Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Apolipoproteins"”.
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Genetic polymorphism of the human apolipoproteins A and E
… was used to demonstrate the polymorphism of the apolipoproteins E, A-I, A-II and A-IV. Polymorphic forms of apo E were detected after ultracentrifugation of plasma, delipidation of VLDL and isoelectric focusing of the remaining protein. The six common phenotypes, homozygotes E 2/2, E 3/3, E 4/4 …
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Die altersabhängige Makuladegeneration : Untersuchung zur genetischen Assoziation des Apolipoproteins E und des Alpha-2-Makroglobulins
Die Arbeit dient der Aufklärung genetischer Ursachen der altersabhängigen Makuladegeneration (AMD) – einer komplexen Erkrankung mit bisher unklarer Ätiologie. Ziel der Arbeit war die Untersuchung einer möglichen Assoziation der AMD mit Polymorphismen in den Genen für Apolipoprotein E (ApoE) und …
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Analysis of Hepatocyte Secretion Pathways: A Case Study on Hepatic Apolipoproteins, Serum Albumin, and Hepatitis C Virus
… of the following cargoes: serum albumin, the apolipoproteins E and B100 (ApoE and ApoB100, respectively, both lipoprotein components, and surrogate markers for these complex macromolecular particles), and HCV, a lipoprotein-associated virus. I propose to combine genetic, biochemical, …
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The influence of apolipoproteins on the interaction of hepatic lipase with high density lipoproteins / Neil J. Hime
… high density lipoproteins. The results show that apolipoproteins have a major impact on these processes.
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Quasielastic light scattering studies of the formation of micelles of human apolipoproteins A-I and A-II, lecithins and bile salts
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology Program in Medical Engineering and Medical Physics, 1984.
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Apolipoprotein biosynthesis and turnover in mammalian small intestine
… liver) for the synthesis and secretion of plasma apolipoproteins, and contributes significantly to overall whole-body lipid dynamics. A prominent feature of the small intestine is its exposure to periodic loads of meals often containing dramatically varying amounts or types of food components, …
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The effect of testosterone on factors associated with diabetes, atherosclerosis and obesity.
… dysregulation in atherogenic factors such as apolipoproteins or pro-inflammatory mediators such as cytokines and chemokines and their receptors. The effect of testosterone on these factors remains unclear. The objective of the present study was to demonstrate whether testosterone has …
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tissue-specific role of ATP binding cassette transporter A1 in atherogenesis
… across the plasma membrane to combine with apolipoproteins, forming nascent high density lipoproteins (HDL), the precursor of mature plasma HDL. Mutations in ABCA1 cause Tangier disease, characterized by extremely low plasma HDL cholesterol (HDL-C) levels and widespread storage of …
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Role Of Crebh In Endotoxin Mediated Modulation Of Hepatic Metabolism
… phase response against endotoxemia by modulating apolipoproteins. Endotoxin LPS shock in the body induces activation of the TLR4 signaling pathway in mouse liver. Upon triggering TLR4 signaling pathway, LPS stimulates cleavage and activation of CREBH transcription factor LPS induces the …
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LIPID-RELATED CORONARY RISK PROFILE IN SINGAPORE NEWBORNS : RACIAL AND MOLECULAR GENETIC ASPECTS
… related to ethnicity. Plasma lipid, lipoprotein, apolipoproteins and lipoprotein(a) [Lp(a)] levels have been established as risk factors for CAD. The adult population of Singapore has shown ethnic specific plasma lipid profiles in accordance to their relative level of coronary risk. This study was …
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Factors affecting the binding of lecithin:cholesterol acyltransferase with interfacial substrates
… indicating that activation of LCAT by apolipoproteins occurs at a separate reaction step from LCAT binding.
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THE ROLE OF HEPATOCYTE ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) AND APOLIPOPROTEIN M (APOM) IN HIGH DENSITY LIPOPROTEIN (HDL) METABOLISM
… and phospholipids across the plasma membrane to apolipoproteins, forming nascent HDL particles. Hepatic ABCA1 is essential in HDL particle formation and maintenance of plasma HDL cholesterol (HDL-C) levels. However, its role in trafficking of hepatic FC into plasma versus bile for reverse …
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Hypercoiling and hydrophobically associating polymers : interfacial synthesis, surface properties and pharmaceutical applications
… such as those found in lung surfactant or plasma apolipoproteins. Stirred interfacial polymerization was used to synthesize potentially biodegradable aromatic polyamides (Mw of 12,000-26,000) based on L-Iysine, L-Iysine ethyl ester, L-ornithine and DL-diaminopropionic acid, by reaction with …
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Structure and function studies on five homogeneous reconstituted HDL complexes
… thus developed to reconstitute HDL (rHDL) from apolipoproteins and pure lipids. These rHDL have been heterogeneous in size and the number of apo A-I molecules per complex. This work shows the isolation of 5 rHDL complexes to homogeneity, and the results of studies of rHDL, apo A-I, and lipid …
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A Characterization of the Effect of Apolipoprotein AII on the Structure and Function of Apolipoprotein AI in Reconstituted High Density Lipoproteins
… by circular dichroism indicated that both apolipoproteins retained the same amount of $\alpha$-helical secondary structure as in the respective controls. Fluorescence measurements of $\lambda$max detected no change in the polarity of the Trp residues in the N-terminal half of apoAI. …
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The study of spherical high-density lipoproteins and the intermediates involved in their formation
… mainly cholesterol esters and an outer shell of apolipoproteins, phospholipids, and cholesterol. Discoidal HDL, discovered in the plasma of patients deficient in lecithin cholesterol acyltransferase (LCAT), become spherical in morphology upon incubation with LCAT and an exogenous source of …
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Understanding the Differential Effects of Dexamethasone on the Metabolism of Healthy and Diseased Articular Cartilage
… of pro-inflammatory humoral proteins and apolipoproteins that were associated with lower donor-specific Dex efficacy. Taken together, these results demonstrate the anti-catabolic effects of Dex in human cartilage and osteochondral PTOA model systems, with only minor off-target effects on …
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Lutein and α-tocopherol biodistribution in animal models
… levels of serum total and HDL cholesterol, apolipoproteins, or mRNA/protein expression of carotenoid-related genes (CD36, SCARB1, SCARB2, LDLR, STARD3, GSTP1, BCO1, BCO2, or RPE65). Dietary regimen did not impact the expression of carotenoid-related genes except for SCARB2. However, …
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IMPACT OF HEPATIC APOLIPOPROTEIN A-IV EXPRESSION ON VLDL PARTICLE EXPANSION, TRIGLYCERIDE SECRETION, AND STEATOSIS
Several apolipoproteins (apo) can impact triglyceride (TG) transport by modulating VLDL assembly and secretion. Here we explore the impact of apoA-IV on VLDL particle expansion. Previous studies demonstrated that apoA-IV expression promotes apoB lipoprotein-mediated TG secretion in transfected …
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