Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Apicobasal Polarity"”.
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The Role of Merlin and Apicobasal Polarity In Endometrial Development and Homeostasis
<p>Apicobasal polarity and cell adhesion are necessary for the proper formation and organization of epithelial tissues. Merlin couples cell polarity and adhesion through correct localization of the polarity protein Par3 and maturation of apical junctions. Merlin and Par3 are necessary for the …
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A THREE DIMENSIONAL MODEL OF HUMAN HEPATO-BILIARY ORGANOGENESIS
… biliary morphogenesis process and attained apicobasal polarity in the organoids. The duct morphogenesis process was interrupted by inhibiting Notch signaling, thus creating a liver developmental disease model exhibiting a phenotype similar to Alagille syndrome. Altogether, these results …
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Modeling mammary epithelial cell polarization and the role of podocalyxin in breast tumor progression
… addition of exogenous ECM generated a spatial polarity signal dependent on laminin-1 and α6 and β1 integrins. This caused clusters of mammary epithelial cells to re-localize the junctional complexes to the center of the spheroid prior to lumen formation. In ductal breast carcinoma, a critical …
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A study of the causes and consequences of SFTPC mistrafficking in alveolar type 2 cells using novel organoid models
… defective cellular pathways including altered apicobasal polarity, perturbed lumenogenesis, global endolysosomal dysfunction, and a markedly altered plasma membrane proteome and lipidome. Together, I have forwarded our understanding of SFTPC handling in health, and the pathogenic consequences …
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PRC2 GATEKEEPS THE BALANCE BETWEEN DIRECT AND INDIRECT NEUROGENESIS AND CONTROLS NEURONAL MIGRATION DURING HUMAN CORTICOGENESIS
… to ventricular zone disruption, loss of normal apicobasal polarity, and RGC detachment from the apical surface. Since proper cortical layering depends on RGC detachment from the AJ belt, differentiation and subsequent neuronal migration, we developed a CRISPRa-based system to upregulate AJAP1 in …