Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"App/ps1"”.
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Characterising dysbiosis in Alzheimer’s disease utilising the APP/PS1 mouse model
… metabolites. In our laboratory, we utilised the APP/PS1 transgenic mouse as a model for cerebral amyloidosis in the brain. These mice overproduce β-amyloid (Aβ), allowing the study of mechanisms of neuropathology. In this project we used seven and fifteen-month mice as a representation of early …
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Modulation of Alzheimer’s Disease Pathology by Collagen-Induced Rheumatoid Arthritis in APP/PS1 Mice
… cortex and hippocampus of the double transgenic APP/PS1 mouse model for AD. Wild-type or APP/PS1 mice that received type II collagen (CII) in complete Freund’s adjuvant (CFA) at presymptomatic stage (2 months) or postsymptomatic stage (8.5 months) of age revealed characteristics of RA, such as …
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Studies on the production of IL-1β, TNF-α, iNOS, IL-10, and ROS in the APP/PS1 mouse model of Alzheimer's disease
… cerebral cortex of transgenic mouse model of AD (APP/PS1). In transgenic mice, microglia and astrocytes were activated synchronously with Aβ deposits and were abundant and closely associated with senile plaques. At 14-17 months, microglia and astrocytes were morphologically damaged and excessively …
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Implantable device for Aβ immunoselective nanopheresis in the cerebrospinal fluid to treat Alzheimer’s Disease
… de pseudoliberación IT en el modelo murino de EA APP/PS1 en fase sintomática temprana 3) Evaluar los efectos de la pseudoliberación IT a largo plazo de anticuerpos anti-Aβ mediante sustitución percutánea de la solución terapéutica en el modelo murino de EA APP/PS1 en fase sintomática temprana.
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Effect of Neurotoxic Insults in Knock Out Cell Lines for the Study of Alzheimer's Disease
… της πρόδρομης πρωτεΐνης του αμυλοειδούς (APP), της πρεσενιλίνης 1 (PS1) και της α-συνουκλεΐνης (aSyn) η οποία σχετίζεται κυρίως με τη νόσο του Parkinson’s disease (PD), δεν έχει ακόμη πλήρως αποσαφηνιστεί. Για να διερευνήσουμε τη συμβολή αυτών των πρωτεϊνών σε βασικές κυτταρικές …
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Mechanisms of Brain Region-Specific Amyloid-beta Deposition
… concentrations in several brain regions of APP transgenic mice prior to the onset of plaque deposition were proportional to the degree of subsequent plaque deposition and with the concentration of lactate, a marker of neuronal activity. Moreover, we found that physiological modulation of …
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Role of Hepatic Lipoprotein Receptor-related Protein 1 (LRP-1) on Amyloid Beta Pathology in a Mouse Model of Amyloidosis
… LRP1 was silenced specifically in the livers of APP/PS1 mice using LRP1 microRNA (miRNA) delivered by adeno-associated virus 8. (AAV8) and the hepato-specific thyroxine binding globulin (TBG) promoter, designated as AAV8.TBG.LRP1miRNA. Briefly, male APP/PS1 mice (four months at the time of …
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Glutamate Imaging of Mouse Models of Neurodegeneration
… in three mouse models of neurodegeneration: the APP-PS1 transgenic model of amyloid-beta pathology of AD, the PS19 transgenic model of tau pathology, and the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin model of PD. Glutamate levels derived from GluCEST imaging were correlated …
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The investigation of the neuronal and synaptic defects in early stage of amyloid-beta pathology
… to hypoactivity to develop therapeutic approaches for AD. We hypothesized that A accumulation may drive hyperexcitability in the early pathology because A starts deposition without tauopathy at this stage. As demonstrated in Chapter 2, our study elucidates the molecular mechanism by …
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Investigating the biological effects of (nano)particles in Alzheimer’s disease pathologies
… analytical review of the characteristics and applications of magnetite from 1990-2020, identifying the formation and broad applications in environmental, industrial, and biomedical fields, also highlighting the cytotoxic effects from overuse as a biomedicine and its potential implication in …
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THE ROLE of THE CIRCADIAN CLOCK IN DISEASE and TISSUE FUNCTION
… neuroinflammation and astrogliosis in AD model APP/PS1 mice. NOB also significantly improved glucose utilization and insulin signaling in these mice. Furthermore, I report initial evidence for a possible NOB-ROR downstream mechanism through Ephrin signaling and the NF-κB pathway. </p> <p>We also …
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Complicaciones centrales en modelos de enfermedad de alzheimer y diabetes: papel de la empagliflozina
… inducir diabetes mellitus tipo 1 (DM1) (ratón APP/PS1-STZ), un modelo de EA y prediabetes inducido por el tratamiento a largo plazo con una dieta rica en grasas (DRG) (ratón APP/PS1-DRG) y un modelo mixto de EA-DM2 (ratón APP/PS1xdb/db). Observamos una reducción general en la proliferación …
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Complicaciones centrales en un modelo murino de enfermedad de alzheimer y diabetes mellitus: papel de la liraglutida
… un modelo murino mixto de EA y DM2 (el ratón APP/PS1xdb/db). Este modelo animal permite valorar el papel de las alteraciones metabólicas en el sistema nervioso central y específicamente en la EA. Por otro lado, en la actualidad, la EA no tiene un tratamiento exitoso y por ello es necesaria la …
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Evaluation of F-18 Labeled Hydroxy Quinoline Derivative as a Potential PET Imaging Agent for Early Detection of Alzheimer’s Disease
… PET imaging agent for early detection of AD in APP/PS1 mouse model. This agent demonstrated high binding affinity to the plaque aggregates (1.5 nM), and increased fluorescence intensity upon binding to zinc. In addition, in vivo studies showed the feasibility of differentiating mice with AD from …
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Effect of anti-microbial immunizations in the progression of amyloid and neuroinflammatory pathologies in a mouse model of Alzheimer's disease
… influenza and pneumonia, were administered to APP/PS1 mice modelling brain amyloidosis characteristic of AD. Cognitive and pathological features were evaluated and compared with control mice treated with phosphate-buffered saline (PBS). As expected, immunizations and LPS administrations induced …
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The Role of TNF Signaling in Regulating Beta-Amyloid Burden in the 3xTgAD Mouse Model of Alzheimer's Disease
… mouse expressing human familial AD mutations in APP, PS1, and a familial frontotemporal dementia mutation in tau) after chronic systemic LPS exposure, we inhibited TNF signaling with novel engineered dominant negative TNF inhibitors (DN-TNF) selective for soluble TNF (solTNF) or …
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Monocytes as Gene Therapy Vectors for the Treatment of Alzheimer’s Disease
… injection. We also examined the effects of the APP+PS1 transgene on the recruitment of peripheral monocytes and showed that these cells are actively recruited to the brains in AD transgenic mouse models compared to non transgenic mice. As an approach to increase expression of NEP in a transgenic …
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Investigating the role of microglial senescence in central nervous system injury and regeneration
… this finding was not recapitulated in the APP/PS1 and AppNL-G-F amyloid mouse models, where extremely low numbers of senescent microglia were observed. To determine whether demyelination may contribute to the microglial senescence observed in the human AD tissue, I assessed microglial …
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The Association Between Traumatic Brain Injury and Alzheimer's Disease: Mouse Models and Potential Mechanisms
… Aβ and diffuse extracellular plaques occur in approximately 30% of human subjects following severe TBI. Intra-axonal accumulations of total and phospho-tau and less frequently NFTs have also been found in these patients. Due to the lack of an appropriate small animal model, it is not completely …
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Altered Expression of Metabolic Proteins Contributes to Neuropathological Disease
… from our laboratory have shown that in both the APP/PS1 and 3xTg-AD mouse models of AD, peripheral metabolic alterations exist at an early age. Specifically, 3xTg-AD mice demonstrate impaired glucose tolerance at 1 month of age associated with a decrease in insulin and insulin secretion in …