Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"Apicomplexan Parasite"”.
-
Investigation of Specialized Metabolites in Apicomplexan Parasite Life Cycles
… that include various ecological niches are apicomplexan parasites. The most notorious parasites belong to the genera Plasmodium and Toxoplasma, which are responsible for malaria and toxoplasmosis, respectively. Traditional efforts to reduce malaria include pharmaceuticals and prevention of …
-
Lifecycle Progression And The Sexual Development Of The Apicomplexan Parasite Cryptosporidium Parvum
… and a better understanding of the biology of the parasite will help in developing therapeutics against the parasite. Cryptosporidium has a single host lifecycle. Ingested meiotic spores called oocysts release invasive sporozoites in gut. Sporozoites infect intestinal enterocytes where parasites …
-
Molecular detection of the apicomplexan parasite 'X' (APX) in bivalves in New Zealand
… populations has been severely hampered by an apicomplexan parasite called apicomplexan-X (APX) which can act alone, or together with bonamiosis. Despite the commercial significance of this disease, the biology of APX is virtually unknown, with an absence of knowledge of hosts, life cycle and …
-
Investigations of the assembly and function of the Toxoplasma micropore
*Toxoplasma gondii* is an apicomplexan parasite that can invade all warm-blooded animals. One of the characteristic features of this parasite is its pellicle, a complex three-layer membrane that includes flattened vesicles that run the entire parasite. *Toxoplasma*’s pellicle has conferred the …
-
Apicomplexan Class XXVII Myosin - A Computational, Biophysical and Cell Biological Characterisation of PfMyoF in Plasmodium falciparum
The Apicomplexan parasite P. falciparum, a lethal pathogen responsible for half a million deaths per year, relies upon myosin motor proteins for both transmission and virulence. Myosins are ATP-driven mechanoenzymes which either displace or translocate along actin filaments and typically function …
-
Development of an inducible transcriptional control system in plasmodium falciparum with applications to targeted genome editing
… While malaria is caused by multiple distinct parasites of the genus Plasmodium, P. falciparum is responsible for the majority of morbidity and mortality due to the disease. Despite this fact, molecular tools for genetic experimentation in the parasite remain underdeveloped. In particular, the …
-
Characterizing Cystoisospora canis as a Model of Apicomplexan Tissue Cyst Formation and Reactivation
Cystoisospora canis is an Apicomplexan parasite of the small intestine of dogs. C. canis produces monozoic tissue cysts (MZT) that are similar to the polyzoic tissue cysts (PZT) of Toxoplasma gondii, a parasite of medical and veterinary importance, which can reactivate and cause toxoplasmic …
-
The Unconventional Amino Acid Starvation Response of the Malaria Parasite, Plasmodium falciparum
The apicomplexan parasite, Plasmodium falciparum, is the causative agent of the most severe form of malaria, resulting in nearly 1 million deaths each year. The parasite establishes its replicative niche within human erythrocytes, where it degrades massive amounts of host cell hemoglobin, salvaging …
-
Characterisation of the eukaryotic initiation factor 2alpha kinases of Plasmodium falciparum
… protein kinases of the most lethal human malaria parasite, Plasmodium falciparum. As central components of many diverse signalling pathways, protein kinases are crucial for the control of proliferation and differentiation in other eukaryotes; we hypothesise that they play similar roles in P. …
-
Mining the Genetic Diversity of the Pathogenic Protozoan, Neospora caninum
𝘕𝘦𝘰𝘴𝘱𝘰𝘳𝘢 𝘤𝘢𝘯𝘪𝘯𝘶𝘮 is a cyst-forming apicomplexan parasite, responsible for economic and reproductive losses to cattle industries worldwide, and represents a serious neurological disease in canines. Although discovered over three decades ago, progress towards treatment and control strategies against …
-
Genetic diversity in Neospora caninum
The apicomplexan parasite Neospora caninum has been identified as an important cause of disease in the dairy industry because it causes abortion and neonatal mortality in livestock such as cattle, sheep and goats and also causing neuromuscular disorders and death in dogs. Biological diversity …
-
Interrogating Host-Parasite Dynamics During Plasmodium Liver Stage Infection
… global health burden and is caused by the apicomplexan parasite Plasmodium. Plasmodium spp. are transmitted by an Anopheles mosquito and require both host and vector to complete their life cycle. Once in the host, parasites travel to the liver and undergo an obligatory and asymptomatic …
-
Molecular Interactions between Apicomplexan Parasites and their Host Cells
<p>Parasitic diseases caused by pathogens of the Apicomplexan phylum result in hundreds of thousands of deaths per year, in addition to being an immense socioeconomic burden on vulnerable populations. A notorious case is that of Plasmodium parasites, the causative agents of malaria and one of the …
-
Bioinformatics Analysis and Annotation of Microtubule Binding and Associated Proteins (MAPs) - Creating a Database of MAPs
… focused on MAPs in parasitic organisms of the Apicomplexan and Trypanosomatid genera. The protocol for analysis incorporates steps to analyze MAPs from these organisms as well. Malaria (a potentially life threatening disease) is caused by Plasmodium, an Apicomplexan parasite. This parasite is …
-
Using Single-Cell Analyses to Uncover Transcriptional Heterogeneity in Plasmodium falciparum
… worldwide in 2015 alone. It is caused by the apicomplexan parasite Plasmodium, which follows a complex life cycle that consists of multiple stages spanning from the human host to the mosquito vector. Among the Plasmodium parasites causing human malaria, the deadliest species is Plasmodium …
-
Mechanisms underlying neural circuit remodeling in Toxoplasma gondii infection
… barrier and establish a long-term infection. The apicomplexan parasite, Toxoplasma gondii, is one such pathogen with the ability to infect the CNS in virtually all warm-blooded animals, including humans. Across the globe, an estimated 30% of the human population is infected with Toxoplasma, an …
-
Discovery and functional analyses of new components of the apical complex and the pellicle of Toxoplasma gondii
The pellicle of the apicomplexan parasite Toxoplasma gondii is a shared structure among the supergroup Alveolata, which consists of a patchwork of flattened vesicles underneath the plasma membrane. The apical complex, from which the phylum obtains its name, is the defining feature of apicomplexans. …
-
Approaches towards vaccine development against Neospora caninum
Neospora caninum is an apicomplexan parasite that causes neuromuscular paralysis in dogs and abortions in cattle. N. caninum is responsible for losses of several million dollars to the dairy and beef industries in several parts of the world. The key players in the host immune response to N. caninum …
-
Understanding the molecular mechanisms controlling gametogenesis and virulence in Cryptosporidium parvum
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms