Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"Aortic aneurysm"”.
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Outcomes of ruptured abdominal aortic aneurysm
Ruptured abdominal aortic aneurysm (RAAA) is a life-threatening event, and without operative treatment the patient will die. The overall mortality can be as high as 80-90%; thus repair of RAAA should be attempted whenever feasible. The quality of life (QoL) has become an increasingly important …
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Risk Factors in Abdominal Aortic Aneurysm
The mortality rate of ruptured abdominal aortic aneurysm (AAA) has been reported to be as high as 85%. Evidence suggests that ultrasound screening reduces overall and AAA-related mortality. The aim of this study was to identify and document risk factors for AAA from the largest Welsh cohort …
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Molecular genetics of abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) is a common disorder and a major cause of death. Pathological processes involved in AAA formation include inflammation, proteolysis, angiogenesis and apoptosis. It has also a strong familial predisposition with linkage studies identifying chromosomes 19q13 and 4q31 …
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Abdominal Aortic Aneurysm – Different Aspects on Screening
Abstract Abdominal aortic aneurysm (AAA) is a hideous life threatening disease that most often is asymptomatic until it ruptures. Ruptured abdominal aortic aneurysm (rAAA) is a painful and serious predicament with a mortality of 80-90%. Half of the patients die before arriving to hospital, leaving …
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Prediction of outcome after abdominal aortic aneurysm rupture
… for outcome prediction after abdominal aortic aneurysm (AAA) rupture and to design and validate a novel risk scoring instrument. It also aims to examine the utility of novel predictive variables. Finally, it examines the functional outcomes achieved by survivors of aneurysm rupture.
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Osteoprotegerin: a pathological role in human abdominal aortic aneurysm
Rupture of Abdominal Aortic Aneurysm (AAA) is the end-stage, catastrophic failure of the aneurysmal aortic wall and is associated with a mortality rate of up to 95 percent. Presently, surgery is the only treatment option available but carries with it a mortality rate of up to five percent and is …
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Novel strategies to increase Sirtuin-1 activity in aortic aneurysm
… and anti-oxidant effects on the aortic wall are involved in preventing vascular diseases, such as aortic aneurysm (AA) and dissection. We demonstrated that SirT1 in vascular smooth muscle (VSM), the major component of large arteries, is indispensable in maintaining vascular wall …
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Total Plasma Homocysteine, Vitamins, Abdominal Aortic Aneurysm and Peripheral Vascular Disease
… relationship between homocysteine and abdominal aortic aneurysm (AAA), peripheral vascular disease (PVD), and the effect of vitamin B<sub>12</sub> and folic acid blood levels on plasma homocysteine concentration. This study was aimed to examine this possible …
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Mechanical Effects of Surgical Adhesives on Ascending Thoracic Aortic Aneurysm Replacement
<p>Ascending thoracic aortic aneurysm (aTAA) is a potentially lethal disease which grows gradually over time and may lead to aortic dissection and rupture. Currently, aTAA surgical repair using Dacron graft is a well-established treatment. In addition, surgical adhesives are frequently used in the …
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Role of vascular smooth muscle Interleukin-11 in aortic aneurysm development
BACKGROUND: The formation of aortic aneurysms (AAs) presents a significant cardiovascular risk, with limited treatment options. Our laboratory examined wild-type (WT) and BCL11B knockout (BSMKO) mice treated with Angiotensin II (AngII) for a period of 7 days. The BSMKO mice given AngII exhibited …
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Predicting the risk of progression in patients with thoracic aortic aneurysm
… biomarkers in a cohort of 50 patients with aneurysms of the arch and descending thoracic aorta. I have described within this thesis various obstacles (logistical and biological) to identifying biomarkers of aneurysm progression. Despite these challenges, I have created a unique dataset …
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Imaging of abdominal aortic aneurysm disease activity and implications for endovascular aneurysm repair
BACKGROUND: Abdominal aortic aneurysm treatment pathways are initiated when an aortic size threshold of 55 mm is reached as this signifies a high annual risk of rupture due to presumed active aneurysm disease. Endovascular aneurysm repair (EVAR) is one treatment modality which reduces the …
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Identification of in vivo material properties of ascending thoracic aortic aneurysm: towards noninvasive risk assessment
… risk assessment of ascending thoracic aortic aneurysm (ATAA). A novel inverse method was developed for in vivo hyperleastic property identification from clinical 3D CT image data. The developed inverse approach was validated by using numerical examples as well as clinical CT images and …
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Fluid Flow Characterization and In Silico Validation in a Rapid Prototyped Abdominal Aortic Aneurysm Model
<p>Aortic aneurysms are the 14<sup>th</sup> leading cause of death in the United States. Annually, abdominal aortic aneurysm (AAA) ruptures are responsible for 4500 deaths. There are another 45,000 repair procedures performed to prevent rupture, and of these approximately 1400 lead to deaths. With …
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The results of surgical treatment of abdominal aortic aneurysm: influence and evaluation of comorbidities, demographic and surgical risk factors /
… results of non-ruptured and ruptured abdominal aortic aneurysm. In the introduction the aim of the study and objectives are listed. In the review of the literature main problems of pending topic are analyzed. The methodology is described in a special chapter. The results of 373 patients’ …
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A retrospective audit into the morbidity and mortality of open abdominal aortic aneurysm repair at Groote Schuur Hospital, Cape Town
… is 4-8%. Many patients presenting with abdominal aortic aneurysms are elderly and have pre-existing medical conditions, therefore putting them at high risk for numerous post-operative complications, such as acute kidney injury, pulmonary and cardiac complications. These complications lead to …
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Obstructive Sleep Apnea Risk in Abdominal Aortic Aneurysm Disease Patients: Associations with Physical Activity Status, Metabolic Syndrome, and Exercise Tolerance
… highly prevalent among patients with abdominal aortic aneurysm (AAA) disease. Objectives: Examine associations between OSA risk and physical activity (PA), metabolic syndrome (MetSyn), and exercise responses to cardiopulmonary exercise testing (CPET) in elderly patients with AAA disease. …
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A Markov decision analysis model to aid the vascular surgeon in the management of a patient with an asymptomatic infra-renal abdominal aortic aneurysm
… of endovascular (EVAR) and open abdominal aortic aneurysm repair, it is often unclear which technique is most appropriate for an individual patient. We have designed a decision analysis model that will predict survival, reintervention rates and other parameters for individual patients. …
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