Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Apoptosis -- Research"”.
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Mechanisms of BAK Activation in the Initiation of Mitochondrial Apoptosis
<p>Mitochondrial apoptosis is crucial for normal mammalian development and adult homeostasis being regulated by B-Cell Lymphoma-2 (BCL-2) proteins. Deregulation of BCL-2 proteins form the basis for myriad of human pathologies including cancer and autoimmune diseases. Therefore, BCL-2 proteins are …
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The role of epigenetic changes in chemoresistant breast cancer cells
Cytotoxic chemotherapy is extremely important in adjuvant treatment of breast cancer. Yet, tumours frequently acquire chemoresistance that correlates with increased aggressiveness and poor prognosis. Three theories exist describing how the resistance develops: genetic, epigenetic and karyotypic …
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Establishing and optimizing a pipeline for using a combined multi-omic approach to assessing the role of eIF5B in glioblastoma cells
… with corresponding RNA for RNA-seq. This research will provide our lab the opportunity to expand my research on eIF5B through this pipeline as I have demonstrated that eIF5B-modulated metabolites are very cancer-relevant.