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Showing 1 to 10 of 10 for “"Aortic Heart Valve"”.
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Non-linear finite element analyses of the aortic heart valve
Finite element models of the aortic heart valve have been successfully used in the past to gain insight into the mechanics of the valve and to aid in understanding of valve failure. Moreover such models are indispensable tools for further developments in heart valve prosthetic design. In previous …
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Multiscale simulations of the aortic heart valve : applications in disease and surgery
… describing the mechanical behavior of the human aortic heart valve over a range of length and time scales. In the human heart, the valves perform the vital function of controlling the direction of blood flow. Each valve is an intricate mechanical structure, with distinct features and functions at …
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Treatment of Aortic Heart Valve Conduit with Glutamine and Heat Shock as a Means to Deter the Constituent Cellular Population From Becoming Apoptotic
<p>Cryopreserved allograft heart valves represent the best solution for a patient with a failing heart valve. However, the constituent cells become apoptotic and within months of transplant the heart valve becomes acellular and the recipient's cells do not repopulate the allograft (3, 51). A …
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Development of methods for the tissue engineering of cardiac valves using mesenchymal stem cells
Cardiac valve replacement is the second most common heart operation in the Western World. Valve replacements currently available are poorly adapted for use in young patients who typically require multiple re-operations as they grow, resulting in increased morbidity and mortality. Tissue-engineering …
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Predicting Transcatheter Aortic Valve Leaflet Thrombosis Risk Using Pre-Procedural Computed Tomography Angiogram and Computational Modeling
Aortic stenosis (AS) is a disease that affects nearly 3% of adults above the age of 65 and is characterized by narrowing of the aortic heart valve due to calcium buildup. It restricts blood flow from the heart and, if left untreated, can lead to irreversible damage to the left ventricle wall and …
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Fluid Flow Characterization and In Silico Validation in a Rapid Prototyped Aortic Arch Model
<p>Transcatheter aortic heart valve replacement (TAVR) is a procedure to replace a failing aortic valve and is becoming the new standard of care for patients that are not candidates for open-heart surgery [2]. However, this minimally invasive technique has shown to cause ischemic brain lesions, or …
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NOVEL NANOFIBER-BASED GRAFT FOR HEART VALVE REPLACEMENT
Creating a functional heart valve graft that lasts a lifetime is one of the main targets of cardiovascular tissue engineering. While processed conventional collagen-based heart valves have been used for many years, they eventually fail because of inadequate cell infiltration and insufficient …
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A novel polymeric prosthetic heart valve: design, manufacture, and testing
… thesis a flexible leaflet polymeric prosthetic aortic heart valve was designed, manufactured, and tested. The prosthesis was designed with the aim of overcoming the need for anticoagulant therapy, which is required for current mechanical prostheses; while also having lifelong durability, which …