Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Aplp2"”.
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Funktionelle Charakterisierung der synaptischen Transmission in APP/APLP1/APLP2-defizienten Mäusen
… Transmission haben. Wir untersuchten APP/APLP1/APLP2-Triple-Knockout-Mäuse mittels der patch-clamp-Technik auf Veränderungen der synaptischen Transmission, indem wir hippocampale exzitatorische Neuronen autaptisch kultivierten. Die dreifache Mutation führte zu einer Erhöhung der synaptischen …
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Studies of the cell biological function of the Amyloid Precursor Protein (APP) family in Drosophila melanogaster and mammals
… of APP and its mammalian paralogues, APLP1 and APLP2, were investigated in vivo and in vitro. Using Drosophila melanogaster as a model system, it has been shown that expression of APP, APLP1, or APLP2 in the Drosophila wing leads to cell adhesion defects, which was evident from detached cell …
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Characterization of APPBP2/PAT1a and Analysis of its interaction with APP family Proteins
… Precursor Protein like protein 1 and 2 (APLP1, APLP2), correlate strongly to their subcellular localization. Lines of evidences from Pimplikar and co-workers showed a kinesin light chain (KLC) like protein, termed PAT1 (protein interacting with APP tail 1), interacts with both microtubules and …
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Post-translational processing of proteins implicated in the pathogenesis of Alzheimer's disease.
… Here, the subcellular distributions of APP and APLP2 (amyloid precursor-like protein 2) were demonstrated, by indirect immunocytochemistry, to be overlapping but not the same in both NT2 stem cells and neurones. No obvious differences were apparent when comparing the locations of either APP or …
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The role of extracellular matrix remodelling in brown adipose tissue functions: New candidates
… regulation; 4) I determined the role of Aplp2 and Cyr61, the two most relevant ECM-associated candidates involved in BAT functions regulation, in brown adipocytes functions in vitro using a siRNA- mediated knock-down model. In Chapter 3, we demonstrated that ECMr is required for brown …
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Role of MOA-1, an Anti-phosphatase, and APL-1, an APP-related Protein, in Morphogenesis and Mating Behavior in Caenorhabditis elegans
… Due to the presence of two paralogues, APLP1 and APLP2, which have overlapping functions, the normal function of APP is difficult to elucidate. Knockout of the entire APP gene family in mice results in lethality and developmental defects, indicating that the APP gene family has an essential …
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Expression and Transcriptional Regulation of APL-1, a <i>Caenorhabditis elegans</i> APP Ortholog
… of the APP family which also includes APLP1 and APLP2. In mammals, these proteins share overlapping expression patterns and functions, making experiments difficult to perform and interpret. The nematode <em>Caenorhabditis elegans</em>, however, has only one APP family member: APL-1, an ortholog …