Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Apamin"”.
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Effect of dopamine on synchronous neuronal oscillations in the globus pallidus-subthalamic nucleus network
… combination with the potassium channel blocker apamin (50 -100 nM). The burst activity was unaffected by bath application of picrotoxin or CNQX while paired STN recordings showed uncorrelated activity indicating that the activity is not produced by the neuronal network. Thus, no regenerative …
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Detection of SK2 Channels on Hippocampal Neurons
… between cell surface expressed SK channels and apamin, a toxin that specifically binds to SK channels, it was found that SK channels are spatially organized in nanodomains of one to three channels. It is also shown that SK channel distribution in pyramidal neurons is polarized, increasing by 40 …
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PIP2 Modulation of Afterhyperpolarizations in Magnocellular Supraoptic Neurons
… channels, a medium component (mAHP) underlain by apamin-sensitive SK channels, and a slow component (sAHP) which is an apamin-insensitive K+ conductance. The mechanisms that control the sAHP are poorly understood in MNCs. The work embodied here explores the mechanisms involved in generation of …
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Wirkung des Benzodiazepins Midazolam auf die Dünndarmperistaltik des Meerschweinchens in vitro
… Austausch der Tyrode-Lösung aufgehoben werden. Apamin (500 nM) und Naloxon (500 nM) antagonisierten die inhibitorischen Effekte des Midazolams auf die Peristaltik. Zusammenfassung: Unsere Ergebnisse zeigen, dass das kurzwirksame Benzodiazepin Midazolam die Dünndarmperistaltik dosisabhängig in …
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Vascular action of glycine in hypertensive rat models
… intermediate conductance K+ channel inhibitors, apamin and Tram-34/charybdotoxin. In contrast, intravenous administration of glycine evoked a fall in BP in normotensive Wistar-Kyoto (WKY) rats and an elevation of BP in spontaneously hypertensive rats (SHR), and in WKY rats subjected to chronic …
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Relaxin: a new cardiovascular hormone in humans? Comparative potency and mechanisms of action
… oxide synthase (NOS) inhibitors and EDHF with apamin and charybdotoxin (potassium channel blockers) (n=7) had a curious effect causing the opposite action to that expected, by enhancing relaxin’s vasodilatory action. In patients not treated with an ACE inhibitor, we found that manipulation of …
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Calcium and growth hormone secretion in the domestic fowl (Gallus domesticus)
… the maximal depolarisation that was reached, apamin removed the ability of the cells to repolarisc and thus depolarisation was prolonged. In the presence of these agents an enhanced release of growth hormone was observed under conditions of a prolonged depolarisation whilst it was diminished …
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Pharmacologically impeding glioblastoma tumour motility through simultaneous inhibition of aquaporin-1 and ion channels
… Ion channel blockers nifedipine, amiloride, apamin, 4-aminopyridine, and AMPA/kainate receptor inhibitor cyanquixaline significantly decreased invasion in U87-MG and U251-MG, effects that were additively enhanced upon co-treatment with AqB013. Interestingly, when solid tumour spheroids of …
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Simulating the Affects of Glutamatergic Afferents on the Firing Pattern of Midbrain Dopamine Neurons
A computational model of a midbrain dopamine neuron was extended in this study to include a response to random excitatory afferent input by incorporating the receptor components AMPA and NMDA. In a diagonal band where average glutamatergic and tonic gabaergic input is roughly balanced, both single …