NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 42 for “"ApoB"”.

  1. In-vivo Metabolismus der VLDL-Apolipoproteine ApoB, ApoCIII und ApoE

    Dinkel, Regina ElkeLudwig-Maximilians-Universität

    … den Stoffwechsel der VLDLApolipoproteine ApoB, ApoCIII und ApoE bei 6 normolipämischen und einem hypertriglyceridämischen Probanden mit einer endogenen nicht-radioaktiven Tracermethode. Als Tracer wurde mit D3 markiertes Leucin eingesetzt. Nach Abtrennung der verschiedenen …

    lmu-germany Repository record

  2. The New Role of Proprotein Convertase Subtilisin/Kexin Type 9: A Connection of Proprotein Convertase Subtilisin/Kexin Type 9, Apolipoprotein B, and Autophagy

    Sun, Hua2012

    … observed PCSK9 interacted with apolipoprotein B (apoB) and increased apoB production, irrespective of the LDLR.</p> <p>ApoB is the primary structure protein of LDL particle and it also serves as the ligand for the LDL receptor. There is ample evidence showing that the levels of apoB are a better …

    uthsc Repository record

  3. THE USE OF REPLICATION-DEFECTIVE ADENOVIRAL VECTORS FOR EXPRESSION OF PRIMORDIAL ATHEROGENIC LIPOPROTEINS IN MICE

    Graves, Jason T.Wake Forest University2011

    The plasma concentration of apolipoprotein B (apoB)-containing lipoproteins is positively associated with several diseases, including atherosclerosis, type 2 diabetes and obesity. Hence, apoB may be a prime target for therapeutic intervention, particularly during its assembly. The molecular events …

    wfu Repository record

  4. Mechanisms behind the lipid-lowering effects of ACTH - Studies in different experimental models

    Skoog, MariaMaria Skoog dept. of Laboratory Medicine Lund University2007

    … and direct lipid-lowering effects in man. All apoB-containing lipoproteins, i.e. VLDL, LDL, Lp(a), are reduced by 25-30%. In contrast, levels of HDL increase about 10%. In hepatic cell cultures, ACTH inhibits expression and secretion of apoB. In this thesis we corroborate that the reduced apoB …

    lund Repository record

  5. The molecular and cellular defect underlying autosomal recessive hypercholesterolemia (ARH) in the first kindred identified in South Africa

    Abera, AronDepartment of Medicine2005

    … in LDLr binding domain of apolipopreteinB-100 (apoB-100) are rarely encountered and are know as Familial defective apoB-100 (FDB). Several critical proteins are active in the LDL uptake pathway and their deficiencies are now being shown to underlie the rare autosomal recessive forms of …

    cape-town Repository record

  6. Impatto del profilo lipidico sulla malattia aterosclerotica in due differenti coorti di pazienti ad alto rischio cardiovascolare

    SCICALI, ROBERTOUniversità degli studi di Catania2021

    … in the pathogenesis of atherosclerosis. Of note, ApoB-lipoproteins up to only approximately 70 nm in diameter [i.e., chylomicron remnants, smaller very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), LDL, and lipoprotein(a)] can efficiently cross an intact endothelium, …

    catania Repository record

  7. IMPACT OF HEPATIC APOLIPOPROTEIN A-IV EXPRESSION ON VLDL PARTICLE EXPANSION, TRIGLYCERIDE SECRETION, AND STEATOSIS

    VerHague, MelissaWake Forest University2013

    … demonstrated that apoA-IV expression promotes apoB lipoprotein-mediated TG secretion in transfected enterocytes and hepatoma cells. We therefore examined the impact of apoA-IV expression on VLDL particle dynamics in stably transfected McA-RH7777 hepatoma cells. Expression of apoA-IV caused an …

    wfu Repository record

  8. Identification and Characterization of APOBEC1 mRNA Editing Targets: A Transcriptomics Approach

    Rosenberg, Brad Randall

    … B mRNA Editing Catalytic polypeptide 1 (APOBEC1) cytidine deaminase is an mRNA editing enzyme that modifies a specific cytidine in the apolipoprotein B (apoB) transcripts of small intestine enterocytes. APOBEC1-mediated cytidine to uridine editing generates an inframe stop codon and …

    rockefeller Repository record

  9. Caracterización bioquímica y genómica de las respuestas inducidas por lípidos de la dieta durante el desarrollo larvario del lenguado senegalés (Solea senegalensis, Kaup 1858)

    Román Padilla, Javier2018

    … para la apoA-IV, tres parálogos para la apoB, la apoC-I, la apoC-II, dos parálogos para la apoE, cinco parálogos para la apoD y la apo14 en lenguado senegalés. El estudio de sintenia de las apoA, apoC, y apoE ha permitido confirmar que la mayoría de estos genes (excepto la apoA-I) se …

    cadiz Repository record

  10. Development of a Passive Immunization Strategy Against Atherosclerosis

    Schiopu, AlexandruDepartment of Clinical Sciences, Lund University2006

    … are aldehyde-modified peptide sequences of apoB-100, the main protein in LDL structure. Immunization of atherosclerosis-prone mice with some of the apoB-100 peptides reduced plaque area by up to 60% in the immunized mice compared to controls. We tested the effects of recombinant human IgG1 …

    lund Repository record

  11. Chemische Modifikation von siRNAs zur Verbesserung der zellulären Aufnahme

    Forst, AndreaUniversität Bayreuth

    … die posttranskriptionelle Hemmung der apoB Genexpression in Leberparenchymzellen ermöglichen. Ein erster Ansatz zielte auf die Erhöhung der Hydrophobizität der siRNAs und eine damit verbundene Erleichterung der zellulären Annäherung. Als Grundbausteine dienten Lithocholsäure, …

    bayreuth Repository record

  12. Analyse der Low-Density-Lipoproteine (LDL) : kann die LFE die UZ-Fraktionierung von LDL ersetzen?

    Knothe, Ingrid

    … dienten dabei die fraktionsweise gemessenen ApoB- und Chol-Werte. Bei 28 Seren ergab sich in den UZ-Subfraktionen keine Hauptfraktion, sondern eine annähernde Gleichverteilung der Messparameter. Eine Zuordnung entfiel daher für diese Seren. Als UZ-Hauptfraktion wurden dann nur solche Proben …

    freiburg-diss Repository record

  13. The effects of moderate exercise on measures of postprandial lipemia

    Cox-York, Kimberly Ann, author, Horton, Tracy J., advisor, Pagliassotti, Michael, advisorColorado State University. Libraries2009

    … had no effect on PPTG. With exercise, total apoB IAUC decreased 20% in the whole group, and total cholesterol IAUC decreased 30% in the NW group. MetS subjects maintained significantly higher TG than NW subjects over the day (p<0.001). PPTG in MetS women declined mid-day, and remained low for …

    colostate Repository record

  14. Effects of Vitamin E Supplementation in Late Gestation Cattle and Evaluation of Vitamin E, Cholesterol, and Phospholipid Relationships in Bovine Serum and Serum Lipoproteins

    Bass, Roger Thompson IIVirginia Tech1999

    … fraction containing no apolipoprotein B (non-ApoB) from 1-2 weeks pre-calving to calving. Treatment group calves had higher vitamin E concentrations in serum and non-ApoB than control group calves. Treatment did not affect cholesterol or phospholipid concentrations in serum or the lipoprotein …

    vt Repository record

  15. Apobec-1 Complementation Factor (ACF) Binds and Regulates Multiple RNAs

    Delaney, Kimberly2010

    … through interaction with ARE-Binding Proteins. Apobec-1 Complementation Factor: ACF) was originally identified as a co-factor in ApoB mRNA C to U editing, but has recently been implicated in regulation of mRNA stability as an ARE-Binding Protein. Here we have used tissue culture models with RNA …

    wustl Repository record

  16. Development and application of a novel method to determine large very low density lipoprotein (VLDL1) kinetics

    Alshayji, IqbalUniversity of Glasgow2008

    … due to glucose ingestion on VLDL1-TG and -apoB production rates and Intralipid-TG clearance rate. This showed that hepatic VLDL1 production is suppressed in response to hyperinsulinaemia and that the change in Intralipid-TG clearance rate with hyperinsulinaemia correlated significantly with …

    glasgow Repository record

  17. Transcriptome-Wide Characterization of APOBEC1-Catalyzed RNA Editing Events in Macrophages

    Hamilton, Claire Ellen

    … B mRNA Editing Catalytic polypeptide-1 (APOBEC1). The ADARs and APOBEC1 were originally characterized as catalysts for previously characterized biologically important RNA-editing events that resulted in specific coding changes; study of additional editing activity was limited by standard …

    rockefeller Repository record

  18. Adaptive Immunity in Cardiovascular Disease

    Engelbertsen, DanielDepartment of Clinical Sciences, Lund University2013

    … methylglyoxal-modified apolipoprotein B100 (MGO-ApoB100). In the prospective Malmö Diet and Cancer cohort we studied the relation of T helper 1 (Th1) and T helper 2 (Th2) cells to future cardiovacular events. We found that baseline-levels of Th2 cells, but not Th1 cells, were inversely associated …

    lund Repository record

  19. Immune Responses Aginst Aldehyde Modified Extracellular Matrix in Atherosclerosis

    Dunér, PontusDepartment of Clinical Sciences, Lund University2009

    … including malondialdehyde (MDA) that modifies ApoB in LDL. Immune responses against MDA-modified epitopes on ApoB have been shown to be linked to atherosclerotic disease. This thesis is focused on the possibility that LDL oxidation result in the release of MDA that modified surrounding …

    lund Repository record

  20. Protective Immunity in Atherosclerosis

    Wigren, MariaExperimental Cardiovascular Research Unit, Lund University2011

    … peptides derived from the protein part of LDL, apoB-100, inhibit the development of atherosclerosis. The protective immunity induced by the apoB-100 peptide vaccine aBp210 is associated with an activation of Tregs indicating that specific activation of Tregs could be a promising target in immune …

    lund Repository record

Page 1 of 3