Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 92 for “"Apolipoprotein E"”.
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The Effects of Apolipoprotein E on Amyloid-beta Induced Neurodegeneration.
The Effects of Apolipoprotein E on Amyloid-beta Induced Neurodegeneration.
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Apolipoprotein E and propagation of pathological tau in Alzheimer’s Disease
… to AD pathogenesis and is mediated by glia. Apolipoprotein E (APOE) genotype is the strongest genetic risk factor for the late-onset AD, with APOE4 increasing risk and APOE2 conferring protection. The exact mechanisms by which APOE modulates AD risk remain to be comprehensively discerned. …
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Apolipoprotein E alters the association of neuroinflammation with Alzheimer's disease
… a multitude of contributing genetic factors. The apolipoprotein E (APOE) allele e4 imparts a dramatic increase in the risk of developing Alzheimer’s disease, but the exact mechanism of this relationship is unknown. The e4 allele is associated with increased Ab plaques, neurofibrillary tangles, and …
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Apolipoprotein E genotypes and Alzheimer disease in two black population groups
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Apolipoprotein E Activation and Phosphatidylcholine Substrate Requirements of Lecithin Cholesterol Acyl Transferase
The apolipoprotein activation of lecithin cholesterol acyl transferase (LCAT) by human apolipoprotein E (apo E) was investigated by incorporating apo E into discoidal complexes of egg phosphatidylcholine (egg-PC) and cholesterol by the cholate dialysis method. These complexes were systematically …
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Metabolism of omega-3 fatty acids in carriers of apolipoprotein E epsilon 4
… 60 to 70% of those cases. Carrying the apolipoprotein E epsilon 4 allele (APOE4) is the main genetic risk factor for late onset Alzheimer’s disease. Studies have found that consuming a diet rich in omega-3 fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) can …
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Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism
… exists that both the isoform and amount of apolipoprotein E (apoE), an amyloid beta-binding molecule, influence amyloid beta aggregation and clearance from the brain. Therefore, studying how the molecular mechanisms that modulate apoE levels in the brain affect amyloid beta clearance will …
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The Role of Apolipoprotein E in Pregnancy-Associated Protein Misfolding and Risk of Preeclampsia
… misfolding manifesting as preeclampsia and Apolipoprotein E (APOE), a polymorphic gene with well-established roles in β-amyloid deposition in the brain. In humans, APOE has three naturally occurring alleles: APOE3 the non-pathogenic allele; APOE2, which is protective against AD; and APOE4, …
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The Role of Apolipoprotein E Concentration and Isoform in Amyloid-beta Metabolism In Vivo
Alzheimer's disease is a progressive, neurodegenerative disease characterized by several pathological lesions, one of which is the accumulation of the amyloid-β: Aβ) peptide into extracellular amyloid plaques. Several autosomal dominant mutations have been shown to cause familial forms of …
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Association of Apolipoprotein E Genotypes with Disease Progression in Hepatitis B Virus Infected Patients
Background/aims: Apolipoprotein E (ApoE) plays an important role in regulating lipid and lipoprotein metabolism, and ApoE genotypes are known to affect plasma lipoprotein concentrations. We investigated whether ApoE genotype determine disease outcome in hepatitis B virus (HBV) infected individuals, …
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The associations between plasma homocysteine, vitamin B12, folate, the Apolipoprotein E genotype and Alzheimer's Disease
… of AD include age, the presence of the Apolipoprotein ε4 allele, low vitamin B₁₂ and folate levels, and elevated plasma homocysteine concentrations. Most research involving the associations between these risk factors and AD have been conducted in Europe and North America. We know little …
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The Interactions Among Estrogen, Apolipoprotein E and Amyloid-beta in the EFAD Mouse Model of AD.
The Interactions Among Estrogen, Apolipoprotein E and Amyloid-beta in the EFAD Mouse Model of AD.
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Polimorfisme gen apolipoprotein E pada pasien infark miokard akut (IMA) di Rumah Sakit dr. Saiful Anwar Malang
INDONESIA: Apolipoprotein E (Apo E) memiliki peran yang penting dalam metabolisme lipid dalam plasma. Kadar lipid sangat dipengaruhi oleh polimorfisme gen Apo E. Apo E terdiri dari tiga macam alel, yaitu ε2, ε3, and ε4 yang membentuk 6 genotip E2/E2, E3/E3, E4/E4, E4/E2, E4/E3, dan E3/E2. Sehingga …
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Neural stem cell grafts and the influence of apolipoprotein E in a mouse model of global ischaemia
… ischaemia model, the lipid transport protein apolipoprotein E (apoE) is upregulated and co-localised to differentiated cells in parallel with functional recovery. ApoE has been shown to have a critical role in the response to brain injury and repair processes. Furthermore, in humans, three …
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