Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"Aplysia"”.
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Cardioregulatory Role of the Abdominal Ganglion of APLYSIA CALIFORNICA
<p>An isolated heart-abdominal ganglion preparation of this mollusc was developed and used to study the cardioregulatory function of the ganglion and nerves. The heart was perfused with artificial sea water through an atrial cannula and the gastro-esophageal artery was catheterized for blood …
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Analysis of The Distributed Representation of Operant Memory In Aplysia
… underlying an example of operant memory in <em>Aplysia </em>have been previously uncovered. Three studies are described here that sought to draw closer to a thorough characterization of this memory. The first study used a computational model to examine the ways in which sites of plasticity …
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Role of Synapsin In Long-Term Synaptic Facilitation In Aplysia
… technical advantages of the marine mollusc <em>Aplysia </em>were exploited in order to address this issue. In <em>Aplysia</em>, learning-induced enhancement in synaptic strength is modulated by serotonin (5-HT) and treatment with 5-HT in vitro of the sensorimotor synapse induces long-term …
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Modification of Aplysia Feeding Network By L-Dopa and Dopamine-Dependent Learning
… conditioning (OC) of the feeding circuit of <em>Aplysia</em>. OC reduced the excitability of B4 and the B4-to-B51 synaptic connection, with a trend towards an enhancement of the B4-to-B8 synaptic connection. These data indicate that OC can decrease the excitability of neurons and modify synaptic …
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Modelling the synaptic plasticity underlying habituation, sensitization and classical conditioning of the Aplysia Californica Gill Siphon withdrawal reflex
Part I of this thesis aims to familiarize the reader with some of the basics of neuroscience. It includes a simplified description of the functioning of real neurons, as well as an introduction to several of the well known neuron models, including the Hodgkin Huxley equations and the Leaky …
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Analysis of D-Aspartate as a Signaling Molecule in the Aplysia Californica Central Nervous System Using Capillary Electrophoresis and Radioisotopic Labeling
… in the central nervous system. The mollusk Aplysia californica has shown high levels of D-Asp in the neural ganglia; and this, along with its relatively simple invertebrate system, makes Aplysia a viable model system for studying the function and neurochemistry of D-Asp. Using Aplysia …
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Amino acid racemase responsible for the biosynthesis of D-aspartate and D-serine signaling molecules in Aplysia californica central nervous system
… systems (CNS) of some marine mollusks including Aplysia californica, a model animal for cellular and systemic neuroscience study, and D-Asp showed neurotransmitter behaviors in Aplysia CNS, indicating D-Asp signaling pathway is conserved among animal kingdoms. Thus, studying D-Asp in Aplysia can …
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Novel Approaches for the Measurement of Unusual Post-Translational Modifications in Neuropeptides
… a D-amino acid-containing peptide found in Aplysia. These cells are then utilized in the development of a method combining the specificity of an enzyme with liquid chromatography/mass spectrometry to locate novel D-amino acid-containing peptides in the central nervous system of Aplysia …
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Neurotransmitter and Neuromodulator Analysis Using Capillary Electrophoresis With Laser -Induced Fluorescence Detection
… is involved in cell to cell communication in Aplysia californica. In addition, D-Glu is found in the sensory neurons of the sensorimotor synapse and induces a larger cellular response on the motor neurons than L-Asp. A method for single cell analysis of D-amino acid containing peptides in …
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Analysis of enzymatic L/D-peptide isomerization in animals
… of DAACPs in the neurobiological model organism Aplysia californica. Two novel DAACPs were discovered using this method. Based on these results, it was hypothesized that an L/D-peptide isomerase exists in Aplysia which is responsible for the biosynthesis of DAACPs. An assay for isomerase activity …
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Novel Small-RNA Mediated Gene Regulatory Mechanisms for Long-Term Memory
… parallel sequencing to profile the small RNAs of Aplysia. We identified 170 distinct 21-23 nt sized miRNAs, 13 of which were novel and specific to Aplysia. Nine miRNAs were brain-enriched, and several of these were rapidly down-regulated by transient exposure to serotonin, a modulatory …
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The Use of Mass Spectrometry for the Analysis of Biological Samples From Macro- and Microorganisms
… CE sample, the egg layer hormone (ELH) of Aplysia. Various membranes were used as substrates for the analysis in addition to the stainless steel target. An excellent detection limit of 500 fmol was obtained using hydrophobic membranes.
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Characterization and Reversal of Doxorubicin-Mediated Changes In Sensory Neurons
… long-term synaptic facilitation (LTF) in <em>Aplysia</em> sensorimotor co-cultures, a cellular analog of long-term memory formation. In addition, DOX leads to dynamic activation of extracellular signal-regulated kinase (ERK), consisting of an immediate and a delayed phase of activation, and to …
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From Prohormones to Neuropeptides: Mass Spectrometric and Bioinformatic Approaches
… the neuropeptides are predicted with the Aplysia-based algorithms. To verify all predictions, the peptide sequences are confirmed by electrospray quadrupole mass spectrometry (ESI-Q) TOF-MS. Employing information from additional species will help to test our current prediction schemes and …
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Off-Line CE/MALDI MS: Sampling and Deposition Techniques to Incorporate Complementary Analyses for Cellular Assays
… and single cells from the marine mollusc, Aplysia californica , assaying neuronal release, analyzing cone snail venoms, and incorporating radionuclide detection with CE/MALDI MS. The application of the CE/MS technique toward the analysis of these samples shows that this method is capable of …
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Mass spectrometry imaging for probing molecular distributions in the nervous system
… cord from Rattus norvegicus and neurons from Aplysia californica. Mass spectrometry imaging (MSI) is a technique that allows for mass measurement of analytes, while also providing their spatial location and does not require a priori knowledge of the analytes to be imaged. MSI is capable of …
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Mass spectrometry-based investigations to characterize specific cell types within the brain
… this case, single cells from the model organism, Aplysia californica, are isolated for analysis. Mass spectrometry (MS) is well-suited for such applications because it has limits of detection in the attomole range for both small molecule metabolites and peptides, has a wide dynamic concentration …
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Zur Vanadium(V)-katalysierten Oxidation von Bromid und deren Anwendung in der Synthese von Aplysiapyranoid A und strukturell einfacher, bromierter O-Heterocyclen
… als Schlüsselschritte in Totalsynthesen von Aplysiapyranoid A, einem hexasubstituierten, dreifachhalogenierten Tetrahydropyran-abgeleiteten Naturstoff aus Aplysia kurodai, sowie dessen 5-Epimer.
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Neuropeptidomics Across Metazoan Life
… research areas. For example, the sea hare (Aplysia californica) is an excellent model to understand the formation, function and plasticity of neuronal networks, while the honey bee (Apis mellifera) is important for uncovering the mechanisms and evolution of social behavior. As studies in …
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