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Showing 1 to 20 of 34 for “"Apolipoprotein E (ApoE)"”.
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The effect of apolipoprotein E (APOE) genotype and long chain omega 3 fatty acids on body weight and inflammation
… metabolic parameters in relation to obesity. The apolipoprotein Epsilon 4 (APOE4) genotype is associated with a pro-inflammatory state, lower adiposity yet greater metabolic dysfunction in obesity and an altered LC n-3 PUFA status compared to APOE3 genotype. This PhD project aimed to investigate …
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Relationships between psychosocial stress, cortisol, apolipoprotein є4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults
… tests. Salivary cortisol levels, apolipoprotein E (APOE) genotype, and plasma beta-amyloid levels were determined at baseline.
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ApolipoproteinE-Sendai (Arg 145 ->Pro) : Expression, Reinigung und Charakterisierung einer Apolipoprotein E-Variante, die mit der Lipoprotein-Glomerulopathie assoziiert ist
Varianten des Apolipoprotein E(ApoE)sind in Zusammenhang mit der Lipoprotein-Glomerulopathie aufgetreten, einer neuen Nierenerkrankung, bei der es zur Ablagerung von Lipoproteinen in glomerulären Kapillaren kommt. Ein Drittel der betroffenen Patienten sind heterozygot für ApoE-Sendai(Arg145->Pro). …
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The Development and Application of Ultra-sensitive Protein Aggregate Detection Techniques
… aggregates. It begins by studying the role of apolipoprotein E (apoE) in amyloid- β (Aβ) pathology in Alzheimer’s disease (AD). The isoform-specific and lipidation-specific behaviours of apoE and the co-aggregates formed with A β are explored. The discussion proposes potential therapeutic …
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Association of Apolipoprotein E Genotypes with Disease Progression in Hepatitis B Virus Infected Patients
Background/aims: Apolipoprotein E (ApoE) plays an important role in regulating lipid and lipoprotein metabolism, and ApoE genotypes are known to affect plasma lipoprotein concentrations. We investigated whether ApoE genotype determine disease outcome in hepatitis B virus (HBV) infected individuals, …
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Identification and validation of target pathways influencing outcome after traumatic brain injury
… drug compounds, and dietary supplementation. The Apolipoprotein E (APOE) gene has three major alleles, APOE2, APOE3 and APOE4, the latter of which confers risk for poor outcome following TBI. Using quantitative Liquid Chromatography-Mass Spectrometry, large proteomic datasets can be generated, and …
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Phenotyping Double Transgenic Mouse Models of Alzheimer’s that Express Human APP and ApoE3 or ApoE4
… degree of neuropathology is partially related to apolipoprotein E (apoE), a fat-binding protein involved in transporting cholesterol to neurons. The APOE gene, which codes for the production of apoE, has several alleles in humans, including APOE3 (E3; the most common) and APOE4 (E4; which is …
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Apolipoprotein E alters the association of neuroinflammation with Alzheimer's disease
… a multitude of contributing genetic factors. The apolipoprotein E (APOE) allele e4 imparts a dramatic increase in the risk of developing Alzheimer’s disease, but the exact mechanism of this relationship is unknown. The e4 allele is associated with increased Ab plaques, neurofibrillary tangles, and …
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ApoE, ApoER2, and the Regulation of Endothelial Cell Function
… disease risk is greater in individuals with the apolipoprotein E (ApoE) allele ApoE4 versus ApoE3, and this is not explained by differences in lipid profiles. A point mutant of the ApoE receptor ApoER2, ApoER2-R952Q, is also associated with greater cardiovascular disease risk, suggesting a role …
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Regulatory Role of ApoE and Apoer2 in Synaptic Activity: A New Insight into Alzheimer's Disease
Apolipoprotein E (ApoE) genotype is the major genetic modifier of late-onset Alzheimer's disease (AD), the most common neurodegenerative disease in the elderly. By unknown mechanisms, ApoE4 isoform is strongly associated with a substantially earlier age of onset of AD. A synaptic ApoE receptor, …
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A Gain-of-Function Role of Apolipoprotein E2 in Melanoma Progression
… polymorphism of the secreted lipid transporter apolipoprotein E (APOE) plays important roles in the development of atherosclerosis and Alzheimer's disease. More recently, three common APOE alleles have been implicated as modulators of melanoma progression and survival. Melanoma patients born …
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The Role of Apolipoprotein E in Pregnancy-Associated Protein Misfolding and Risk of Preeclampsia
… misfolding manifesting as preeclampsia and Apolipoprotein E (APOE), a polymorphic gene with well-established roles in β-amyloid deposition in the brain. In humans, APOE has three naturally occurring alleles: APOE3 the non-pathogenic allele; APOE2, which is protective against AD; and APOE4, …
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The Advancement of Mass Spectrometry-based Hydroxyl Radical Protein Footprinting: Application of Novel Analysis Methods to Model Proteins and Apolipoprotein E
… the oligomeric structures of three human apolipoprotein E: ApoE) isoforms and a monomeric mutant in their lipid-free states. Only one isoform of ApoE is strongly associated with Alzheimer's disease; unfortunately, the structural reason for this association is not known, in part because no …
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Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism
… exists that both the isoform and amount of apolipoprotein E (apoE), an amyloid beta-binding molecule, influence amyloid beta aggregation and clearance from the brain. Therefore, studying how the molecular mechanisms that modulate apoE levels in the brain affect amyloid beta clearance will …
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An Insight into Alpha-Synulcien's Biological Function and Its Pathogenesis in Neurodegenerative Disease
… beta -peptides. Protein quantification of apolipoprotein E (ApoE) a protein that has been associated with the development of Alzheimer's disease, demonstrated a 5-15 fold increase in symptomatic transgenic mice. Ablation of ApoE in alpha -synuclein transgenic mice by genetic crosses …
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The Impact of Lipid Nanoparticle Chemistry on RNA Delivery and Therapeutic Outcomes
… corona analysis indicated that 5A2-SC8 LNPs bind Apolipoprotein E (ApoE), which can drive LDL-R receptor mediated endocytosis in hepatocytes. In contrast, the surface of 3A5-SC14 LNPs was enriched in Albumin but depleted in ApoE, which likely led to Kupffer cell delivery and detargeting of …
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AB affects apoE transcriptionally through the activation of B-AR, cAMP and AP-2
… disease (AD) are amyloid beta protein (Aβ) and apolipoprotein E (apoE). We and others have reported that Aβ elevates apoE protein levels in astrocytes, which in turn could alter lipid trafficking and cell function. The mechanism for the Aβ-induced increase in apoE levels is not clearly …
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The APOE Pathway as a Modulator of Amyloid Pathology in Alzheimer's Disease Models
… (Aβ) peptides and amyloid plaque deposition. The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for sporadic AD, with apoE protein crucial for brain lipid transport. ATP-binding cassette subfamily A member 1 (ABCA1), another risk gene, loads lipids onto apoE, highlighting …
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Neurocognitive disorders in young adults commencing highly active antiretroviral treatment in the Western Cape
… assessments. Laboratory investigations included apolipoprotein E (APOE) genotyping. The performance of the International HIV Dementia Scale (IHDS) as a brief screening tool was analysed using a receiver operating characteristic (ROC). At one-year, 105 participants were re-assessed for …
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Germline Genetic Determination of Cancer Outcome
… impact of three highly prevalent variants of the Apolipoprotein E (APOE) gene on melanoma progression and outcome. Using transgenic human APOE mice, we found that mice expressing the APOE4 variant exhibit slower melanoma progression and metastasis than APOE2 mice. The impact of APOE genotype on …
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