Global ETD Search
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Showing 1 to 20 of 37 for “"Apolipoprotein E (ApoE)"”.
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The effect of apolipoprotein E (APOE) genotype and long chain omega 3 fatty acids on body weight and inflammation
… metabolic parameters in relation to obesity. The apolipoprotein Epsilon 4 (APOE4) genotype is associated with a pro-inflammatory state, lower adiposity yet greater metabolic dysfunction in obesity and an altered LC n-3 PUFA status compared to APOE3 genotype. This PhD project aimed to investigate …
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Relationships between psychosocial stress, cortisol, apolipoprotein є4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults
… tests. Salivary cortisol levels, apolipoprotein E (APOE) genotype, and plasma beta-amyloid levels were determined at baseline.
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ApolipoproteinE-Sendai (Arg 145 ->Pro) : Expression, Reinigung und Charakterisierung einer Apolipoprotein E-Variante, die mit der Lipoprotein-Glomerulopathie assoziiert ist
Varianten des Apolipoprotein E(ApoE)sind in Zusammenhang mit der Lipoprotein-Glomerulopathie aufgetreten, einer neuen Nierenerkrankung, bei der es zur Ablagerung von Lipoproteinen in glomerulären Kapillaren kommt. Ein Drittel der betroffenen Patienten sind heterozygot für ApoE-Sendai(Arg145->Pro). …
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The Development and Application of Ultra-sensitive Protein Aggregate Detection Techniques
… aggregates. It begins by studying the role of apolipoprotein E (apoE) in amyloid- β (Aβ) pathology in Alzheimer’s disease (AD). The isoform-specific and lipidation-specific behaviours of apoE and the co-aggregates formed with A β are explored. The discussion proposes potential therapeutic …
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Association of Apolipoprotein E Genotypes with Disease Progression in Hepatitis B Virus Infected Patients
Background/aims: Apolipoprotein E (ApoE) plays an important role in regulating lipid and lipoprotein metabolism, and ApoE genotypes are known to affect plasma lipoprotein concentrations. We investigated whether ApoE genotype determine disease outcome in hepatitis B virus (HBV) infected individuals, …
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Identification and validation of target pathways influencing outcome after traumatic brain injury
… drug compounds, and dietary supplementation. The Apolipoprotein E (APOE) gene has three major alleles, APOE2, APOE3 and APOE4, the latter of which confers risk for poor outcome following TBI. Using quantitative Liquid Chromatography-Mass Spectrometry, large proteomic datasets can be generated, and …
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Phenotyping Double Transgenic Mouse Models of Alzheimer’s that Express Human APP and ApoE3 or ApoE4
… degree of neuropathology is partially related to apolipoprotein E (apoE), a fat-binding protein involved in transporting cholesterol to neurons. The APOE gene, which codes for the production of apoE, has several alleles in humans, including APOE3 (E3; the most common) and APOE4 (E4; which is …
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Apolipoprotein E alters the association of neuroinflammation with Alzheimer's disease
… a multitude of contributing genetic factors. The apolipoprotein E (APOE) allele e4 imparts a dramatic increase in the risk of developing Alzheimer’s disease, but the exact mechanism of this relationship is unknown. The e4 allele is associated with increased Ab plaques, neurofibrillary tangles, and …
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A Gain-of-Function Role of Apolipoprotein E2 in Melanoma Progression
… polymorphism of the secreted lipid transporter apolipoprotein E (APOE) plays important roles in the development of atherosclerosis and Alzheimer's disease. More recently, three common APOE alleles have been implicated as modulators of melanoma progression and survival. Melanoma patients born …
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ApoE, ApoER2, and the Regulation of Endothelial Cell Function
… disease risk is greater in individuals with the apolipoprotein E (ApoE) allele ApoE4 versus ApoE3, and this is not explained by differences in lipid profiles. A point mutant of the ApoE receptor ApoER2, ApoER2-R952Q, is also associated with greater cardiovascular disease risk, suggesting a role …
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Regulatory Role of ApoE and Apoer2 in Synaptic Activity: A New Insight into Alzheimer's Disease
Apolipoprotein E (ApoE) genotype is the major genetic modifier of late-onset Alzheimer's disease (AD), the most common neurodegenerative disease in the elderly. By unknown mechanisms, ApoE4 isoform is strongly associated with a substantially earlier age of onset of AD. A synaptic ApoE receptor, …
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Assoziationen zwischen Polymorphismen lithogener Kandidatengene und Risikofaktoren der Cholesterincholelithiasis
… established human candidate genes like the apolipoprotein E (APOE) and the cholesteryl ester transfer protein (CETP) were included in the study.Suitable single nucleotide polymorphisms (SNPs) were identified by database searches (NCBI genbank, JSNP database, HGV base), based on genomic …
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The Role of Apolipoprotein E in Pregnancy-Associated Protein Misfolding and Risk of Preeclampsia
… misfolding manifesting as preeclampsia and Apolipoprotein E (APOE), a polymorphic gene with well-established roles in β-amyloid deposition in the brain. In humans, APOE has three naturally occurring alleles: APOE3 the non-pathogenic allele; APOE2, which is protective against AD; and APOE4, …
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The Advancement of Mass Spectrometry-based Hydroxyl Radical Protein Footprinting: Application of Novel Analysis Methods to Model Proteins and Apolipoprotein E
… the oligomeric structures of three human apolipoprotein E: ApoE) isoforms and a monomeric mutant in their lipid-free states. Only one isoform of ApoE is strongly associated with Alzheimer's disease; unfortunately, the structural reason for this association is not known, in part because no …
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Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism
… exists that both the isoform and amount of apolipoprotein E (apoE), an amyloid beta-binding molecule, influence amyloid beta aggregation and clearance from the brain. Therefore, studying how the molecular mechanisms that modulate apoE levels in the brain affect amyloid beta clearance will …
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An Insight into Alpha-Synulcien's Biological Function and Its Pathogenesis in Neurodegenerative Disease
… beta -peptides. Protein quantification of apolipoprotein E (ApoE) a protein that has been associated with the development of Alzheimer's disease, demonstrated a 5-15 fold increase in symptomatic transgenic mice. Ablation of ApoE in alpha -synuclein transgenic mice by genetic crosses …
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The Impact of Lipid Nanoparticle Chemistry on RNA Delivery and Therapeutic Outcomes
… corona analysis indicated that 5A2-SC8 LNPs bind Apolipoprotein E (ApoE), which can drive LDL-R receptor mediated endocytosis in hepatocytes. In contrast, the surface of 3A5-SC14 LNPs was enriched in Albumin but depleted in ApoE, which likely led to Kupffer cell delivery and detargeting of …
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AB affects apoE transcriptionally through the activation of B-AR, cAMP and AP-2
… disease (AD) are amyloid beta protein (Aβ) and apolipoprotein E (apoE). We and others have reported that Aβ elevates apoE protein levels in astrocytes, which in turn could alter lipid trafficking and cell function. The mechanism for the Aβ-induced increase in apoE levels is not clearly …
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The APOE Pathway as a Modulator of Amyloid Pathology in Alzheimer's Disease Models
… (Aβ) peptides and amyloid plaque deposition. The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for sporadic AD, with apoE protein crucial for brain lipid transport. ATP-binding cassette subfamily A member 1 (ABCA1), another risk gene, loads lipids onto apoE, highlighting …
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Neurocognitive disorders in young adults commencing highly active antiretroviral treatment in the Western Cape
… assessments. Laboratory investigations included apolipoprotein E (APOE) genotyping. The performance of the International HIV Dementia Scale (IHDS) as a brief screening tool was analysed using a receiver operating characteristic (ROC). At one-year, 105 participants were re-assessed for …
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