Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"ApoER2"”.
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ApoE, ApoER2, and the Regulation of Endothelial Cell Function
… profiles. A point mutant of the ApoE receptor ApoER2, ApoER2-R952Q, is also associated with greater cardiovascular disease risk, suggesting a role for ApoER2 in vascular health and disease. However, how ApoE, ApoER2, and their variants influence cardiovascular health and disease is poorly …
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Regulation and Function of Apoer2 and Vidlr in the Central Nervous and Reproductive Systems
… of organismal functions. Members of this family, Apoer2 and Vldlr, are highly similar receptors and are both involved in the Reelin signaling pathway. This pathway controls neuronal migration and organization of the brain during development as well as synaptic function in adulthood. Although both …
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Regulatory Role of ApoE and Apoer2 in Synaptic Activity: A New Insight into Alzheimer's Disease
… age of onset of AD. A synaptic ApoE receptor, Apoer2, activates Dab1 and Src family tyrosine kinases (SFKs) upon binding to the extracellular ligand Reelin. Here, we show that this Reelin-Apoer2-Dab1-SFKs signaling complex greatly enhances the tyrosine phosphorylation as well as the calcium …
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Expression of Apolipoprotein E Receptor 2 (ApoER2) and Very Low Density Lipoprotein Receptor (VLDLR), Reelin Receptors in Development of Cerebellar Cortex
… Reelin binds to apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) that are members of lipoprotein receptor family, and induces the tyrosine phosphorylation of disabled1 (Dab1), an adaptor protein binding to cytoplasmic domain of reelin receptors. Mice …
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Vergleichende Untersuchung des Reelinsignalweges bei Wildtyp- und Presenilin-1-Knockoutmäusen während der embryonalen Hirnentwicklung
… von den reelinabhängigen Rezeptoren VLDLR und ApoER2 dargestellt. Dafür wurde die Technik der in situ Hybridisierung für die unterschiedlichen Sonden (reelin, dab1, VLDLR, ApoER2) an embryonalen Gehirnschnitten angewendet. <br>Die Ergebnisse zeigen, dass es in PS-1-Knockoutmäusen im Vergleich …
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Role of Reelin-Dab1 Signaling in the Neuritogenesis
… (VLDLR) and apolipoprotein E receptor 2 (ApoER2), inducing tyrosine phosphorylation of Dab1, a cytoplasmic adaptor protein of receptors. The Reelin-Dab1 signaling is regulatory key to migration and positioning of neuronal cell during brain development. It also reported that …
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A novel in vivo protein refolding technique
… domain of apolipoprotein E receptor 2 (LBD-ApoER2). These two proteins contain a large number of cysteines that form intracellular disulfide bonds. The folding of these two proteins is very challenging. I performed optimizations of experimental conditions that allow me to produce large …
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Dissecting the Molecular Basis of the Antiphospholipid Syndrome
… vascular conductance studies is absent in apoER2 -/- mice. Thus, aPL-induced changes in endothelial cell phenotype are mediated by eNOS antagonism, which is due to impaired Ser1179 phosphorylation and requires beta 2GPI and apoER2. eNOS antagonism through these mechanisms represent a novel, …
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Die Körnerzellposition beeinflusst die Faserschichtung der Fascia dentata der Maus : eine Studie an Reeler, Apolipoprotein E Receptor 2 defizienten und Very Low Density Lipoprotein Receptor defizienten Mäusen
… ist in vldlr -/- Mäusen leicht verändert, in apoER2 -/- Mäusen stark gestört und in rl -/- Mäusen aufgehoben. Die Veränderungen der Körnerzellanordnung spiegeln sich im Terminationsmuster kommissuraler Fasern wider. Während diese Fasern im Kontrolltier geschichtet enden, finden sie sich in den …