inequality, I find no statistically significant differences in approval outcomes among those …
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Does Artificial Intelligence Bias Exist in Mortgage Underwriting Software? Investigating Bias, Regional Disparities, and Fair AI Models
… if there was bias in the AI mortgage application approvals. Those researchers concluded that bias does exist in the AI mortgage underwriting software. Since their study, research has demonstrated that discrimination continues to exist in AI software. Therefore, this research expands on Zou and …
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Identifying factors contributing to the delay of project timelines in public- private partnerships for housing development projects in Namibia
… (10) Town Planning/Delays in Statutory Planning Approvals; (11) Understanding of PPP implementation/Lack of understanding in PPP processes; (12) Inadequate working relationships; (13) Corruption; (14) Lack of clear PPP Policies to be managed; and, (15) No streamlined processes. According to the …
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“An Assessment of Effectiveness of Loan Appraisal Procedures and to Identify the Levels of Loan Approvals and Repayment by The Commercial Banks on the Socio Economic Status of the Population in Tanzania: A case study of CRDB Bank at Ilala District
… procedures and to identify the levels of loans approvals and repayment by the commercial Banks on the socio economic status of the population in Tanzania. The main objective was to assess effectiveness of loan appraisal procedures and to identify the levels of loans approvals and repayment by …
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Impact of the CE mark approval on exit opportunities and validation for early stage medical device companies
… of incorporation, status and dates of CE and FDA approvals, patent status, type of regulatory clearances (PMA versus 510K), type of sales models (direct versus distributorship), capitalization status and last twelve month stock returns of the acquirer was acquired. These data were then analyzed …
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Modeling correlations in clinical trial outcomes using machine learning
… and trial features. The binary nature of FDA approvals makes drug development risky, but approaches in finance theory could better manage that risk, allowing more high potential drugs to be developed. To apply these methods confidently, it is necessary to understand the covariance between …
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Risk perception of unentitled land
… given the uncertainty surrounding third party approvals. As zoning is a localized set of regulations, the process and associated risks vary from market to market.
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A Model Part-Time Bachelor's Degree Program for Adults at California Public Research Institutions
… campus and University of California systemwide approvals. These approvals are highly capital intensive and their procedures time consuming. Thus, responding to rapidly changing social and economic conditions is difficult. A survey of part-time students at a research institution provided data for …
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