Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Apical Constriction"”.
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Rab35 Centered Membrane Trafficking Pathway Directs Apical Constriction During Drosophila Gastrulation
… the prospective mesoderm is driven by the pulsed constriction of apical surfaces. Here, we address the mechanisms by which the irreversibility of pulsed events is achieved while also permitting uniform epithelial behaviors to emerge. We use MSD-based analyses to identify contractile steps and find …
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Molecular organization of the actin cortex in apical constriction and epithelial folding
… nonmuscle contraction by demonstrating that the apical actin cortex and associated proteins are spatially organized in epithelia. In addition, I demonstrate that this spatial organization forms a sarcomere-like actomyosin apparatus, which is essential for epithelial contractility. This updated …
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An analysis of the role of microtubules during tubulogenesis in Drosophila
… embryo, which are formed by coordinated apical constriction and invagination of a polarised epithelial placode, as a model to understand these changes. The role of microtubules (MTs) during morphogenetic processes such as this are not well understood. In order to ascertain their role in …
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Mechanisms of myosin regulation and function during tissue folding
… the ventral side of the embryo constrict their apical sides. Apical constriction drives the formation of a furrow that invaginates, forming a tube, and consequently, a new cell layer in the embryo. Constriction of ventral cells is driven by cycles of assembly and disassembly of actin-myosin …
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A Nuclear Mechanoresponse to Morphogenesis Drives Acquisition of Neuroectoderm Lineage Competence During Pluripotent Cell Differentiation
… pluripotent cells within the embryo undergo an apical constriction and epithelialization morphogenesis in parallel with a cell state transition to prepare for multilineage differentiation. I therefore hypothesized that pluripotency and subsequent cell fate specification involves nuclear …
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The spatial organization of the microtubule cytoskeleton and cell divisions promotes tissue morphogenesis
… such as during collective cell shape changes (apical constriction), is through the attachment of actomyosin networks in each cell to adherens junctions, allowing contractile forces to be integrated across the epithelium. However, how actomyosin connections to junctions are maintained during …
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Zebrafish Posterior Lateral Line Organogenesis Regulation by Notch Signaling
… line system. Notch cell autonomously induces apical constriction and cell adhesion downstream of Fgf signaling and organizes lateral line organs into rosettes independent of patterning cues normally provided by a Wnt/Fgf signaling system. We also show that the ectopic Notch signaling induces …
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Cellular Morphodynamics Reveals Divergent Mechanisms of Gastrulation in Insects
… cellular processes that take place sequentially: apical constriction of tall columnar epithelial cells, cell shortening, mitosis and cell spreading, together contributing to a collective epithelial-mesenchymal transition. In contrast, the application of my pipeline in Tribolium embryos revealed …
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Coordination of cellular force-generation during Drosophila ventral furrow formation
… architecture. This thesis examines how the apical forces generated by Drosophila ventral furrow cells undergoing collective apical constriction are coordinated to fold the tissue. In Chapter 2, I investigate how discrete actomyosin contraction events are coordinated in time and between …
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Imaging Drosophila embryo gastrulation to identify stress fields and biomechanical feedback
… mechanisms of mechanical coordination of the constriction of the cell apices in groups of cells have been proposed. Our previous computational studies have shown a connection between tensile mechanical feedback and Cellular Constriction Chains (CCCs) that propagate during the first phase of …
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Function of Spectrin cytoskeleton in regulating epithelial architecture.
… These cells are highly polarized having distinct apical and basolateral sides; they are tightly connected to each other through cell-cell junctions. Epithelial morphogenesis is important for organogenesis and pivotal for carcinogenesis, although the mechanism is poorly understood. Drosophila FE …