Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Aortopathy"”.
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Identifying Regional DNA Methylation Patterns in the Human Aorta in Health and Disease
… with progressive dilation of the aorta (aortopathy) which can lead to sudden and life-threatening complications including dissection and rupture. Diagnosis of asymptomatic BAV-associated aortopathy is challenging and, once identified, criteria for surgical intervention are poorly defined. …
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Imaging microcalcium in thoracic aortic disease
… [1.00 to 2.16], p=0.05). Microcalcification in aortopathy: histology study Thoracic aortopathies are associated with microcalcification which has the potential to be visualised non-invasively using 18F-sodium fluoride positron emission tomography. Thoracic aortic samples were collected from 75 …
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Novel molecular imaging of cardiovascular disease in man
… highly inflamed, suggesting presence of a global aortopathy rather than a disease confined only to the abdominal region of the aorta. Aortic aneurysms have greater active inflammation and calcification than atherosclerotic controls suggesting a more intense, destructive and transmural pathological …
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Deconvoluting genetic variants associated with aortic disease using stem cell models
… Tier One variants, protein truncating in known aortopathy-related genes. Variants in lysyl oxidase (LOX, 122070160 T>TA), myosin light chain kinase (MYLK, 123401069 ACT>A) and mothers against decapentaplegic homolog 4 (SMAD4, 51076665 C>T) were selected. CRISPR-Cas9 genetic editing introduced …
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Large Artery Stiffness: Genes and Pathways
… TGFβ signalling in this emerging familial aortopathy and underscored the significance of TGFβ signalling in aortic extracellular matrix biology. The second part of this work attempted to characterise the biological basis for the susceptibility lo- cus identified in the most recent genome …
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Investigating Medical Examiners' Practices: Genetic Evaluation For Fatal Acute Aortic Dissection
<p>Acute thoracic aortic dissection (TAD) is a life-threatening event with a hereditary component. Currently, pathogenic variants in 11 genes associated with aortic aneurysm and dissection predispose to a heritable form of disease thereby conferring an increased risk for TAD. Genetic testing plays …