Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Apo(a)"”.
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Roles of human plasma phospholipid transfer protein in high-density lipoprotein metabolism
… reduced the transfer. The increases in apo-A-I or apo-A-II contents of synthetic lipid particle preparations enhanced the transfer, with apo-A-II exerting a greater effect than apo-A-I. However, the apoproteins added to lipoproteins did not yield significant effects. The PL transfer …
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Genetic polymorphism of the human apolipoproteins A and E
… was used to demonstrate the polymorphism of the apolipoproteins E, A-I, A-II and A-IV. Polymorphic forms of apo E were detected after ultracentrifugation of plasma, delipidation of VLDL and isoelectric focusing of the remaining protein. The six common phenotypes, homozygotes E 2/2, E 3/3, E 4/4 …
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Oxidative Modifications of Apolipoprotein(a): Implications for Proinflammatory and Prothrombotic Roles of Lipoprotein(a) in the Vasculature
… levels and risk of cardiovascular disease (CVD). Apo(a) bears striking homology with the zymogen plasminogen and possesses several similar structural features. A key feature shared between these proteins is the presence of multiple repeats of a kringle domain, which possesses the ability to bind …
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Structure and function studies on five homogeneous reconstituted HDL complexes
… cholesterol, cholesterol esters, and apolipoprotein A-I (apo A-I). However, HDL is extremely heterogeneous in size composition and the structure of its lipoprotein components, particularly apo A-I. Due to its inherent structural heterogeneity, structure-function studies on native HDL …
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Apolipoprotein E Activation and Phosphatidylcholine Substrate Requirements of Lecithin Cholesterol Acyl Transferase
The apolipoprotein activation of lecithin cholesterol acyl transferase (LCAT) by human apolipoprotein E (apo E) was investigated by incorporating apo E into discoidal complexes of egg phosphatidylcholine (egg-PC) and cholesterol by the cholate dialysis method. These complexes were systematically …
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The Role of Lipoprotein(a)/Apolipoprotein(a) in Endothelial Dysfunction: Mechanistic Studies in Vascular Endothelium
… (LDL)-like moiety and an unique glycoprotein, apolipoprotein(a) (apo(a)), that is covalently attached to the apolipoproteinB-100 (apoB-100) component of LDL by a single disulfide bond. Many studies have suggested a role for Lp(a) in the process of endothelial dysfunction. Indeed, Lp(a) has been …
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Synthetic Micellar Complexes of Apolipoprotein a-I With Lipids as Substrates for Human Lecithin Cholesterol Acyltransferase
Micellar lipid-apolipoprotein A-I (apo A-I) complexes were produced by adding human apo A-I to lipid dispersions containing sodium cholate. The lipid mixtures included dimyristoyl phosphatidylcholine (DMPC), dipalmitoyl phosphatidylcholine (DPPC), and egg phosphatidylcholine (egg-PC). The formation …
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Studies of G-Protein Coupled Receptors Incorporated Into a Novel, Nanoscale, Membrane-Mimetic System
<p>From first principles of phospholipid — apolipoprotein A-I (apo A-I) interactions, we hypothesized that the amino acid sequence of apo A-I derived from a different species may exhibit improved properties compared to human apo A-I for the purpose of incorporation of G protein-coupled receptors …
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Interaction of Human Apolipoprotein a-I With Dipalmitoyl Phosphatidylcholine
… (DPPC) bilayer lipid will react with human apolipoprotein A-I (apo A-I) to form lipid-protein micellar complexes. The reactivity of the lipid bilayer is dependent upon the physical state of the vesicle. Large vesicles with essentially planar bilayers do not form complexes except at …
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Lipoprotein(a) in vascular health: its role in inflammation, atherosclerosis, and arterial function
… γλυκοπρωτεΐνη που ονομάζεται απολιποπρωτεΐνη(α) [apo(a)] μέσω ενός δισουλφιδικού δεσμού. Ο πυρήνας τύπου LDL περιέχει εστέρες χοληστερόλης, τριγλυκερίδια και απολιποπρωτεΐνη B-100 (apoB-100), ενώ η apo(a) χαρακτηρίζεται από πολλαπλές περιοχές kringle (kringle domains) που παρουσιάζουν υψηλή …
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Lipoprotein(a) and the risk of vascular disease
… particle and a glycoprotein molecule known as apolipoprotein(a) [apo(a)]. Apo(a) exists in several differently-sized isoforms and is responsible for the unique properties of Lp(a). Although Lp(a) has been known for the past 40 years its relationship with coronary heart disease (CHD) has not …
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Estudo da influência da variabilidade em genes de apolipoproteínas sobre níveis lipídicos e parâmetros de massa e gordura corporal na população de Porto Alegre
Apolipoproteínas constituem a parte proteica das lipoproteínas e de uma maneira geral desempenham papéis como proporcionar estabilidade estrutural, solubilizar lipídeos altamente hidrofóbicos, servir como ligantes a receptores ou agir como co-fatores para enzimas envolvidas no metabolismo. Diversos …
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Importancia de la lipoproteína (a) en pacientes con hipercolesterolemia familiar para prevenir el riesgo cardiovascular
… mujeres presentan valores más elevados de HDL y Apo A; valores más bajos en el riesgo CV a los 5 años, a los 10 años y en triglicéridos; y menos frecuencia de infartos. En la comparación entre caso índice y familiar, la única diferencia significativa es que el grupo de caso familiar presenta una …
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Klonierung, Expression und funktionelle Charakterisierung eines Minirezeptors aus der Domäne II des LDL Receptor Related Protein
… Es konnte erstmals gezeigt werden, dass der ApoE-Gehalt von VLDL aus dem Plasma normolipidämischer Personen ausreichend ist, um eine Bindung an die Domäne II des LRP zu vermitteln. Ebenfalls erstmals wurde Lipoprotein(a) als Ligand für die Domäne II des LRP identifiziert, die Ligandenbindung …
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Insight into the carbon cycle from continuous measurements of oxygen and carbon dioxide at Weybourne Atmospheric Observatory, UK
… for the tracer ‘Atmospheric Potential Oxygen’ (APO) are also presented. The analytical methodology is described in detail and the data are examined on interannual, seasonal, synoptic and diurnal timescales. The precision of ambient air measurements is about ±0.03 ppm for CO2 and ±2.0 per meg for …
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Role Of Crebh In Endotoxin Mediated Modulation Of Hepatic Metabolism
… phase response against endotoxemia by modulating apolipoproteins. Endotoxin LPS shock in the body induces activation of the TLR4 signaling pathway in mouse liver. Upon triggering TLR4 signaling pathway, LPS stimulates cleavage and activation of CREBH transcription factor LPS induces the …
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On Bilevel Optimization without Full Unrolls: Methods and Applications
… we introduce Amortized Proximal Optimization (APO), a framework for online meta-optimization of a parametric update rule which governs optimization. APO is based on a 1-step lookahead meta-objective. Under appropriate assumptions, APO can recover existing optimization algorithms such as natural …
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Disruption of Prepulse Inhibition by Apomorphine Across Modalities
… sensorimotor gating. It is well-established that apomorphine (APO), a dopamine agonist, disrupts PPI of the auditory startle response at low prepulse intensities (5-10 dB above baseline noise) at an interstimulus interval (ISI, time between the prepulse and the startle stimulus) of 100msec. In the …
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Veränderungen der Serumlipidwerte bei Alzheimer-Demenz mit Berücksichtigung von APO E-Genotyp und Geschlecht
… noch nicht endgültig aufgeklärt werden, doch ist APO E4 als ein wichtiger genetischer Risikofaktor bekannt. Der E4-Genotyp des APO E-Polymorphismus kodiert das Protein Apo E4, welches insbesondere für den Transport von Lipiden zuständig ist. Zudem ist Apo E4 im Gehirn histologisch mit den …
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Efectos de un programa de ejercicio físico sobre el riesgo cardiovascular y la calidad de vida en la posmenopausia
… HOMA, Colesterol, Triglicéridos, cHDL, cLDL, Apo A, Apo B, creatinina sérica, aclaramiento de creatinina, creatinina en orina, albuminuria y PCR ultrasensible. Resultados: Tras la intervención con un programa estructurado de ejercicio físico de fuerza/resistencia, el peso y el IMC aumentan en …