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Showing 1 to 3 of 3 for “"Ap4A"”.
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Establishing DNA combing to investigate DNA replication stress in vitro
… DNA replication. Next the inhibitory effect of Ap4A in cell free DNA replication assays is studied. These data suggest that Ap4A inhibits initiation by reducing loading of the replicative helicase MCM2-7 and the DNA polymerase sliding clamp PCNA. These data suggest that Ap4A can inhibit the …
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Wechselwirkungen zwischen Replikationsproteinen und Origin-DNA während Proliferation und terminaler Differenzierung
… erfolgt und dass Diadenosin-Tetraphosphat (Ap4A) die Bindung von preRC-Proteinen an die DNA nicht signifikant stimuliert. Zur Eingrenzung der preRC-Bindungsstelle wurden sowohl am 5´- als auch am 3´-Ende partiell deletierte B-Fragmente eingesetzt. Mit den um 100 bp verkürzten Fragmenten kann …
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Mechanisms of polyphosphate degradation
The goal of my research has been to investigate the mechanisms by which inorganic polyphosphate (polyP) is degraded in vivo. PolyP is a linear chain of phosphate moieties linked through high-energy phosphoanhydride bonds and can range in size from three-phosphates-long to thousands. Naturally, …