Global ETD Search
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Showing 1 to 6 of 6 for “"Apelin receptor"”.
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The Identification and Pharmacological Characterisation of Novel Apelin Receptor Agonists In Vitro and In Vivo
The apelin system is an evolving transmitter system consisting of the G protein coupled apelin receptor and two endogenous peptide ligands, apelin and elabela. It is implicated as a potential therapeutic for a number of diseases; however, the endogenous peptides are limited by half-life and …
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Investigating the role of the cardiac apelin receptor using human embryonic stem cell derived-cardiomyocytes.
The G-protein coupled apelin receptor and its two endogenous peptide ligands, apelin and Elabela, have emerged as key regulators of cardiovascular development, physiology and disease. It has therefore been suggested that targeting the apelin receptor therapeutically may be beneficial for the …
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Characterisation of the Apelin Receptor and its Endogenous Ligands, Apelin and Elabela/Toddler in the Cardio-Renal System
The apelin system is emerging as an important therapeutic target in several diseases. It comprises a G protein-coupled receptor, the apelin receptor, which binds two peptide ligands, namely apelin and Elabela/Toddler (ELA). Although apelin has been studied in some detail, little is known about the …
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Exploring the therapeutic potential of the apelin receptor signalling axis, and angiotensin-converting enzyme 2 (ACE2) as the SARS-CoV-2 viral entry receptor, in the cardiovascular system
The apelin receptor is a class A GPCR that binds two endogenous peptide ligands, apelin and elabela/Toddler (ELA), to induce positive cardiac inotropy and vasodilatation in the cardiovascular system. The apelin receptor provides a tractable therapeutic target for multiple cardiovascular diseases, …
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Imaging Glioblastoma metabolism using mass spectrometry imaging
… drug sensitivity. One drug, MM315, an apelin receptor antagonist that is known to play a role in angiogenesis and differentiation of neural progenitor cells, significantly prolonged the survival of orthotopically implanted patient-derived xenografts and led to apoptosis of primary GB …
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Elucidating the Role of Two Inotropic Agents in Cardiac Hypertrophy: the Ceramides and Apelins
… of CVD. The inotropic agents, the ceramides and apelins, represent two potential druggable targets that influence cardiovascular function. In this dissertation, we examined the impact of silencing the ceramide synthases (CERS) responsible for the production of the putative protective very …