Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Apelin"”.
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Characterisation of the Apelin Receptor and its Endogenous Ligands, Apelin and Elabela/Toddler in the Cardio-Renal System
The apelin system is emerging as an important therapeutic target in several diseases. It comprises a G protein-coupled receptor, the apelin receptor, which binds two peptide ligands, namely apelin and Elabela/Toddler (ELA). Although apelin has been studied in some detail, little is known about the …
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The Identification and Pharmacological Characterisation of Novel Apelin Receptor Agonists In Vitro and In Vivo
The apelin system is an evolving transmitter system consisting of the G protein coupled apelin receptor and two endogenous peptide ligands, apelin and elabela. It is implicated as a potential therapeutic for a number of diseases; however, the endogenous peptides are limited by half-life and …
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Investigating the role of the cardiac apelin receptor using human embryonic stem cell derived-cardiomyocytes.
The G-protein coupled apelin receptor and its two endogenous peptide ligands, apelin and Elabela, have emerged as key regulators of cardiovascular development, physiology and disease. It has therefore been suggested that targeting the apelin receptor therapeutically may be beneficial for the …
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Evaluation of metabolic and cardiovascular actions of [Pyr1]apelin-13 in patients with Type 2 diabetes mellitus
… of metabolic and cardiovascular actions of [Pyr1]apelin-13 in patients with Type 2 diabetes mellitus Type 2 diabetes mellitus (T2DM) is common, long term metabolic disorder characterised by hyperglycaemia (high blood glucose) resulting from insulin resistance (IR) and insulin insufficiency. Type 2 …
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Exploring the therapeutic potential of the apelin receptor signalling axis, and angiotensin-converting enzyme 2 (ACE2) as the SARS-CoV-2 viral entry receptor, in the cardiovascular system
The apelin receptor is a class A GPCR that binds two endogenous peptide ligands, apelin and elabela/Toddler (ELA), to induce positive cardiac inotropy and vasodilatation in the cardiovascular system. The apelin receptor provides a tractable therapeutic target for multiple cardiovascular diseases, …
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Stimulation de la régénération endogène dans le traitement de la dystrophie musculaire
… maintain muscle function. We describe the use of Apelin-13 as a potential candidate for the treatment of muscular dystrophy. Apelin is an endogenous peptide that has been studied for many years in relation to its beneficial effect on the cardiovascular system and its anti-diabetic effects in mice. …
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Elucidating the Role of Two Inotropic Agents in Cardiac Hypertrophy: the Ceramides and Apelins
… of CVD. The inotropic agents, the ceramides and apelins, represent two potential druggable targets that influence cardiovascular function. In this dissertation, we examined the impact of silencing the ceramide synthases (CERS) responsible for the production of the putative protective very …
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Examination of ex-vivo lung perfusion in porcine model
… injury model, based on the initial DCD model. Apelin is a vasoactive peptide, with previously described roles in angiogenes.is and vasodilatation through the eNOS pathway. I have investigated the modulatory effects of Apelin in the model of one lung injured by warm ischaemia. While this model …
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Imaging Glioblastoma metabolism using mass spectrometry imaging
… drug sensitivity. One drug, MM315, an apelin receptor antagonist that is known to play a role in angiogenesis and differentiation of neural progenitor cells, significantly prolonged the survival of orthotopically implanted patient-derived xenografts and led to apoptosis of primary GB …
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Genome-wide census and expression profiling of chicken neuropeptide and prohormone convertase genes
… multiple conditions. Five neuropeptide genes (apelin, cocaine- and amphetamine-regulated transcript protein, insulin-like 5, neuropeptide S, and neuropeptide B) previously unknown in chicken were identified and 62 genes were confirmed. Although most neuropeptide gene families known in the human …
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Pathophysiological role of aldosterone in cardiac remodelling after myocardial infarction
… that circulating concentrations of the peptide apelin were reduced over 24 weeks after AMI compared to healthy controls but bore no relationship to LV function. Separately, I showed that concentrations of the soluble interleukin-1 receptor family member ST2 fell significantly over time after AMI …