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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2349 for “"Apoptosis"”.
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Biochemical Pathways in Apoptosis
… family of proteases that once activated execute apoptosis, a cellular suicide pathway. Activated caspases have a unique property to cleave and activate themselves. Once the first caspase is activated, it generates a chain reaction resulting in robust caspase activity and rapid death. The central …
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Baculovirus inhibitors of apoptosis
A putative inhibitor of apoptosis gene was located in the Heliothis zea nucleopolyhedrovirus (HzSNPV) genome, at map units 76 to 77. Alignment of the predicted amino sequence encoded by this gene with reported inhibitor of apoptosis (iap) sequences identifted a RING finger and baculovirus IAP …
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Apoptosis in Haematopoietic progenitors
Introduction: Intracranial pressure (ICP) monitoring is a cornerstone of care for patients with severe traumatic brain injury (TBI). The primary goal of ICP treatment is to preserve brain oxygenation, and since brain oxygenation is usually not measured, the control of ICP is used as a surrogate …
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Apoptosis in retinal photoreceptor degeneration.
Apoptosis in retinal photoreceptor degeneration.
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Apoptosis Determinants in Drosophila Melanogaster
The file named "chewsu.pdf" is the primary dissertation file. All other files ("*.mov") are supplemental files and may be viewed individually.
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Genetic analysis of thymocyte apoptosis
The Glucocorticoid Receptor (GR) activates apoptosis in immature thymocytes through a mechanism that requires transactivation and repression of gene transcription. Several targets of GR regulation have been identified, including Glutathione-S-Transferase M1 (GSTM1) and Nur77 expression, and NFB …
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TRAIL mediated apoptosis in arthritis.
Apoptosis and inflammation have been considered to be linked mechanisms. Defective apoptosis may result in cell accumulation and prolonged half life of inflammatory cells in rheumatoid arthritis (RA). A similar phenomenon is seen in malignancy. Therefore, defects in apoptosis pathways that have …
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Apoptosis-induced chromatin modifications in lupus.
Contains fulltext : 82617.pdf (Publisher’s version ) (Open Access)
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STAUROSPORINE-INDUCED APOPTOSIS/PROGRAMMED CELL DEATH
Apoptosis is the mechanism by which cells are programmed to die under a wide range of physiological and developmental stimuli. Three phases of the apoptosis process, (a) induction phase, (b) commitment phase and (c) degradation phase, have been described in interphase cells only. This study …
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p38 MAPK Signalling in Endothelial Apoptosis
Endothelial apoptosis plays an important role in atherosclerosis, and a direct proapoptotic effect of chemotherapeutics on the tumour vasculature, emphasizes the great potency of antiangiogenic therapy in the treatment of cancer. We investigated signalling pathways in endothelial apoptosis induced …
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Role of Macrophage Apoptosis in Atherosclerosis.
… However, the pathogenic role of macrophage apoptosis in the development of atherosclerosis remains to be elucidated. Elevated expression of Bax, one of the pivotal pro-apoptotic proteins of the Bcl-2 family, has been found in human atherosclerotic plaques. Activation of Bax also occurs in …
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ER to Golgi transport during apoptosis
… of cisternae during interphase. However, during apoptosis the Golgi is shown to fragment and disperse throughout the cytoplasm. Immunoelectron microscopy identified these fragments as vesicular-tubular structures that contained the Golgi marker n-acetyl-glucosaminyl-transferase-1. …
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Two molecular mechanisms of apoptosis resistance
Many cancer cells develop resistance to apoptosis. It is important to understand how this phenotype develops, so that these cancers can be effectively treated. The results presented in this dissertation describe two molecular mechanisms of apoptosis resistance. A mouse keratinocyte model system …
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The E2F1-responsive microRNA-449 promotes apoptosis
Der Transkriptionsfaktor E2F1 fördert den Eintritt in den Zellzyklus, kann aber auch Apoptose induzieren, vor allem nach Aktivierung durch DNA-Schädigung. Um E2F1-responsive microRNAs zu identifizieren habe ich eine Microarray-Hybridisierung durchgeführt, und fand miR-449a und miR-449b (zusammen …
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Investigation of apoptosis by conditional gene expression
Apoptosis is a form of cell death that occurs in individual cells in normal and diseased tissues. It occurs as a consequence of activation of a program of molecular events that results in the dismantlement and clearance of cells, often without induction of an inflammatory response. Many of the …
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Rho GTPases in Neuronal Apoptosis and Neurodegeneration
… provokes neurite retraction and induces neuronal apoptosis. However, the precise signaling pathways that regulate neuronal survival downstream of Rho GTPases and the potential involvement of dysregulated activity of Rho GTPases as a causative factor in the progression of neurodegenerative diseases …
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Regulation of apoptosis and desmosomes by RhoE
… keratinocyte proliferation, differentiation, and apoptosis be precisely regulated and a failure to regulate these processes is a feature of many skin diseases. Although the precise mechanism by which epidermal homeostasis is regulated is still far from clear, much progress has been made in the …
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FOXO3a in Vascular Smooth Muscle Cell Apoptosis
… within the intimal layer. Since VSMC apoptosis plays a crucial role in the pathophysiology of atherosclerosis, we investigated the mechanisms underlying FOXO3a-mediated cell death in this particular cell type. We aimed to characterise a novel VSMC system (FOXO3aA3ERTM) and use these …
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Regulation of apoptosis in human cancer cells
… of certain kinases in nitric oxide-induced apoptosis. The experimental setup involved stimulating human colorectal cancer cells, HT-29 and HCT- 116, and human prostate cancer cells, LNCaP, with cytokines in order to induce cell death. Then, we observed the effects of NO inhibitors, kinase …
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