Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 116 for “"Apoptotic cell death"”.
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Characterization of apoptotic cell death in bovine red blood cells
Red blood cells (RBCs) in mammalian species display phenotypic variations in cellular functions and metabolism ascribed to their compositional and morphological differences. After accruing stress-induced damages, organelle-free human RBCs display a specialized apoptotic cell death process …
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Regulatory Architecture of Non-Apoptotic Cell Death Program in C. Elegans
<p>Cell death is prevalent in animal development, homeostasis, and disease. While apoptotic cell death has been extensively studied, many dying cells in development do not exhibit apoptotic morphology, and mice lacking core apoptotic regulators have mostly normal rates of developmental programmed …
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SHORT-CHAIN FATTY ACIDS INDUCED AUTOPHAGY SERVES AS AN ADAPTIVE STRATEGY FOR RETARDING MITOCHONDRIA-MEDIATED APOPTOTIC CELL DEATH
… and induce apoptosis in colon cancer cells, but clinical trials had mixed results regarding the anti-tumor activities of SCFAs. Herein we demonstrate that propionate and butyrate induced autophagy in human colon cancer cells to dampen apoptosis whereas inhibition of autophagy …
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Human telomerase reverse transcriptase (hTERT) overexpression modulates intracellular redox balance and protects cancer cells from apoptotic cell death
… hTERT overexpression not only reduces the basal cellular ROS levels but also inhibits endogenous ROS production in response to stimuli that induce intracellular ROS generation. Conversely, siRNA-mediated gene silencing of hTERT potentiated the increase in cellular ROS levels following exposure to …
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Characterisation of Anti-Apoptotic Signalling Pathways in Hepatocytes activated by alpha-Lipoic Acid and Atrial Natriuretic Peptide
… pathways involved in the regulation of apoptotic cell death in two different models: primary hepatocytes and ischemic isolated perfused rat livers. alpha-lipoic acid was shown to protect isolated hepatocytes from TNF-alpha-/ActinomycinD-induced apoptosis. Astonishingly, this effect did …
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CDDO-ME induces apoptosis in breast cancer cells via Ca2+ influx-mediated dilation of endoplasmic reticulum and c-FLIP downregulation
… AND METHODS 6 A.Chemicals and antibodies 6 B.Cell culture of various cancer cell lines 7 C.Measurement of cell viability 7 D.Western blotting 7 E.Immunocytochemistry 8 F.Establishment of the stable cell lines in the fluorescence specifically mitochondria or endoplasmic reticulum 9 …
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Celastrol induces paraptosis-like cell death via mitochondrial Ca2+ overload in breast cancer cells
Various cancer cells are resistant to chemotherapeutic drugs-induced apoptosis. Thus, cancer cells that have acquired resistance to apoptosis need novel strategies for inducing non-apoptotic cell death. Paraptosis is a kind of non-apoptotic cell death and characterized by extensive vacuolization …
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The Role Of ROS-mediated ERK and JNK Activation In The Induction Of Autophagy And Apoptosis In Tumour Cells By A Novel Small Molecule Compound
… reduction in tumor load is a function of apoptotic cell death, orchestrated by intracellular caspase proteases. However, the effectiveness of some of these therapies is blunted by mutations affecting specific effectors genes controlling and/or regulating apoptotic signaling. Therefore, …
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Procaspase-3 activation as a strategy to overcome resistance to targeted anticancer therapies
Apoptotic signals are tightly regulated in cells to prevent accidental or unwanted cell death. In cancer cells, however, multiple defects exist in the apoptotic machinery to evade programmed cell death. Commonly reported defects include the overexpression of anti-apoptotic proteins (e.g. Bcl-2, …
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Androgen receptor-mediated growth suppression and apoptosis of human prostate epithelial cells
… AR regulates growth suppression and survival/death of luminal epithelial cells in the prostate gland and proliferation of malignant versions of these cells are not well understood, though they are central to prostate growth, homeostasis, and neoplasia. We hypothesized that in normal adult …
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Induction And Regulation Of Autophagy By Novel Prenylation Inhibitors In Sts-26t Malignant Peripheral Nerve Sheath Tumor (mpnst) Cells
… transferase (GGTase) enzymes in many cellular and animal models of cancer. Some of these have also been evaluated in clinical trials with limited success. Multiple mechanisms of action have been elucidated for such compounds, including cell cycle arrest, proteasome inhibition, …
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The role of apoptosis in <i>in vitro</i> and <i>in vivo</i> models of amyotrophic lateral sclerosis
… disease leading to motor neurons death. Although many studies were performed, the aetiology and the features of cellular death occurring in ALS are poorly understood, and studies carried out from autoptic samples do not allow to clarify early events occurring in ALS. To understand …
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HIV-1 gp120 and Methamphetamine-mediated Induction of Proinflammatory Cytokines/chemokines and Oxidative Stress in Astrocytes: Implications in Neuroinflammation
… of MA and gp120 to produce oxidative stress and apoptotic cell death. In the first study, we investigated the role of gp120 in the cytokine production in astrocytes. SVGA astrocytes and human fetal astrocytes were either transfected with a plasmid coding gp120 or treated with recombinant gp120 …
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Biomedical applications for bacteriocins in infection and oncology
… morphological examination that nisin Z elicited apoptotic cell death in 4 colorectal cancer cell lines and potentially autophagy mediated cell death in 2 oesophageal cancer cell lines. Confocal microscopy analysis along with flow cytometry profiles further supported autophagic cell death in …
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Tnf Signaling During Tissue Damage-Induced Nociceptive Sensitization In Drosophila
… TNF/Eiger is produced from dying epidermal cells and acts its receptor in nociceptive sensory neurons to induce thermal allodynia. Inhibition of TNF signaling results in attenuation of nociceptive sensitization whereas epidermal apoptosis still occurs in the absence of TNF. Major gaps in …
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Effect of Combination of Aspirin and TRAIL in HeLa Cervical Cancer Cells
… of cytokines and induces apoptosis in most tumor cells. Although TRAIL is considered a promising drug for cancer therapies because of its tumor selectivity, many tumors are resistant to TRAIL. Thus TRAIL-resistant cancer cells must be sensitized first to become responsive to TRAIL. In this study, …
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Immunotoxic Effects of Mixtures of Endosulfan and Permethrin Via Caspase Dependent Thymocyte Apoptosis
… Actinomycin D (7AAD) to distinguish live, early apoptotic, and late apoptotic/necrotic cells. DNA ladder assay, a hallmark of apoptosis, was also used to determine the occurrence of apoptosis. Both endosulfan and permethrin were found to cause significant apoptotic death of thymocytes in a dose- …
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TAp73 regulates mitochondrial dynamics through an OPA1 axis
… to couple mitochondrial function with changing cellular demands. In this thesis, I have identified a new molecular mechanism involving TAp73/OPA1 that controls mitochondrial morphology (Buckley et al., 2020). OPA1 drives fusion of the inner mitochondrial membrane and controls cristae …
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Examining the Impact of PUFAs and the Role of Autophagy in Iron-Induced Ferroptotic Cell Death
Ferroptosis, an iron-dependent non-apoptotic cell death involves lipid peroxidation and associates with cardiometabolic disease and cancer. I established a model of iron overload in L6 cells and measured cell viability, toxicity and lipid peroxidation. Importantly, in PUFA pre-treated cells, the …
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