Global ETD Search
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Showing 1 to 20 of 37 for “"ApoE4"”.
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Phenotyping Double Transgenic Mouse Models of Alzheimer’s that Express Human APP and ApoE3 or ApoE4
… including APOE3 (E3; the most common) and APOE4 (E4; which is associated with a high risk for developing AD). Transgenic mouse models of AD are commonly used to study the neuropathological processes behind the development of Aβ plaques, neurodegeneration, and associated behavioral deficits. …
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ApoE4 Genotype as a Moderator of Brain Responses to Target Stimuli Prior and Subsequent to Smoking Abstinence
A growing body of research is targeted towards characterizing and explaining nicotine’s complex interactions with the ApoE E4 allele on brain responses underlying cognitive processes. However, when and how the ε4 allele modulates neuroelectric brain responses in the presence of nicotine versus …
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A Gain-of-Function Role of Apolipoprotein E2 in Melanoma Progression
… Melanoma patients born with a copy of the APOE4 allele exhibit improved disease survival and responses to immunotherapy. Conversely, APOE2 allele carriers experience substantially worsened survival outcomes compared to APOE4 carriers and APOE3 homozygotes. These survival differences are …
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Long-Term Memory Biases Auditory Spatial Attention: Healthy and Impaired “Memory-Guided Attention”
… on this task is related to Apolipoprotien E4 (APOE4) genotype, a risk factor for the sporadic AD (Study 3). During an initial familiarization task, participants heard audio-clips some of which included a lateralized target (p = 50%). On each trial, participants indicated whether the target was …
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Regulatory Role of ApoE and Apoer2 in Synaptic Activity: A New Insight into Alzheimer's Disease
… disease in the elderly. By unknown mechanisms, ApoE4 isoform is strongly associated with a substantially earlier age of onset of AD. A synaptic ApoE receptor, Apoer2, activates Dab1 and Src family tyrosine kinases (SFKs) upon binding to the extracellular ligand Reelin. Here, we show that this …
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The effect of apolipoprotein E (APOE) genotype and long chain omega 3 fatty acids on body weight and inflammation
… to obesity. The apolipoprotein Epsilon 4 (APOE4) genotype is associated with a pro-inflammatory state, lower adiposity yet greater metabolic dysfunction in obesity and an altered LC n-3 PUFA status compared to APOE3 genotype. This PhD project aimed to investigate the relationships between …
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Metabolism of omega-3 fatty acids in carriers of apolipoprotein E epsilon 4
… Carrying the apolipoprotein E epsilon 4 allele (APOE4) is the main genetic risk factor for late onset Alzheimer’s disease. Studies have found that consuming a diet rich in omega-3 fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) can decrease the risk of developing …
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Apolipoprotein E4 and SirT1 Interaction in Alzheimer’s Disease
… Εpsilon 4, an allele of apolipoprotein E (ApoE4), is currently the most important risk factor for Alzheimer’s disease. Individuals that inherit two copies of the ApoE ε4 allele have an approximately ten to thirty times increased risk of developing AD in comparison to persons not carrying …
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The role of complement FH and apoE interactions in the regulation of Aβ1-42 and C1q-mediated complement activation
The APOE4 gene variant of apolipoprotein E (apoE) has been identified as a predisposing factor for late-onset Alzheimer’s disease (AD). ApoE is known to interact with one of the classically characterized hallmarks of AD, the amyloid-beta (Aβ) protein. Aβ activates the classical complement pathway …
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Apolipoprotein E and propagation of pathological tau in Alzheimer’s Disease
… genetic risk factor for the late-onset AD, with APOE4 increasing risk and APOE2 conferring protection. The exact mechanisms by which APOE modulates AD risk remain to be comprehensively discerned. APOE influences Ab pathology, but distinct roles in neurodegeneration and Ab-independent mechanisms …
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ApoE, ApoER2, and the Regulation of Endothelial Cell Function
… with the apolipoprotein E (ApoE) allele ApoE4 versus ApoE3, and this is not explained by differences in lipid profiles. A point mutant of the ApoE receptor ApoER2, ApoER2-R952Q, is also associated with greater cardiovascular disease risk, suggesting a role for ApoER2 in vascular health …
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ApoE2-Mediated Neuroprotection Against Alzheimer’s Disease: from Mechanism to Translation
… the neuroprotective role of ApoE2 in ApoE4 models and explored the underlying mechanisms by which ApoE isoforms differentially regulate glycolysis.In the first chapter, ApoE2 neuron-like cells were found to exhibit significantly enhanced glycolytic function through upregulation of …
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The Role of Apolipoprotein E in Pregnancy-Associated Protein Misfolding and Risk of Preeclampsia
… APOE2, which is protective against AD; and APOE4, which increases the risk of AD up to 15-fold. In a well-characterized cohort of mother-newborn dyads, we demonstrate that fetal APOE4 genotype and female sex increase the risk of preeclampsia manifesting with fetal growth restriction (FGR). …
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Germline Genetic Determination of Cancer Outcome
… APOE mice, we found that mice expressing the APOE4 variant exhibit slower melanoma progression and metastasis than APOE2 mice. The impact of APOE genotype on melanoma progression was mediated by modulation of anti-melanoma immunity. APOE4 mice showed enhanced activation of anti-tumor immunity …
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Identification and validation of target pathways influencing outcome after traumatic brain injury
… gene has three major alleles, APOE2, APOE3 and APOE4, the latter of which confers risk for poor outcome following TBI. Using quantitative Liquid Chromatography-Mass Spectrometry, large proteomic datasets can be generated, and the difference in protein expression in response to TBI between …
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Risk Factors for Postoperative Cognitive Dysfunction in Older Adults Undergoing Major Noncardiac Surgery
… and patients who had the apolipoprotein-E4 (ApoE4) allele, as potential inflammatory and genetic biomarkers for POCD, respectively. A nonsurgical control group, that is similar to patients in age, education level, and computer familiarity, was recruited to adjust for learning effects from …
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ApoE Receptors in Alzheimer's and CNS Function
… for AD is the ε4 allele of apolipoprotein E (ApoE4). Other genes related to lipid metabolism and lipoprotein receptor signaling have also been identified as risk modifiers for AD. Despite nearly two decades of research, the mechanisms by which lipid transport proteins cause central nervous …
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ROLE OF LECITHIN:CHOLESTEROL ACYLTRANSFERASE (LCAT) IN BRAIN CHOLESTEROL METABOLISM AND ITS INVOLVEMENT IN ALZHEIMER¿S DISEASE
… In the brain apoE is the main LCAT cofactor, and apoE4, one of the three apoE isoforms, is the strongest known genetic risk factor for Alzheimer’s disease (AD), but its ability in activation of LCAT enzyme has never been investigated. Moreover, several epidemiological studies indicate a strong …
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Axonal Damage in Repetitive Concussive Traumatic Brain Injury: Characterization and Contributing Factors
… and APP<sub>SWE</sub>). The Apolipoprotein E4 (APOE4) genotype is a risk factor for poor outcome following traumatic brain injury, especially in young patients. By analogy to APOE4's effects on the risk of Alzheimer's disease, one hypothesis is that APOE genotype influences amyloid-beta …
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Influence of ApoE polymorphism on synaptic morphometry during aging in the dentate gyrus of ApoE knockout and human ApoE transgenic mice
… of human Apolipoprotein E (ApoE2, ApoE3 and ApoE4), the ?4 allele coding for ApoE4 is associated with a higher risk of developing Alzheimer's disease (AD) and an earlier age of onset, whereas ?2 may be protective. The mechanisms underlying such influences are still unclear. This thesis has …
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